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- Tg-rasH2_mouse abstract "A Tg-rasH2 mouse is an innovative transgenic mouse, developed in Central Institute for Experimental Animals (CIEA), carrying the three copies of human prototype c-Ha-ras oncogenes with endogenous promoter and enhancer in tandem. Under Alternative Carcinogenicity Testing (ACT) project conducted by International Life Sciences Institute (ILSI) and ILSI Health and Environmental Sciences Institute (HESI), comprehensive evaluation studies on the Tg-rasH2 mouse bioassay system were performed and the usefulness of the system was validated for carcinogenicity studies by 23 international pharmaceutical companies. In the studies, it was confirmed that Tg-rasH2 mice are sensitive to both genotoxic and non-genotoxic human carcinogens and show no response to non-carcinogens. As a consequence, the Tg-rasH2 mice have been accepted as a short-term carcinogenicity study system enabling to reduce the conventional two-year study period to 26 weeks.".
- Tg-rasH2_mouse wikiPageExternalLink A1_R&D_rasH2.htm.
- Tg-rasH2_mouse wikiPageID "16143273".
- Tg-rasH2_mouse wikiPageLength "1855".
- Tg-rasH2_mouse wikiPageOutDegree "5".
- Tg-rasH2_mouse wikiPageRevisionID "687925508".
- Tg-rasH2_mouse wikiPageWikiLink Carcinogen.
- Tg-rasH2_mouse wikiPageWikiLink Category:Immunology_mice.
- Tg-rasH2_mouse wikiPageWikiLink Central_Institute_for_Experimental_Animals.
- Tg-rasH2_mouse wikiPageWikiLink International_Life_Sciences_Institute.
- Tg-rasH2_mouse wikiPageWikiLink Oncogene.
- Tg-rasH2_mouse wikiPageWikiLinkText "Tg-rasH2 mouse".
- Tg-rasH2_mouse wikiPageUsesTemplate Template:Reflist.
- Tg-rasH2_mouse wikiPageUsesTemplate Template:See_also.
- Tg-rasH2_mouse subject Category:Immunology_mice.
- Tg-rasH2_mouse hypernym Mouse.
- Tg-rasH2_mouse type Mammal.
- Tg-rasH2_mouse type Right.
- Tg-rasH2_mouse type Thing.
- Tg-rasH2_mouse comment "A Tg-rasH2 mouse is an innovative transgenic mouse, developed in Central Institute for Experimental Animals (CIEA), carrying the three copies of human prototype c-Ha-ras oncogenes with endogenous promoter and enhancer in tandem.".
- Tg-rasH2_mouse label "Tg-rasH2 mouse".
- Tg-rasH2_mouse seeAlso Ras_subfamily.
- Tg-rasH2_mouse sameAs Q7708675.
- Tg-rasH2_mouse sameAs m.03wb6b8.
- Tg-rasH2_mouse sameAs Q7708675.
- Tg-rasH2_mouse wasDerivedFrom Tg-rasH2_mouse?oldid=687925508.
- Tg-rasH2_mouse isPrimaryTopicOf Tg-rasH2_mouse.