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- Trinder_spot_test abstract "The Trinder spot test is a diagnostic test used in medicine to determine exposure to salicylates, particularly to salicylic acid. The test employs the Trinder reagent (a.k.a. Trinder solution) which is mixed with a patient's urine. The colour change, resulting from the Trinder reaction, is immediate, enabling rapid bedside assessment.The Trinder solution/reagent is a pre-mixed solution of 10% ferric chloride. It can be prepared by combining 40 g of mercuric chloride and 40 g of ferric nitrate in 850 ml of type II deionized water, and then adding 10 ml of concentrated hydrochloric acid to the solution and diluting to a volume of 1 litre with more type II deionized water.The test for the Trinder reaction is to mix 1 ml of urine with 1 ml of the Trinder reagent in a test tube. The test is positive if a colour change results. The specific colour changes are:blue or purplepositive testno changenegative testbrownfalse-positive test caused by the presence of phenothiazinesThe test has a sensitivity of 94% and a specificity of 74% for identifying patients whose salicylate concentrations are greater than 30 mg per decilitre (2.17 mmol/L). False positive concentrations (2.8 to 14.3 mg per decilitre) have been reported to occur in neonates with hyperbilirubinemia, premature neonates, and children who are seriously ill (e.g. children who have extensive burns).The reaction between iron(III) and pharmaceuticals was first adapted for clinical use by P. Trinder (after whom the test, reaction, and reagent are now named), of the Biochemistry Department of the Royal Infirmary in Sunderland, in 1954 (see the article listed in further reading). Salicyclic acid, salicylamide, and methylsalicylate all react with iron(III) via the phenol group which is next to their –COOH, –CONH2, or –COOCH3 functions. The Trinder reaction has been used for the determination of the presence of oxytetracycline in 1991, of ciprofloxacin in 1992, and of norfloxacin in 1993, in each case using a solution of iron(III) in suplphuric acid. It has also been used for the determination of the presence of bromazepan in 1992, using an iron(II) solution in a hydrochloric acid rather than an iron(III) solution.".
- Trinder_spot_test wikiPageID "22785324".
- Trinder_spot_test wikiPageLength "4927".
- Trinder_spot_test wikiPageOutDegree "22".
- Trinder_spot_test wikiPageRevisionID "707585103".
- Trinder_spot_test wikiPageWikiLink Bilirubin.
- Trinder_spot_test wikiPageWikiLink Bromazepam.
- Trinder_spot_test wikiPageWikiLink Category:Medical_tests.
- Trinder_spot_test wikiPageWikiLink Ciprofloxacin.
- Trinder_spot_test wikiPageWikiLink Hydrochloric_acid.
- Trinder_spot_test wikiPageWikiLink Iron(III)_chloride.
- Trinder_spot_test wikiPageWikiLink Iron(III)_nitrate.
- Trinder_spot_test wikiPageWikiLink Mercury(II)_chloride.
- Trinder_spot_test wikiPageWikiLink Methyl_salicylate.
- Trinder_spot_test wikiPageWikiLink Norfloxacin.
- Trinder_spot_test wikiPageWikiLink Oxytetracycline.
- Trinder_spot_test wikiPageWikiLink Phenothiazine.
- Trinder_spot_test wikiPageWikiLink Purified_water.
- Trinder_spot_test wikiPageWikiLink Royal_Infirmary.
- Trinder_spot_test wikiPageWikiLink Salicylamide.
- Trinder_spot_test wikiPageWikiLink Salicylate_testing.
- Trinder_spot_test wikiPageWikiLink Salicylic_acid.
- Trinder_spot_test wikiPageWikiLink Sunderland,_Tyne_and_Wear.
- Trinder_spot_test wikiPageWikiLink Test_tube.
- Trinder_spot_test wikiPageWikiLink Urine.
- Trinder_spot_test wikiPageWikiLinkText "Trinder spot test".
- Trinder_spot_test wikiPageUsesTemplate Template:About.
- Trinder_spot_test wikiPageUsesTemplate Template:Biochem-stub.
- Trinder_spot_test wikiPageUsesTemplate Template:Cite_journal.
- Trinder_spot_test wikiPageUsesTemplate Template:Med-diagnostic-stub.
- Trinder_spot_test subject Category:Medical_tests.
- Trinder_spot_test hypernym Test.
- Trinder_spot_test type Cricketer.
- Trinder_spot_test type Reagent.
- Trinder_spot_test comment "The Trinder spot test is a diagnostic test used in medicine to determine exposure to salicylates, particularly to salicylic acid. The test employs the Trinder reagent (a.k.a. Trinder solution) which is mixed with a patient's urine. The colour change, resulting from the Trinder reaction, is immediate, enabling rapid bedside assessment.The Trinder solution/reagent is a pre-mixed solution of 10% ferric chloride.".
- Trinder_spot_test label "Trinder spot test".
- Trinder_spot_test sameAs Q7842334.
- Trinder_spot_test sameAs m.05zy328.
- Trinder_spot_test sameAs Q7842334.
- Trinder_spot_test wasDerivedFrom Trinder_spot_test?oldid=707585103.
- Trinder_spot_test isPrimaryTopicOf Trinder_spot_test.