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- dneu.20778 doi "10.1002/dneu.20778".
- dneu.20778 isCitedBy Neurobiological_effects_of_physical_exercise.
- dneu.20778 issue "5".
- dneu.20778 journal "Dev Neurobiol".
- dneu.20778 pages "384–96".
- dneu.20778 pmid "20186710".
- dneu.20778 quote "However, the adult brain appears to have an external input from serum IGF-I, where this anabolic peptide is abundant. Thus, serum IGF-I has been proven to be an important modulator of brain activity, including higher functions such as cognition. Many of these functions can be ascribed to its tissue-remodeling activity as IGF-I modulates adult neurogenesis and angiogenesis. Other activities are cytoprotective; indeed, IGF-I can be considered a key neuroprotective peptide. Still others pertain to the functional characteristics of brain cells, such as cell excitability. Through modulation of membrane channels and neurotransmission, IGF-I impinges directly on neuronal plasticity, the cellular substrate of cognition. However, to fully understand the role of IGF-I in the brain, we have to sum the actions of locally produced IGF-I to those of serum IGF-I ... An operational approach to overcome this limitation would be to consider IGF-I as a signal coupling environmental influences on body metabolism with brain function. Or in a more colloquial way, we may say that IGF-I links body "fitness" with brain fitness".
- dneu.20778 title "Toward a comprehensive neurobiology of IGF-I".
- dneu.20778 vauthors "Torres-Aleman I".
- dneu.20778 volume "70".
- dneu.20778 year "2010".