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- gmt064 author "Bishayee K, Khuda-Bukhsh AR".
- gmt064 date "Sep 2013".
- gmt064 date "September 2013".
- gmt064 doi "10.1093/abbs/gmt064".
- gmt064 first1 "K".
- gmt064 first2 "AR".
- gmt064 isCitedBy Antileukotriene.
- gmt064 isCitedBy Arachidonate_5-lipoxygenase.
- gmt064 isCitedBy Arachidonate_5-lipoxygenase_inhibitor.
- gmt064 isCitedBy Curcumin.
- gmt064 isCitedBy Prostate_cancer.
- gmt064 issue "9".
- gmt064 journal "Acta Biochim. Biophys. Sin.".
- gmt064 journal "Acta Biochimica et Biophysica Sinica".
- gmt064 last1 "Bishayee".
- gmt064 last2 "Khuda-Bukhsh".
- gmt064 pages "709–19".
- gmt064 pages "709–719".
- gmt064 pmid "23752617".
- gmt064 quote "Recent studies demonstrated the involvement of growth factors, such as epidermal growth factor and neurotensin in the 5-LOX-mediated tumor progression in prostate cancer [22,23]. Recent studies with 5-LOX siRNA [10] and specific blocker of 5-LOX [24] revealed the relation of this gene with the tumor cell proliferation. ... Meclofenamate sodium is known for its anti-inflammatory activity, and apart from this, Boctor et al. [37] reported that it caused reduction in the formation of 5-HETE in human leucocytes when used. MS can thus be considered a dual inhibitor of 5-LOX and COX pathways of arachidonic acid cascade. Further investigation with this substance revealed that it could interfere with the LT receptors in the lung carcinoma [38]. In a recent study, a group of scientists have shown the effect of MS on prostate cancer cells both in vitro and in vivo [39], and their result suggests a profound reduction in the tumor growth and cancer metastasis. ... While the commonly used inhibitors produced strong cytotoxicity, notably, zileuton, the only commercialized 5-LOX inhibitor, failed to induce an anti-proliferative or cytotoxic response in all other types of tumor cells where 5-LOX was in inactive state ; however, where 5-LOX was in active state, zileuton could effectively inhibit progression, as in case of prostate cancer.".
- gmt064 title "5-lipoxygenase antagonist therapy: a new approach towards targeted cancer chemotherapy".
- gmt064 url 709.long.
- gmt064 vauthors "Bishayee K, Khuda-Bukhsh AR".
- gmt064 volume "45".