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- Unfolded_protein_response abstract "The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER). It is a stress response that has been found to be conserved between all mammalian species, as well as yeast and worm organisms. This article focuses on the mammalian response.The UPR is activated in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum. In this scenario, the UPR has three aims: initially to restore normal function of the cell by halting protein translation, degrading misfolded proteins, and activating the signaling pathways that lead to increasing the production of molecular chaperones involved in protein folding. If these objectives are not achieved within a certain time span or the disruption is prolonged, the UPR aims towards apoptosis.Sustained overactivation of the UPR has been implicated in prion diseases as well as several other neurodegenerative diseases, and inhibiting the UPR could become a treatment for those diseases. Diseases amenable to UPR inhibition include Creutzfeldt-Jakob disease, Alzheimer's disease, Parkinson's disease, and Huntington's disease.".
- Unfolded_protein_response wikiPageID "9941789".
- Unfolded_protein_response wikiPageLength "22915".
- Unfolded_protein_response wikiPageOutDegree "58".
- Unfolded_protein_response wikiPageRevisionID "708110846".
- Unfolded_protein_response wikiPageWikiLink 2-Deoxy-D-glucose.
- Unfolded_protein_response wikiPageWikiLink A23187.
- Unfolded_protein_response wikiPageWikiLink Alzheimers_disease.
- Unfolded_protein_response wikiPageWikiLink Apoptosis.
- Unfolded_protein_response wikiPageWikiLink Autophosphorylation.
- Unfolded_protein_response wikiPageWikiLink Binding_immunoglobulin_protein.
- Unfolded_protein_response wikiPageWikiLink Bortezomib.
- Unfolded_protein_response wikiPageWikiLink Brefeldin_A.
- Unfolded_protein_response wikiPageWikiLink CEBPE.
- Unfolded_protein_response wikiPageWikiLink Calnexin.
- Unfolded_protein_response wikiPageWikiLink Calreticulin.
- Unfolded_protein_response wikiPageWikiLink Category:Proteins.
- Unfolded_protein_response wikiPageWikiLink Cellular_stress_response.
- Unfolded_protein_response wikiPageWikiLink Chaperone_(protein).
- Unfolded_protein_response wikiPageWikiLink Creutzfeldt–Jakob_disease.
- Unfolded_protein_response wikiPageWikiLink Degradative_enzyme.
- Unfolded_protein_response wikiPageWikiLink Dithiothreitol.
- Unfolded_protein_response wikiPageWikiLink EIF2AK3.
- Unfolded_protein_response wikiPageWikiLink ERN1.
- Unfolded_protein_response wikiPageWikiLink Endoplasmic-reticulum-associated_protein_degradation.
- Unfolded_protein_response wikiPageWikiLink Endoplasmic_reticulum.
- Unfolded_protein_response wikiPageWikiLink Enzyme.
- Unfolded_protein_response wikiPageWikiLink File:PROTEIN_FOLDING_SIMPLIFIED_JPEG_small.jpg.
- Unfolded_protein_response wikiPageWikiLink File:UPR_simplified_JPEG.jpg.
- Unfolded_protein_response wikiPageWikiLink HLA-B27.
- Unfolded_protein_response wikiPageWikiLink Huntingtons_disease.
- Unfolded_protein_response wikiPageWikiLink Interleukin_10.
- Unfolded_protein_response wikiPageWikiLink Lumen_(anatomy).
- Unfolded_protein_response wikiPageWikiLink Mammal.
- Unfolded_protein_response wikiPageWikiLink N-linked_glycosylation.
- Unfolded_protein_response wikiPageWikiLink Neurodegeneration.
- Unfolded_protein_response wikiPageWikiLink Oligomer.
- Unfolded_protein_response wikiPageWikiLink PERK_inhibitors.
- Unfolded_protein_response wikiPageWikiLink Parkinsons_disease.
- Unfolded_protein_response wikiPageWikiLink Peptide.
- Unfolded_protein_response wikiPageWikiLink Prion.
- Unfolded_protein_response wikiPageWikiLink Protein.
- Unfolded_protein_response wikiPageWikiLink Protein_disulfide-isomerase.
- Unfolded_protein_response wikiPageWikiLink Protein_folding.
- Unfolded_protein_response wikiPageWikiLink RNA.
- Unfolded_protein_response wikiPageWikiLink Ribosome.
- Unfolded_protein_response wikiPageWikiLink Signal_recognition_particle.
- Unfolded_protein_response wikiPageWikiLink Thapsigargin.
- Unfolded_protein_response wikiPageWikiLink Translation_(biology).
- Unfolded_protein_response wikiPageWikiLink Translocon.
- Unfolded_protein_response wikiPageWikiLink Tumor_necrosis_factors.
- Unfolded_protein_response wikiPageWikiLink Tunicamycin.
- Unfolded_protein_response wikiPageWikiLink UGGT.
- Unfolded_protein_response wikiPageWikiLink XBP1.
- Unfolded_protein_response wikiPageWikiLink Yeast.
- Unfolded_protein_response wikiPageWikiLinkText "UPR".
- Unfolded_protein_response wikiPageWikiLinkText "Unfolded protein response".
- Unfolded_protein_response wikiPageWikiLinkText "endoplasmic reticular stress".
- Unfolded_protein_response wikiPageWikiLinkText "endoplasmic reticulum stress".
- Unfolded_protein_response wikiPageWikiLinkText "unfolded protein response".
- Unfolded_protein_response wikiPageWikiLinkText "unfolded proteins".
- Unfolded_protein_response wikiPageUsesTemplate Template:Cite_journal.
- Unfolded_protein_response wikiPageUsesTemplate Template:More_footnotes.
- Unfolded_protein_response wikiPageUsesTemplate Template:Reflist.
- Unfolded_protein_response subject Category:Proteins.
- Unfolded_protein_response hypernym Response.
- Unfolded_protein_response type Biomolecule.
- Unfolded_protein_response type Disease.
- Unfolded_protein_response type Biomolecule.
- Unfolded_protein_response type Nutrient.
- Unfolded_protein_response comment "The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER). It is a stress response that has been found to be conserved between all mammalian species, as well as yeast and worm organisms. This article focuses on the mammalian response.The UPR is activated in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum.".
- Unfolded_protein_response label "Unfolded protein response".
- Unfolded_protein_response sameAs Q2601436.
- Unfolded_protein_response sameAs استجابة_البروتين_غير_المطوي.
- Unfolded_protein_response sameAs Unfolded_Protein_Response.
- Unfolded_protein_response sameAs Respuesta_a_proteínas_desplegadas.
- Unfolded_protein_response sameAs Unfolded_protein_response.
- Unfolded_protein_response sameAs 小胞体ストレス.
- Unfolded_protein_response sameAs Resposta_a_proteínas_mal_enoveladas.
- Unfolded_protein_response sameAs m.02pxnxf.
- Unfolded_protein_response sameAs Відповідь_на_незгорнуті_білки.
- Unfolded_protein_response sameAs Q2601436.
- Unfolded_protein_response wasDerivedFrom Unfolded_protein_response?oldid=708110846.
- Unfolded_protein_response isPrimaryTopicOf Unfolded_protein_response.