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- Valerenic_acid abstract "Valerenic acid is a sesquiterpenoid constituent of the essential oil of the Valerian plant. Not to be confused with valeric acid or valproic acid, which are related to each other and are anticonvulsants.Valerian is used as a herbal sedative which may be helpful in the treatment of insomnia.The precise mechanism of this action has not been established. It is likely that several different components of the plant contribute to the effect. Valerenic acid is thought to be at least partly responsible for the sedative effects.A study in 2004 found valerenic acid to act as a subtype-selective GABAA receptor positive allosteric modulator in neonatal rat brainstem preparations. The mechanism of this action could not be elucidated in this study.A study in 2007 on GABA receptors of various composition, expressed in Xenopus oocytes (frog eggs), found valerenic acid to act mainly at α1β2 and α1β3 subtypes of these receptors. Only channels incorporating β2 or β3 subunits were stimulated by valerenic acid. Modulation of ion channel action was not significantly dependent on incorporation of α1, α2, α3 or α5 subunits.A study in 2005, in vitro (receptor material not specified in abstract), found valerian extract as well as valerenic acid to be 5-HT5A receptor (serotonin receptor) partial agonists.Part of the binding studies focused on the 5HT5A receptor, which is distributed in the suprachiasmatic nucleus. This is a tiny region of the brain, which is implicated in the sleep-wake cycle.A study in 2006 found valerian extract as well as valerenic acid to inhibit NF-κB, a protein complex that controls the transcription of DNA, in HeLa (cultured human cancer) cells. This was measured with the IL-6 / Luc (Interleukin-6 luciferase) assay as a measurement tool. The study mentioned that such inhibition may be connected to the reported anti-inflammatory action of the valerian plant.".
- Valerenic_acid iupacName "(2E)-3-[(4S,7R,7aR)-3,7-dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl]-2-methylacrylic acid".
- Valerenic_acid thumbnail Valerenic_acid.svg?width=300.
- Valerenic_acid wikiPageID "12681229".
- Valerenic_acid wikiPageLength "5834".
- Valerenic_acid wikiPageOutDegree "23".
- Valerenic_acid wikiPageRevisionID "679029723".
- Valerenic_acid wikiPageWikiLink 5-HT_receptor.
- Valerenic_acid wikiPageWikiLink Allosteric_modulator.
- Valerenic_acid wikiPageWikiLink Anti-inflammatory.
- Valerenic_acid wikiPageWikiLink Category:GABAA_receptor_positive_allosteric_modulators.
- Valerenic_acid wikiPageWikiLink Category:Sedatives.
- Valerenic_acid wikiPageWikiLink Category:Serotonin_receptor_agonists.
- Valerenic_acid wikiPageWikiLink Circadian_rhythm.
- Valerenic_acid wikiPageWikiLink DNA.
- Valerenic_acid wikiPageWikiLink GABAA_receptor.
- Valerenic_acid wikiPageWikiLink HeLa.
- Valerenic_acid wikiPageWikiLink Insomnia.
- Valerenic_acid wikiPageWikiLink Interleukin_6.
- Valerenic_acid wikiPageWikiLink Luciferase.
- Valerenic_acid wikiPageWikiLink NF-κB.
- Valerenic_acid wikiPageWikiLink Oocyte.
- Valerenic_acid wikiPageWikiLink Sedative.
- Valerenic_acid wikiPageWikiLink Sesquiterpene.
- Valerenic_acid wikiPageWikiLink Suprachiasmatic_nucleus.
- Valerenic_acid wikiPageWikiLink Transcription_(genetics).
- Valerenic_acid wikiPageWikiLink Valerian_(herb).
- Valerenic_acid wikiPageWikiLink Valeric_acid.
- Valerenic_acid wikiPageWikiLink Valproate.
- Valerenic_acid wikiPageWikiLink Xenopus.
- Valerenic_acid wikiPageWikiLinkText "Valerenic Acid".
- Valerenic_acid wikiPageWikiLinkText "Valerenic acid".
- Valerenic_acid wikiPageWikiLinkText "valerenic acid".
- Valerenic_acid imagefile "Valerenic acid3Dan.gif".
- Valerenic_acid imagefile "Valerenic_acid.svg".
- Valerenic_acid imagesize "150".
- Valerenic_acid imagesize "250".
- Valerenic_acid iupacname "-3".
- Valerenic_acid verifiedfields "changed".
- Valerenic_acid verifiedrevid "470627804".
- Valerenic_acid wikiPageUsesTemplate Template:Cascite.
- Valerenic_acid wikiPageUsesTemplate Template:Chembox.
- Valerenic_acid wikiPageUsesTemplate Template:Chembox_Hazards.
- Valerenic_acid wikiPageUsesTemplate Template:Chembox_Identifiers.
- Valerenic_acid wikiPageUsesTemplate Template:Chembox_Properties.
- Valerenic_acid wikiPageUsesTemplate Template:Chemspidercite.
- Valerenic_acid wikiPageUsesTemplate Template:Ebicite.
- Valerenic_acid wikiPageUsesTemplate Template:GABAAR_PAMs.
- Valerenic_acid wikiPageUsesTemplate Template:Reflist.
- Valerenic_acid wikiPageUsesTemplate Template:Sedative-stub.
- Valerenic_acid wikiPageUsesTemplate Template:Sedatives.
- Valerenic_acid wikiPageUsesTemplate Template:Serotonergics.
- Valerenic_acid wikiPageUsesTemplate Template:Stdinchicite.
- Valerenic_acid subject Category:GABAA_receptor_positive_allosteric_modulators.
- Valerenic_acid subject Category:Sedatives.
- Valerenic_acid subject Category:Serotonin_receptor_agonists.
- Valerenic_acid hypernym Constituent.
- Valerenic_acid type ChemicalCompound.
- Valerenic_acid type ChemicalSubstance.
- Valerenic_acid type Drug.
- Valerenic_acid type Agonist.
- Valerenic_acid type Drug.
- Valerenic_acid type ChemicalObject.
- Valerenic_acid type Thing.
- Valerenic_acid type Q11173.
- Valerenic_acid comment "Valerenic acid is a sesquiterpenoid constituent of the essential oil of the Valerian plant. Not to be confused with valeric acid or valproic acid, which are related to each other and are anticonvulsants.Valerian is used as a herbal sedative which may be helpful in the treatment of insomnia.The precise mechanism of this action has not been established. It is likely that several different components of the plant contribute to the effect.".
- Valerenic_acid label "Valerenic acid".
- Valerenic_acid sameAs Q75850.
- Valerenic_acid sameAs Valerensäure.
- Valerenic_acid sameAs Ácido_valerenico.
- Valerenic_acid sameAs والرنیک_اسید.
- Valerenic_acid sameAs Acido_valerenico.
- Valerenic_acid sameAs Kwas_walerenowy.
- Valerenic_acid sameAs m.02x0931.
- Valerenic_acid sameAs Valerenska_kiselina.
- Valerenic_acid sameAs Valerenska_kiselina.
- Valerenic_acid sameAs Q75850.
- Valerenic_acid wasDerivedFrom Valerenic_acid?oldid=679029723.
- Valerenic_acid depiction Valerenic_acid.svg.
- Valerenic_acid isPrimaryTopicOf Valerenic_acid.