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- TCS-OX2-29 abstract "TCS-OX2-29 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX2, with an IC50 of 40nM and selectivity of around 250x for OX2 over OX1 receptors. Orexin antagonists are expected to be useful for the treatment of insomnia, with subtype-selective antagonists such as TCS-OX2-29 potentially offering more specificity of action compared to non-selective orexin antagonists like almorexant.".
- TCS-OX2-29 casNumber "372523-75-6".
- TCS-OX2-29 iupacName "(2S)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-2-(pyridin-4-ylmethylamino)butan-1-one".
- TCS-OX2-29 pubchem "10408514".
- TCS-OX2-29 thumbnail TCS-OX2-29.svg?width=300.
- TCS-OX2-29 wikiPageID "22229405".
- TCS-OX2-29 wikiPageLength "2010".
- TCS-OX2-29 wikiPageOutDegree "12".
- TCS-OX2-29 wikiPageRevisionID "694325951".
- TCS-OX2-29 wikiPageWikiLink Almorexant.
- TCS-OX2-29 wikiPageWikiLink Category:Amides.
- TCS-OX2-29 wikiPageWikiLink Category:Orexin_antagonists.
- TCS-OX2-29 wikiPageWikiLink Category:Phenol_ethers.
- TCS-OX2-29 wikiPageWikiLink Category:Pyridines.
- TCS-OX2-29 wikiPageWikiLink Category:Sedatives.
- TCS-OX2-29 wikiPageWikiLink Category:Tetrahydroisoquinolines.
- TCS-OX2-29 wikiPageWikiLink Hypocretin_(orexin)_receptor_1.
- TCS-OX2-29 wikiPageWikiLink Hypocretin_(orexin)_receptor_2.
- TCS-OX2-29 wikiPageWikiLink Insomnia.
- TCS-OX2-29 wikiPageWikiLink Orexin_antagonist.
- TCS-OX2-29 wikiPageWikiLink Orexin_receptor.
- TCS-OX2-29 wikiPageWikiLinkText "TCS-OX2-29".
- TCS-OX2-29 c "23".
- TCS-OX2-29 casNumber "372523".
- TCS-OX2-29 h "31".
- TCS-OX2-29 iupacName "-1".
- TCS-OX2-29 iupharLigand "4038".
- TCS-OX2-29 molecularWeight "397.509".
- TCS-OX2-29 n "3".
- TCS-OX2-29 o "3".
- TCS-OX2-29 pubchem "10408514".
- TCS-OX2-29 smiles "c3cnccc3CNCCNCCc2cc1OC".
- TCS-OX2-29 verifiedrevid "398756641".
- TCS-OX2-29 width "240".
- TCS-OX2-29 wikiPageUsesTemplate Template:Drugbox.
- TCS-OX2-29 wikiPageUsesTemplate Template:Hypnotics_and_sedatives.
- TCS-OX2-29 wikiPageUsesTemplate Template:Neuropeptide_agonists_and_antagonists.
- TCS-OX2-29 wikiPageUsesTemplate Template:Sedative-stub.
- TCS-OX2-29 subject Category:Amides.
- TCS-OX2-29 subject Category:Orexin_antagonists.
- TCS-OX2-29 subject Category:Phenol_ethers.
- TCS-OX2-29 subject Category:Pyridines.
- TCS-OX2-29 subject Category:Sedatives.
- TCS-OX2-29 subject Category:Tetrahydroisoquinolines.
- TCS-OX2-29 hypernym Antagonist.
- TCS-OX2-29 type ChemicalSubstance.
- TCS-OX2-29 type Drug.
- TCS-OX2-29 type Group.
- TCS-OX2-29 type Agonist.
- TCS-OX2-29 type Amide.
- TCS-OX2-29 type Antagonist.
- TCS-OX2-29 type Chemical.
- TCS-OX2-29 type Drug.
- TCS-OX2-29 type Ether.
- TCS-OX2-29 type Group.
- TCS-OX2-29 type Heterocycle.
- TCS-OX2-29 type Redirect.
- TCS-OX2-29 type ChemicalObject.
- TCS-OX2-29 type Thing.
- TCS-OX2-29 type Q8386.
- TCS-OX2-29 comment "TCS-OX2-29 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX2, with an IC50 of 40nM and selectivity of around 250x for OX2 over OX1 receptors. Orexin antagonists are expected to be useful for the treatment of insomnia, with subtype-selective antagonists such as TCS-OX2-29 potentially offering more specificity of action compared to non-selective orexin antagonists like almorexant.".
- TCS-OX2-29 label "TCS-OX2-29".
- TCS-OX2-29 sameAs Q12747053.
- TCS-OX2-29 sameAs m.05q890b.
- TCS-OX2-29 sameAs TCS-OX2-29.
- TCS-OX2-29 sameAs TCS-OX2-29.
- TCS-OX2-29 sameAs Q12747053.
- TCS-OX2-29 wasDerivedFrom TCS-OX2-29?oldid=694325951.
- TCS-OX2-29 depiction TCS-OX2-29.svg.
- TCS-OX2-29 isPrimaryTopicOf TCS-OX2-29.