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- Toca_511_&_Toca_FC abstract "Toca 511 and Toca FC, developed by Tocagen, is a combination treatment currently being investigated in phase I/II trials for recurrent high grade glioma including the notoriously difficult to treat glioblastoma multiforme. Toca 511 (vocimagene amiretrorepvec) is a nonlytic retroviral replicating vector (RRV) that encodes the transgene cytosine deaminase (CD). This enzyme is used to catalyze the conversion of Toca FC, a novel oral extended-release prodrug 5-fluorocytosine (5-FC) to the active 5-fluorouracil (5-FU). Intravenous or intracranial injection of Toca 511 takes place during initial treatment and 3-7 weeks later the patient starts cyclic administration of Toca FC.1,2,3 The phase I/II trials in humans have shown similar results of patients exceeding the average life expectancy of high grade gliomas.4".
- Toca_511_&_Toca_FC wikiPageExternalLink NCT01156584.
- Toca_511_&_Toca_FC wikiPageExternalLink NCT01470794.
- Toca_511_&_Toca_FC wikiPageExternalLink NCT01985256.
- Toca_511_&_Toca_FC wikiPageExternalLink tocagen-doses-first-patient-intravenously-in-clinical-trial-of-selective-cancer-therapy-toca-511-toca-fc.
- Toca_511_&_Toca_FC wikiPageID "31736125".
- Toca_511_&_Toca_FC wikiPageLength "7748".
- Toca_511_&_Toca_FC wikiPageOutDegree "12".
- Toca_511_&_Toca_FC wikiPageRevisionID "699801190".
- Toca_511_&_Toca_FC wikiPageWikiLink Category:Articles_created_via_the_Article_Wizard.
- Toca_511_&_Toca_FC wikiPageWikiLink Category:Experimental_medical_treatments.
- Toca_511_&_Toca_FC wikiPageWikiLink Cytosine_deaminase.
- Toca_511_&_Toca_FC wikiPageWikiLink Flucytosine.
- Toca_511_&_Toca_FC wikiPageWikiLink Fluorouracil.
- Toca_511_&_Toca_FC wikiPageWikiLink Glioblastoma_multiforme.
- Toca_511_&_Toca_FC wikiPageWikiLink Glioma.
- Toca_511_&_Toca_FC wikiPageWikiLink Murine_leukemia_virus.
- Toca_511_&_Toca_FC wikiPageWikiLink Retrovirus.
- Toca_511_&_Toca_FC wikiPageWikiLink T_cell.
- Toca_511_&_Toca_FC wikiPageWikiLink Transgene.
- Toca_511_&_Toca_FC wikiPageWikiLink Viral_vector.
- Toca_511_&_Toca_FC wikiPageWikiLinkText "Toca 511 & Toca FC".
- Toca_511_&_Toca_FC wikiPageUsesTemplate Template:As_of.
- Toca_511_&_Toca_FC subject Category:Articles_created_via_the_Article_Wizard.
- Toca_511_&_Toca_FC subject Category:Experimental_medical_treatments.
- Toca_511_&_Toca_FC hypernym Treatment.
- Toca_511_&_Toca_FC type Drug.
- Toca_511_&_Toca_FC comment "Toca 511 and Toca FC, developed by Tocagen, is a combination treatment currently being investigated in phase I/II trials for recurrent high grade glioma including the notoriously difficult to treat glioblastoma multiforme. Toca 511 (vocimagene amiretrorepvec) is a nonlytic retroviral replicating vector (RRV) that encodes the transgene cytosine deaminase (CD).".
- Toca_511_&_Toca_FC label "Toca 511 & Toca FC".
- Toca_511_&_Toca_FC sameAs Q7811936.
- Toca_511_&_Toca_FC sameAs Toca_511_i_Toca_FC.
- Toca_511_&_Toca_FC sameAs m.0gtvbks.
- Toca_511_&_Toca_FC sameAs Q7811936.
- Toca_511_&_Toca_FC wasDerivedFrom Toca_511_&_Toca_FC?oldid=699801190.
- Toca_511_&_Toca_FC isPrimaryTopicOf Toca_511_&_Toca_FC.