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- WAY-200070 abstract "WAY-200070 is a synthetic, non-steroidal, highly selective agonist of ERβ. It possesses 68-fold selectivity for ERβ over ERα (EC50 = 2 nM and 155 nM, respectively). WAY-200070 has been found to enhance serotonergic and dopaminergic neurotransmission in the central nervous system, and produces antidepressant- and anxiolytic-like effects in animals. It has been proposed as a potential novel antidepressant/anxiolytic agent. WAY-200070 has also been found to produce antidiabetic effects in animals, and may also be beneficial for the treatment of certain inflammatory conditions.Due to its selectivity for ERβ, WAY-200070 is inactive in various assays of classic estrogen action, such as uterotrophic and osteopenia. Moreover, WAY-200070 does not affect luteinizing hormone or follicle-stimulating hormone or inhibit ovulation, indicating that it does not suppress the hypothalamic-pituitary-gonadal axis, and as ERα and not ERβ is implicated in breast development, would not be expected to cause growth of the breasts at doses that are selective for activation of ERβ. In fact, ERβ activation may actually suppress breast growth, and in accordance with this, WAY-200070 was shown to augment the efficacy of tamoxifen in in vitro models of breast cancer. As such, WAY-200070 and other selective ERβ agonists might prove to be safe and tolerable for medical use in both premenopausal and postmenopausal women and in individuals of either sex.".
- WAY-200070 atcPrefix "None".
- WAY-200070 casNumber "440122-66-7".
- WAY-200070 iupacName "4-(7-bromo-5-hydroxy-3H-1,3-benzoxazol-2-ylidene)cyclohexa-2,5-dien-1-one".
- WAY-200070 pubchem "9861330".
- WAY-200070 thumbnail WAY-200070.svg?width=300.
- WAY-200070 wikiPageID "48970070".
- WAY-200070 wikiPageLength "5371".
- WAY-200070 wikiPageOutDegree "36".
- WAY-200070 wikiPageRevisionID "698936662".
- WAY-200070 wikiPageWikiLink Agonist.
- WAY-200070 wikiPageWikiLink Anti-diabetic_medication.
- WAY-200070 wikiPageWikiLink Antidepressant.
- WAY-200070 wikiPageWikiLink Anxiolytic.
- WAY-200070 wikiPageWikiLink Breast_cancer.
- WAY-200070 wikiPageWikiLink Breast_development.
- WAY-200070 wikiPageWikiLink Category:Alcohols.
- WAY-200070 wikiPageWikiLink Category:Antidepressants.
- WAY-200070 wikiPageWikiLink Category:Anxiolytics.
- WAY-200070 wikiPageWikiLink Category:Benzoxazoles.
- WAY-200070 wikiPageWikiLink Category:Ketones.
- WAY-200070 wikiPageWikiLink Category:Organobromides.
- WAY-200070 wikiPageWikiLink Category:Selective_ERβ_agonists.
- WAY-200070 wikiPageWikiLink Central_nervous_system.
- WAY-200070 wikiPageWikiLink Dopaminergic.
- WAY-200070 wikiPageWikiLink EC50.
- WAY-200070 wikiPageWikiLink Estrogen.
- WAY-200070 wikiPageWikiLink Estrogen_receptor_alpha.
- WAY-200070 wikiPageWikiLink Estrogen_receptor_beta.
- WAY-200070 wikiPageWikiLink Follicle-stimulating_hormone.
- WAY-200070 wikiPageWikiLink Hypothalamic–pituitary–gonadal_axis.
- WAY-200070 wikiPageWikiLink Inflammatory.
- WAY-200070 wikiPageWikiLink Liquiritigenin.
- WAY-200070 wikiPageWikiLink Luteinizing_hormone.
- WAY-200070 wikiPageWikiLink Menerba.
- WAY-200070 wikiPageWikiLink Menopause.
- WAY-200070 wikiPageWikiLink Neurotransmission.
- WAY-200070 wikiPageWikiLink Nonsteroidal.
- WAY-200070 wikiPageWikiLink Organic_compound.
- WAY-200070 wikiPageWikiLink Osteopenia.
- WAY-200070 wikiPageWikiLink Ovulation.
- WAY-200070 wikiPageWikiLink Prinaberel.
- WAY-200070 wikiPageWikiLink Serotonergic.
- WAY-200070 wikiPageWikiLink Tamoxifen.
- WAY-200070 wikiPageWikiLink Uterus.
- WAY-200070 wikiPageWikiLinkText "WAY-200070".
- WAY-200070 atcPrefix "None".
- WAY-200070 br "1".
- WAY-200070 c "13".
- WAY-200070 casNumber "440122".
- WAY-200070 chemspiderid "11193044".
- WAY-200070 h "8".
- WAY-200070 inchi "InChI=1S/C13H8BrNO3/c14-10-5-96-11-1218-137-1-3-84-2-7/h1-6,15,17H".
- WAY-200070 inchikey "IVFWABSHZFOMIG-UHFFFAOYSA-N".
- WAY-200070 iupacName "4".
- WAY-200070 molecularWeight "306.11152".
- WAY-200070 n "1".
- WAY-200070 o "3".
- WAY-200070 pubchem "9861330".
- WAY-200070 smiles "C1=CCC=CC1=C2NC3=CCO".
- WAY-200070 stdinchi "1".
- WAY-200070 stdinchikey "IVFWABSHZFOMIG-UHFFFAOYSA-N".
- WAY-200070 wikiPageUsesTemplate Template:Drugbox.
- WAY-200070 wikiPageUsesTemplate Template:Estrogenics.
- WAY-200070 wikiPageUsesTemplate Template:Pharmacology-stub.
- WAY-200070 wikiPageUsesTemplate Template:Reflist.
- WAY-200070 subject Category:Alcohols.
- WAY-200070 subject Category:Antidepressants.
- WAY-200070 subject Category:Anxiolytics.
- WAY-200070 subject Category:Benzoxazoles.
- WAY-200070 subject Category:Ketones.
- WAY-200070 subject Category:Organobromides.
- WAY-200070 subject Category:Selective_ERβ_agonists.
- WAY-200070 type ChemicalSubstance.
- WAY-200070 type Drug.
- WAY-200070 type ChemicalObject.
- WAY-200070 type Thing.
- WAY-200070 type Q8386.
- WAY-200070 comment "WAY-200070 is a synthetic, non-steroidal, highly selective agonist of ERβ. It possesses 68-fold selectivity for ERβ over ERα (EC50 = 2 nM and 155 nM, respectively). WAY-200070 has been found to enhance serotonergic and dopaminergic neurotransmission in the central nervous system, and produces antidepressant- and anxiolytic-like effects in animals. It has been proposed as a potential novel antidepressant/anxiolytic agent.".
- WAY-200070 label "WAY-200070".
- WAY-200070 wasDerivedFrom WAY-200070?oldid=698936662.
- WAY-200070 depiction WAY-200070.svg.
- WAY-200070 isPrimaryTopicOf WAY-200070.