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Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/X-linked_agammaglobulinemia> ?p ?o }

• X-linked_agammaglobulinemia abstract "X-linked agammaglobulinemia (also called X-linked hypogammaglobulinemia, XLA, Bruton type agammaglobulinemia, Bruton syndrome, or Sex-linked agammaglobulinemia) is a rare X-linked genetic disorder discovered in 1952 that affects the body's ability to fight infection. XLA is an X-linked disorder, and therefore is much more common in males. XLA patients do not generate mature B cells, which manifests as a complete lack of antibodies in their bloodstream. B cells are part of the immune system and normally manufacture antibodies (called immunoglobulins), which defend the body from infections by sustaining an immunological humoral antibody response. Patients with untreated XLA are prone to develop serious and even fatal infections. A mutation occurs at the Bruton's tyrosine kinase (Btk) gene that leads to a severe block in B cell development (at the pro-B to pre-B cell stage) and a reduced Immunoglobulin (antibody) production in the serum. Btk is particularly responsible for mediating B cell development and maturation through a signaling effect on the B cell receptor BCR. Patients typically present in early childhood with recurrent infections, in particular with extracellular, encapsulated bacteria. It occurs in a frequency of about 1 in 100,000 male newborns, and has no ethnic predisposition. XLA is treated by infusion of human antibody. Treatment with pooled gamma globulin cannot restore a functional population of B cells, but it is sufficient to reduce the severity and number of infections due to the passive immunity granted by the exogenous antibodies.XLA is caused by a mutation on the X chromosome of a single gene identified in 1993 which produces an enzyme known as Bruton's tyrosine kinase, or Btk. XLA was first characterized by Dr. Ogden Bruton in a ground-breaking research paper published in 1952 describing a boy unable to develop immunities to common childhood diseases and infections. It is the first known immune deficiency, and is classified with other inherited (genetic) defects of the immune system, known as primary immunodeficiency disorders.".
• X-linked_agammaglobulinemia icd10 "D80.0".
• X-linked_agammaglobulinemia icd9 "279.04".
• X-linked_agammaglobulinemia omim "300300".
• X-linked_agammaglobulinemia thumbnail X-linked_recessive.svg?width=300.
• X-linked_agammaglobulinemia wikiPageExternalLink BTKbase.
• X-linked_agammaglobulinemia wikiPageExternalLink brutons.
• X-linked_agammaglobulinemia wikiPageExternalLink x-linked_agammaglobulinemia.jsp.
• X-linked_agammaglobulinemia wikiPageExternalLink www.ipopi.org.
• X-linked_agammaglobulinemia wikiPageExternalLink br.fcgi?book=gene&part=xla.
• X-linked_agammaglobulinemia wikiPageExternalLink www.primaryimmune.org.
• X-linked_agammaglobulinemia wikiPageID "2507689".
• X-linked_agammaglobulinemia wikiPageLength "12098".
• X-linked_agammaglobulinemia wikiPageOutDegree "87".
• X-linked_agammaglobulinemia wikiPageRevisionID "708133411".
• X-linked_agammaglobulinemia wikiPageWikiLink Allergy.
• X-linked_agammaglobulinemia wikiPageWikiLink Antibiotics.
• X-linked_agammaglobulinemia wikiPageWikiLink Antibody.
• X-linked_agammaglobulinemia wikiPageWikiLink Antigen.
• X-linked_agammaglobulinemia wikiPageWikiLink Autoimmunity.
• X-linked_agammaglobulinemia wikiPageWikiLink B-cell_receptor.
• X-linked_agammaglobulinemia wikiPageWikiLink B_cell.
• X-linked_agammaglobulinemia wikiPageWikiLink Bacteria.
• X-linked_agammaglobulinemia wikiPageWikiLink Blood.
• X-linked_agammaglobulinemia wikiPageWikiLink Bone_marrow.
• X-linked_agammaglobulinemia wikiPageWikiLink Brutons_tyrosine_kinase.
• X-linked_agammaglobulinemia wikiPageWikiLink CD19.
• X-linked_agammaglobulinemia wikiPageWikiLink CD20.
• X-linked_agammaglobulinemia wikiPageWikiLink Category:Neurocutaneous_conditions.
• X-linked_agammaglobulinemia wikiPageWikiLink Category:Predominantly_antibody_deficiencies.
• X-linked_agammaglobulinemia wikiPageWikiLink Category:X-linked_recessive_disorders.
• X-linked_agammaglobulinemia wikiPageWikiLink Central_nervous_system.
• X-linked_agammaglobulinemia wikiPageWikiLink Common_variable_immunodeficiency.
• X-linked_agammaglobulinemia wikiPageWikiLink Coxsackievirus.
• X-linked_agammaglobulinemia wikiPageWikiLink Echovirus.
• X-linked_agammaglobulinemia wikiPageWikiLink Encephalitis.
• X-linked_agammaglobulinemia wikiPageWikiLink Enterovirus.
• X-linked_agammaglobulinemia wikiPageWikiLink Epstein–Barr_virus.
• X-linked_agammaglobulinemia wikiPageWikiLink Fetus.
• X-linked_agammaglobulinemia wikiPageWikiLink Food_and_Drug_Administration.
• X-linked_agammaglobulinemia wikiPageWikiLink Gamma_globulin.
• X-linked_agammaglobulinemia wikiPageWikiLink Gene.
• X-linked_agammaglobulinemia wikiPageWikiLink Gene_therapy.
• X-linked_agammaglobulinemia wikiPageWikiLink Genetic_carrier.
• X-linked_agammaglobulinemia wikiPageWikiLink Genetic_predisposition.
• X-linked_agammaglobulinemia wikiPageWikiLink HIV.
• X-linked_agammaglobulinemia wikiPageWikiLink Humoral_immunity.
• X-linked_agammaglobulinemia wikiPageWikiLink Hypogammaglobulinemia.
• X-linked_agammaglobulinemia wikiPageWikiLink Immune_system.
• X-linked_agammaglobulinemia wikiPageWikiLink Immunity_(medical).
• X-linked_agammaglobulinemia wikiPageWikiLink Immunodeficiency.
• X-linked_agammaglobulinemia wikiPageWikiLink Immunoglobulin_A.
• X-linked_agammaglobulinemia wikiPageWikiLink Immunoglobulin_D.
• X-linked_agammaglobulinemia wikiPageWikiLink Immunoglobulin_E.
• X-linked_agammaglobulinemia wikiPageWikiLink Immunoglobulin_G.
• X-linked_agammaglobulinemia wikiPageWikiLink Immunoglobulin_M.
• X-linked_agammaglobulinemia wikiPageWikiLink Immunoglobulin_therapy.
• X-linked_agammaglobulinemia wikiPageWikiLink Infection.
• X-linked_agammaglobulinemia wikiPageWikiLink Injection_(medicine).
• X-linked_agammaglobulinemia wikiPageWikiLink Intravenous_therapy.
• X-linked_agammaglobulinemia wikiPageWikiLink Laboratory_mouse.
• X-linked_agammaglobulinemia wikiPageWikiLink MMR_vaccine.
• X-linked_agammaglobulinemia wikiPageWikiLink Measles.
• X-linked_agammaglobulinemia wikiPageWikiLink Meningitis.
• X-linked_agammaglobulinemia wikiPageWikiLink Mumps.
• X-linked_agammaglobulinemia wikiPageWikiLink Ogden_Bruton.
• X-linked_agammaglobulinemia wikiPageWikiLink Passive_immunity.
• X-linked_agammaglobulinemia wikiPageWikiLink Pathogen.
• X-linked_agammaglobulinemia wikiPageWikiLink Picornavirus.
• X-linked_agammaglobulinemia wikiPageWikiLink Pleconaril.
• X-linked_agammaglobulinemia wikiPageWikiLink Polio_vaccine.
• X-linked_agammaglobulinemia wikiPageWikiLink Poliomyelitis.
• X-linked_agammaglobulinemia wikiPageWikiLink Poliovirus.
• X-linked_agammaglobulinemia wikiPageWikiLink Primary_immunodeficiency.
• X-linked_agammaglobulinemia wikiPageWikiLink Respiratory_tract.
• X-linked_agammaglobulinemia wikiPageWikiLink Rubella.
• X-linked_agammaglobulinemia wikiPageWikiLink Serology.
• X-linked_agammaglobulinemia wikiPageWikiLink Severe_combined_immunodeficiency.
• X-linked_agammaglobulinemia wikiPageWikiLink Sex_linkage.
• X-linked_agammaglobulinemia wikiPageWikiLink Symptom.
• X-linked_agammaglobulinemia wikiPageWikiLink Vaccine.
• X-linked_agammaglobulinemia wikiPageWikiLink Western_blot.
• X-linked_agammaglobulinemia wikiPageWikiLink X-linked_recessive_inheritance.
• X-linked_agammaglobulinemia wikiPageWikiLink X_chromosome.
• X-linked_agammaglobulinemia wikiPageWikiLink File:X-linked_recessive.svg.
• X-linked_agammaglobulinemia wikiPageWikiLinkText "IgG deficiency".
• X-linked_agammaglobulinemia wikiPageWikiLinkText "X-linked agammaglobulinemia".
• X-linked_agammaglobulinemia diseasesdb "1728".
• X-linked_agammaglobulinemia emedicinesubj "ped".
• X-linked_agammaglobulinemia emedicinetopic "294".
• X-linked_agammaglobulinemia icd "279.04".
• X-linked_agammaglobulinemia icd "D80.0".
• X-linked_agammaglobulinemia medlineplus "1307".
• X-linked_agammaglobulinemia name "X-linked agammaglobulinemia".
• X-linked_agammaglobulinemia omim "300300".
• X-linked_agammaglobulinemia wikiPageUsesTemplate Template:Citation_needed.
• X-linked_agammaglobulinemia wikiPageUsesTemplate Template:Deficiencies_of_intracellular_signaling_peptides_and_proteins.
• X-linked_agammaglobulinemia wikiPageUsesTemplate Template:EMedicine2.
• X-linked_agammaglobulinemia wikiPageUsesTemplate Template:Immune_disorders.
• X-linked_agammaglobulinemia wikiPageUsesTemplate Template:Infobox_disease.

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