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- Squalamine abstract "Squalamine /ˈskweɪləmiːn/ is an aminosterol compound with potent broad spectrum antimicrobial activity discovered in the tissues of the dogfish shark (Squalus acanthias) by a team led by Michael Zasloff. Dr. Zasloff searched the tissues of the dogfish for compounds that might help explain the hardiness of this animal to infection, despite its \"primitive\" immune system. Using techniques that Zasloff's team had developed to isolate and identify antimicrobial peptides from animal tissues, the team extracted and characterized a novel bile acid-like compound containing a polyamine never before seen in nature. The compound was called \"squalamine\", based on its source (Squalus acanthias) and its chemical structure (a sterol linked to a polyamine). Further analyses of larger quantities of dogfish liver extracts revealed squalamine to be the most abundant member of a larger aminosterol family comprising at least 12 related compounds. One of these, \"MSI-1436\" or trodusquemine, although structurally similar to squalamine (it carries a spermine rather than a spermidine) and also quite potent as an anti-infective, exhibits a profoundly different pharmacology in vertebrates, causing weight loss and adipose tissue mobilization. Squalamine is sometimes confused with the similar sounding squalene, an unrelated compound also found in shark liver.".
- Squalamine iupacName "(1S,2S,5S,7R,9R,10R,11S,14R,15R)-N-{3-[(4- aminobutyl)amino]propyl}-9-hydroxy-2,15-dimethyl- 14-[(2R,5R)-6-methyl-5-(sulfooxy)heptan-2- yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5- aminium".
- Squalamine thumbnail Squalamine.png?width=300.
- Squalamine wikiPageID "22213930".
- Squalamine wikiPageLength "11377".
- Squalamine wikiPageOutDegree "19".
- Squalamine wikiPageRevisionID "706658495".
- Squalamine wikiPageWikiLink Aminosterol.
- Squalamine wikiPageWikiLink Bile_acid.
- Squalamine wikiPageWikiLink Category:Angiogenesis_inhibitors.
- Squalamine wikiPageWikiLink Category:Polyamines.
- Squalamine wikiPageWikiLink Category:Steroids.
- Squalamine wikiPageWikiLink Clinical_trial.
- Squalamine wikiPageWikiLink Food_and_Drug_Administration.
- Squalamine wikiPageWikiLink Lamprey.
- Squalamine wikiPageWikiLink Lung_cancer.
- Squalamine wikiPageWikiLink Macular_degeneration.
- Squalamine wikiPageWikiLink Michael_Zasloff.
- Squalamine wikiPageWikiLink Pharmacokinetics.
- Squalamine wikiPageWikiLink Polyamine.
- Squalamine wikiPageWikiLink Spermidine.
- Squalamine wikiPageWikiLink Spermine.
- Squalamine wikiPageWikiLink Squalene.
- Squalamine wikiPageWikiLink Squalidae.
- Squalamine wikiPageWikiLink Sterol.
- Squalamine wikiPageWikiLinkText "Squalamine".
- Squalamine wikiPageWikiLinkText "squalamine".
- Squalamine imagefile "Squalamine.png".
- Squalamine imagesize "300".
- Squalamine iupacname "-N-{3-[amino]propyl}-9-hydroxy-2,15-dimethyl- 14-[-6-methyl-5-heptan-2- yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5- aminium".
- Squalamine wikiPageUsesTemplate Template:Chembox.
- Squalamine wikiPageUsesTemplate Template:Chembox_Hazards.
- Squalamine wikiPageUsesTemplate Template:Chembox_Identifiers.
- Squalamine wikiPageUsesTemplate Template:Chembox_Properties.
- Squalamine wikiPageUsesTemplate Template:Expert-subject.
- Squalamine wikiPageUsesTemplate Template:Fdacite.
- Squalamine wikiPageUsesTemplate Template:IPAc-en.
- Squalamine wikiPageUsesTemplate Template:Reflist.
- Squalamine subject Category:Angiogenesis_inhibitors.
- Squalamine subject Category:Polyamines.
- Squalamine subject Category:Steroids.
- Squalamine hypernym Compound.
- Squalamine type ChemicalCompound.
- Squalamine type ChemicalSubstance.
- Squalamine type Drug.
- Squalamine type Lipid.
- Squalamine type Chemical.
- Squalamine type Drug.
- Squalamine type Inhibitor.
- Squalamine type Lipid.
- Squalamine type Steroid.
- Squalamine type Terpene.
- Squalamine type ChemicalObject.
- Squalamine type Thing.
- Squalamine type Q11173.
- Squalamine comment "Squalamine /ˈskweɪləmiːn/ is an aminosterol compound with potent broad spectrum antimicrobial activity discovered in the tissues of the dogfish shark (Squalus acanthias) by a team led by Michael Zasloff. Dr. Zasloff searched the tissues of the dogfish for compounds that might help explain the hardiness of this animal to infection, despite its \"primitive\" immune system.".
- Squalamine label "Squalamine".
- Squalamine sameAs Q15427852.
- Squalamine sameAs m.05q5yc4.
- Squalamine sameAs Skvalamin.
- Squalamine sameAs Skvalamin.
- Squalamine sameAs Q15427852.
- Squalamine wasDerivedFrom Squalamine?oldid=706658495.
- Squalamine depiction Squalamine.png.
- Squalamine isPrimaryTopicOf Squalamine.
