Matches in DBpedia 2016-04 for { <http://doi.org/10.1038/nature16932> ?p ?o }
Showing triples 1 to 9 of
9
with 100 triples per page.
- nature16932 accessdate "2016-02-06".
- nature16932 doi "10.1038/nature16932".
- nature16932 isCitedBy Senolytic.
- nature16932 journal "Nature".
- nature16932 pmid "26840489".
- nature16932 quote "(To explore the physiological relevance and consequences of naturally occurring senescent cells, here we use a previously established transgene, INK-ATTAC, to induce apoptosis in p16Ink4a-expressing cells of wild-type mice by injection of AP20187 twice a week starting at one year of age. We show that compared to vehicle alone, AP20187 treatment extended median lifespan in both male and female mice of two distinct genetic backgrounds. The clearance of p16Ink4a-positive cells delayed tumorigenesis and attenuated age-related deterioration of several organs without apparent side effects, including kidney, heart and fat, where clearance preserved the functionality of glomeruli, cardio-protective KATP channels and adipocytes, respectively.)".
- nature16932 title "Naturally occurring p16-positive cells shorten healthy lifespan".
- nature16932 vauthors "Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, A Saltness R, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM".
- nature16932 year "2016".