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- Tinman_gene abstract "Tinman gene tinman is an Nk-homeobox gene that is responsible for the differentiation, proliferation, and specification of cardiac progenitor cells. Homeobox genes are a group of transcription factors characterized by a homeodomain that initiates gene expression which regulates cell differentiation and development when it binds to a target promoter. tinman was fist isolated in Drosophila and many vertebrate homologs have been discovered since and are considered part of a multigene family in vertebrates.tinman is expressed very early in Drosophila during the development of the embryonic mesoderm and is required for formation of the visceral and cardiac mesoderm. It is expressed transiently in the visceral mesoderm but continues to be expressed in the cardiac mesoderm. The two major cell types of the Drosophila heart, cardial and pericardial cells, express tinman.In both Drosophila and vertebrates, the temporal and spatial expression of tinman is critical in determining cell lineage and patterning of the heart. In mutant or knockout organisms, the loss of tinman results in the lack of heart formation. In humans, NKX2.5 is the homolog to tinman and mutations to or arising from this gene are some of the most common congenital heart defects. These include atrial and ventricular septal defects and tetralogy of Fallot.".
- Tinman_gene wikiPageID "42493759".
- Tinman_gene wikiPageLength "3384".
- Tinman_gene wikiPageOutDegree "18".
- Tinman_gene wikiPageRevisionID "618341297".
- Tinman_gene wikiPageWikiLink Atrium_(heart).
- Tinman_gene wikiPageWikiLink Category:Genes.
- Tinman_gene wikiPageWikiLink Cell_growth.
- Tinman_gene wikiPageWikiLink Cellular_differentiation.
- Tinman_gene wikiPageWikiLink Congenital_heart_defect.
- Tinman_gene wikiPageWikiLink Drosophila.
- Tinman_gene wikiPageWikiLink Gene_expression.
- Tinman_gene wikiPageWikiLink Heart.
- Tinman_gene wikiPageWikiLink Homeobox.
- Tinman_gene wikiPageWikiLink Homology_(biology).
- Tinman_gene wikiPageWikiLink Mesoderm.
- Tinman_gene wikiPageWikiLink Pericardium.
- Tinman_gene wikiPageWikiLink Progenitor_cell.
- Tinman_gene wikiPageWikiLink Promoter_(genetics).
- Tinman_gene wikiPageWikiLink Tetralogy_of_Fallot.
- Tinman_gene wikiPageWikiLink Transcription_factor.
- Tinman_gene wikiPageWikiLink Ventricular_septal_defect.
- Tinman_gene wikiPageWikiLink Vertebrate.
- Tinman_gene wikiPageUsesTemplate Template:Reflist.
- Tinman_gene subject Category:Genes.
- Tinman_gene hypernym Gene.
- Tinman_gene type Protein.
- Tinman_gene comment "Tinman gene tinman is an Nk-homeobox gene that is responsible for the differentiation, proliferation, and specification of cardiac progenitor cells. Homeobox genes are a group of transcription factors characterized by a homeodomain that initiates gene expression which regulates cell differentiation and development when it binds to a target promoter.".
- Tinman_gene label "Tinman gene".
- Tinman_gene sameAs Q17142087.
- Tinman_gene sameAs m.010f5pp1.
- Tinman_gene sameAs Q17142087.
- Tinman_gene wasDerivedFrom Tinman_gene?oldid=618341297.
- Tinman_gene isPrimaryTopicOf Tinman_gene.