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- Wolff–Chaikoff_effect abstract "The Wolff–Chaikoff effect (pronounced \"woolf' cha'kof\"), discovered by Drs. Jan Wolff and Israel Lyon Chaikoff at the University of California, is a reduction in thyroid hormone levels caused by ingestion of a large amount of iodine. In 1948, Wolff and Chaikoff reported that injection of iodine in rats almost completely inhibited organification (thyroglobulin iodination) in the thyroid gland. Patients with Graves' disease are more sensitive than euthyroid patients, and iodine has been used to manage Graves' disease.The Wolff–Chaikoff effect is an autoregulatory phenomenon that inhibits organification in the thyroid gland, the formation of thyroid hormones inside the thyroid follicle, and the release of thyroid hormones into the bloodstream. This becomes evident secondary to elevated levels of circulating iodide. The Wolff - Chaikoff effect is an effective means of rejecting a large quantity of imbibed iodide, and therefore preventing the thyroid from synthesizing large quantities of thyroid hormone. Excess iodide transiently inhibits thyroid iodide organification. In individuals with a normal thyroid, the gland eventually escapes from this inhibitory effect and iodide organification resumes; however, in patients with underlying autoimmune thyroid disease, the suppressive action of high iodide may persist. The Wolff–Chaikoff effect lasts several days (around 10 days), after which it is followed by an \"escape phenomenon,\" which is described by resumption of normal organification of iodine and normal thyroid peroxidase function. \"Escape phenomenon\" is believed to occur because of decreased inorganic iodine concentration secondary to down-regulation of sodium-iodide symporter (NIS) on the basolateral membrane of the thyroid follicular cell.The Wolff–Chaikoff effect can be used as a treatment principle against hyperthyroidism (especially thyroid storm) by infusion of a large amount of iodine to suppress the thyroid gland. Iodide was used to treat hyperthyroidism before antithyroid drugs such as propylthiouracil and methimazole were developed. Hyperthyroid subjects given iodide may experience a decrease in basal metabolic rate that is comparable to that seen after thyroidectomy. The Wolff–Chaikoff effect also explains the hypothyroidism produced in some patients by several iodine-containing drugs, including amiodarone. The Wolff–Chaikoff effect is also part of the mechanism for the use of potassium iodide in nuclear emergencies.".
- Wolff–Chaikoff_effect wikiPageID "2080144".
- Wolff–Chaikoff_effect wikiPageLength "7644".
- Wolff–Chaikoff_effect wikiPageOutDegree "22".
- Wolff–Chaikoff_effect wikiPageRevisionID "707324723".
- Wolff–Chaikoff_effect wikiPageWikiLink Amiodarone.
- Wolff–Chaikoff_effect wikiPageWikiLink Antithyroid_agent.
- Wolff–Chaikoff_effect wikiPageWikiLink Basal_metabolic_rate.
- Wolff–Chaikoff_effect wikiPageWikiLink Category:Iodine.
- Wolff–Chaikoff_effect wikiPageWikiLink Euthyroid.
- Wolff–Chaikoff_effect wikiPageWikiLink Graves_disease.
- Wolff–Chaikoff_effect wikiPageWikiLink Hyperthyroidism.
- Wolff–Chaikoff_effect wikiPageWikiLink Hypothyroidism.
- Wolff–Chaikoff_effect wikiPageWikiLink Iodide.
- Wolff–Chaikoff_effect wikiPageWikiLink Iodine.
- Wolff–Chaikoff_effect wikiPageWikiLink Jod-Basedow_phenomenon.
- Wolff–Chaikoff_effect wikiPageWikiLink Lugols_iodine.
- Wolff–Chaikoff_effect wikiPageWikiLink Methimazole.
- Wolff–Chaikoff_effect wikiPageWikiLink Organification.
- Wolff–Chaikoff_effect wikiPageWikiLink Potassium_iodide.
- Wolff–Chaikoff_effect wikiPageWikiLink Propylthiouracil.
- Wolff–Chaikoff_effect wikiPageWikiLink Sodium-iodide_symporter.
- Wolff–Chaikoff_effect wikiPageWikiLink Thyroid.
- Wolff–Chaikoff_effect wikiPageWikiLink Thyroid_hormone.
- Wolff–Chaikoff_effect wikiPageWikiLink Thyroid_storm.
- Wolff–Chaikoff_effect wikiPageWikiLink Thyroidectomy.
- Wolff–Chaikoff_effect wikiPageWikiLinkText "Wolff–Chaikoff effect".
- Wolff–Chaikoff_effect wikiPageWikiLinkText "Wolff–Chaikoff_effect".
- Wolff–Chaikoff_effect wikiPageUsesTemplate Template:Endocrinology.
- Wolff–Chaikoff_effect wikiPageUsesTemplate Template:Reflist.
- Wolff–Chaikoff_effect subject Category:Iodine.
- Wolff–Chaikoff_effect type Antiseptic.
- Wolff–Chaikoff_effect type Element.
- Wolff–Chaikoff_effect type Redirect.
- Wolff–Chaikoff_effect comment "The Wolff–Chaikoff effect (pronounced \"woolf' cha'kof\"), discovered by Drs. Jan Wolff and Israel Lyon Chaikoff at the University of California, is a reduction in thyroid hormone levels caused by ingestion of a large amount of iodine. In 1948, Wolff and Chaikoff reported that injection of iodine in rats almost completely inhibited organification (thyroglobulin iodination) in the thyroid gland.".
- Wolff–Chaikoff_effect label "Wolff–Chaikoff effect".
- Wolff–Chaikoff_effect sameAs Q2352460.
- Wolff–Chaikoff_effect sameAs Efecto_de_Wolff–Chaikoff.
- Wolff–Chaikoff_effect sameAs Effetto_Wolff-Chaikoff.
- Wolff–Chaikoff_effect sameAs Efekt_Wolffa-Chaikoffa.
- Wolff–Chaikoff_effect sameAs Efeito_Wolff–Chaikoff.
- Wolff–Chaikoff_effect sameAs m.06kskl.
- Wolff–Chaikoff_effect sameAs Wolff-Chaikoffs_effekt.
- Wolff–Chaikoff_effect sameAs Ефект_Вольфа_—_Чайкова.
- Wolff–Chaikoff_effect sameAs Q2352460.
- Wolff–Chaikoff_effect wasDerivedFrom Wolff–Chaikoff_effect?oldid=707324723.
- Wolff–Chaikoff_effect isPrimaryTopicOf Wolff–Chaikoff_effect.