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- Substrate_channeling abstract "Substrate channeling is the passing of the intermediary metabolic product of one enzyme directly to another enzyme or active site without its release into solution. When several consecutive enzymes of a metabolic pathway channel substrates between themselves, this is called a metabolon. Channeling can make a metabolic pathway more rapid and efficient than it would be if the enzymes were randomly distributed in the cytosol, or prevent the release of unstable intermediates. It can also protect an intermediate from being consumed by competing reactions catalyzed by other enzymes.Channeling can occur in several ways. One possibility, which occurs in the pyruvate dehydrogenase complex, is by a substrate being attached to a flexible arm that moves between several active sites. Another possibility is by two active sites being connected by a tunnel through the protein and the substrate moving through the tunnel; this is seen in tryptophan synthase. A third possibility is by a charged region on the surface of the enzyme acting as a pathway or \"electrostatic highway\" to guide a substrate that has the opposite charge from one active site to another. This is seen in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase. The channeling of aminoacyl-tRNA for protein synthesis in vivo has been also reported.A presence of channel in enzyme structure is rather common feature as more than 68% of enzymes have active site access channels.".
- Substrate_channeling wikiPageID "19446142".
- Substrate_channeling wikiPageLength "3046".
- Substrate_channeling wikiPageOutDegree "13".
- Substrate_channeling wikiPageRevisionID "634845975".
- Substrate_channeling wikiPageWikiLink Active_site.
- Substrate_channeling wikiPageWikiLink Category:Enzyme_kinetics.
- Substrate_channeling wikiPageWikiLink Cytosol.
- Substrate_channeling wikiPageWikiLink Dihydrofolate_reductase.
- Substrate_channeling wikiPageWikiLink Enzyme.
- Substrate_channeling wikiPageWikiLink Enzyme_assay.
- Substrate_channeling wikiPageWikiLink Enzyme_catalysis.
- Substrate_channeling wikiPageWikiLink Enzyme_kinetics.
- Substrate_channeling wikiPageWikiLink Metabolic_pathway.
- Substrate_channeling wikiPageWikiLink Metabolon.
- Substrate_channeling wikiPageWikiLink Pyruvate_dehydrogenase_complex.
- Substrate_channeling wikiPageWikiLink Thymidylate_synthase.
- Substrate_channeling wikiPageWikiLink Tryptophan_synthase.
- Substrate_channeling wikiPageWikiLinkText "(channelling)".
- Substrate_channeling wikiPageWikiLinkText "Substrate channeling".
- Substrate_channeling wikiPageWikiLinkText "Substrate_channeling".
- Substrate_channeling wikiPageWikiLinkText "substrate channeling".
- Substrate_channeling wikiPageWikiLinkText "substrate tunneling".
- Substrate_channeling wikiPageUsesTemplate Template:Enzyme-stub.
- Substrate_channeling wikiPageUsesTemplate Template:Reflist.
- Substrate_channeling subject Category:Enzyme_kinetics.
- Substrate_channeling hypernym Passing.
- Substrate_channeling comment "Substrate channeling is the passing of the intermediary metabolic product of one enzyme directly to another enzyme or active site without its release into solution. When several consecutive enzymes of a metabolic pathway channel substrates between themselves, this is called a metabolon. Channeling can make a metabolic pathway more rapid and efficient than it would be if the enzymes were randomly distributed in the cytosol, or prevent the release of unstable intermediates.".
- Substrate_channeling label "Substrate channeling".
- Substrate_channeling sameAs Q7632168.
- Substrate_channeling sameAs Canalización_de_sustratos.
- Substrate_channeling sameAs m.04mzlkv.
- Substrate_channeling sameAs Q7632168.
- Substrate_channeling wasDerivedFrom Substrate_channeling?oldid=634845975.
- Substrate_channeling isPrimaryTopicOf Substrate_channeling.