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- Zonulin abstract "Zonulin syn. Haptoglobin (http://www.uniprot.org/uniprot/P00738) is a protein that modulates the permeability of tight junctions between cells of the wall of the digestive tract. It was discovered in 2000 by Alessio Fasano and his team at the University of Maryland School of Medicine. As the mammalian analogue of zonula occludens toxin, secreted by cholera pathogen Vibrio cholerae, zonulin has been implicated in the pathogenesis of coeliac disease and diabetes mellitus type 1.Gliadin (glycoprotein present in wheat) activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules.Zonula occludens toxin is being studied as an adjuvant to improve absorption of drugs and vaccines. In 2014 a zonulin receptor antagonist, Larazotide acetate (formerly known as AT-1001), completed a phase 2b clinical trial.Giovanni Barbara and a team of researchers at the University of Bologna measured blood levels of zonulin in four groups of individuals: those with Celiac Disease, those with irritable bowel syndrome marked by diarrhea, those with self-diagnosed gluten sensitivity and healthy volunteers. Both celiacs and gluten-sensitives turned up with remarkably high levels of zonulin in their blood. Those with IBS had elevated levels but less than half the levels of celiacs or gluten-sensitive individuals. Healthy volunteers had negligible blood levels of zonulin. The results were presented in October as an abstract at the 23rd United European Gastroenterology Week in Barcelona, Spain. \"I was very surprised, but not only by the zonulin levels,\" says Barbara. \"In our study, gluten-sensitive individuals who responded to a gluten-free diet had a genetic predisposition to celiac disease. They had no evidence of celiac, but they did have the vulnerable genes that put a person at risk of celiac.\"".
- Zonulin wikiPageExternalLink P00738).
- Zonulin wikiPageID "9905521".
- Zonulin wikiPageLength "3559".
- Zonulin wikiPageOutDegree "17".
- Zonulin wikiPageRevisionID "705756607".
- Zonulin wikiPageWikiLink Alessio_Fasano.
- Zonulin wikiPageWikiLink Category:Digestive_system.
- Zonulin wikiPageWikiLink Cell_(biology).
- Zonulin wikiPageWikiLink Cholera.
- Zonulin wikiPageWikiLink Coeliac_disease.
- Zonulin wikiPageWikiLink Diabetes_mellitus_type_1.
- Zonulin wikiPageWikiLink Gastrointestinal_tract.
- Zonulin wikiPageWikiLink Gliadin.
- Zonulin wikiPageWikiLink Intestinal_permeability.
- Zonulin wikiPageWikiLink Protein.
- Zonulin wikiPageWikiLink Receptor_antagonist.
- Zonulin wikiPageWikiLink Tight_junction.
- Zonulin wikiPageWikiLink University_of_Bologna.
- Zonulin wikiPageWikiLink University_of_Maryland,_Baltimore.
- Zonulin wikiPageWikiLink Vibrio_cholerae.
- Zonulin wikiPageWikiLink Zonula_occludens_toxin.
- Zonulin wikiPageWikiLinkText "Zonulin".
- Zonulin wikiPageWikiLinkText "zonulin".
- Zonulin wikiPageUsesTemplate Template:Protein-stub.
- Zonulin subject Category:Digestive_system.
- Zonulin comment "Zonulin syn. Haptoglobin (http://www.uniprot.org/uniprot/P00738) is a protein that modulates the permeability of tight junctions between cells of the wall of the digestive tract. It was discovered in 2000 by Alessio Fasano and his team at the University of Maryland School of Medicine.".
- Zonulin label "Zonulin".
- Zonulin sameAs Q8074021.
- Zonulin sameAs Zonulina.
- Zonulin sameAs m.02pwl2v.
- Zonulin sameAs Q8074021.
- Zonulin wasDerivedFrom Zonulin?oldid=705756607.
- Zonulin isPrimaryTopicOf Zonulin.