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- Smokers_melanosis abstract "Smoker's melanosis is seen with the naked eye as a brown to black pigmentation of the oral tissue i.e. the gums, cheeks or palate as well as in larynx. It is most often seen in the lower labial gingiva of tobacco users. Most easily it is found in Caucasians, due to their lack of a genetically caused melanin pigmentation. However, it is also frequently reported from countries with genetically melanin-pigmented inhabitants and besides cigarette- and pipe smokers also in chutta, bidi users and reverse smokers (see \"Incidence\").The brown to black colour is melanin. In skin, melanin prevents harmful UV-light to reach deeper, sensible parts of the tissue. If UV-light penetrates deep, some of the toxic substances due to the UV-light damage to the cells, are bound to melanin in the epithelial cells and travel with the ageing cells to the skin surface, where they are expelled from the tissue surface. In this way the melanocytes and kerationocytes together protect the tissue with melanin serving as a toxic defence- and cleaning agent.In the oral mucosa, where the ageing epithelial cells move faster to the surface compared to skin, a similar defence-mechanism seems to be present, but here acting to clean the mucosa from different toxic chemicals entering the mouth. Besides chemicals in tobacco also antimalaria-drugs cause an oral pigmentation. Smoker's melanosis is like the genetic melanin pigmentations a defence-system in action.The microscope shows smoker's melanosis to be characterized by a melanin hyperpigmentation of the lower part of the oral epithelium, similar to sun-tanned skin. The hyperpigmentation consists of melanin granules which have the shape and colour of \"coffea beans\". They are produced by the dendritic, octopus-like melanocytes, seen between the epithelial cells situated closest to the epithelium/connective tissue border.In tobacco-users the melanocytes are stimulated to produce melanin granules and to distribute them out to the surrounding epithelial cells for further transport to the mucosal surface, like the mechanism in melanin-pigmented skin.Small amounts of melanin-like granules together with other electrone-dense particles can also be seen within large melanosome complexes in the underlying connective tissue. If the granules derive from the epithelium, a phenomenon known as melanin incontinence, is not known. In Caucasians these granules are not expected to influence on the clinically observed degree of smoker's melanosis.".
- Smokers_melanosis thumbnail Smoker´s_melanosis,_situated_in_the_attached_upper_and_lower_gum.jpg?width=300.
- Smokers_melanosis wikiPageID "13590484".
- Smokers_melanosis wikiPageID "13603565".
- Smokers_melanosis wikiPageLength "56".
- Smokers_melanosis wikiPageLength "9947".
- Smokers_melanosis wikiPageOutDegree "1".
- Smokers_melanosis wikiPageOutDegree "18".
- Smokers_melanosis wikiPageRedirects Smokers_melanosis.
- Smokers_melanosis wikiPageRevisionID "346067259".
- Smokers_melanosis wikiPageRevisionID "676338577".
- Smokers_melanosis wikiPageWikiLink Bidi.
- Smokers_melanosis wikiPageWikiLink Biopsy.
- Smokers_melanosis wikiPageWikiLink Category:Oral_mucosal_pathology.
- Smokers_melanosis wikiPageWikiLink Category:Smoking.
- Smokers_melanosis wikiPageWikiLink File:Discoloration_of_skin_on_finger_holding_cigarette.jpg.
- Smokers_melanosis wikiPageWikiLink File:Melanocytes_with_dendrites._Smoker´s_melanosis.jpg.
- Smokers_melanosis wikiPageWikiLink File:Melanosomes_in_the_most_basal_part_of_gingival_epithelium.jpg.
- Smokers_melanosis wikiPageWikiLink File:Smoker´s_melanosis,_situated_in_the_attached_upper_and_lower_gum.jpg.
- Smokers_melanosis wikiPageWikiLink Melanin_incontinence.
- Smokers_melanosis wikiPageWikiLink Melanosis_coli.
- Smokers_melanosis wikiPageWikiLink Nicotine.
- Smokers_melanosis wikiPageWikiLink Peutz–Jeghers_syndrome.
- Smokers_melanosis wikiPageWikiLink Samma_(tribe).
- Smokers_melanosis wikiPageWikiLink Smokeless_tobacco_keratosis.
- Smokers_melanosis wikiPageWikiLink Smokers_melanosis.
- Smokers_melanosis wikiPageWikiLink Stomatitis_nicotina.
- Smokers_melanosis wikiPageWikiLink Sweden.
- Smokers_melanosis wikiPageWikiLink Tobacco.
- Smokers_melanosis wikiPageWikiLink File:Melanocyte_with_melanin_in_dendrite_to_the_left.jpg.
- Smokers_melanosis wikiPageWikiLinkText "Smoker's melanosis".
- Smokers_melanosis wikiPageWikiLinkText "smoker's melanosis".
- Smokers_melanosis wikiPageUsesTemplate Template:Oral_pathology.
- Smokers_melanosis wikiPageUsesTemplate Template:R_from_modification.
- Smokers_melanosis wikiPageUsesTemplate Template:Reflist.
- Smokers_melanosis wikiPageUsesTemplate Template:Smoking_nav.
- Smokers_melanosis subject Category:Oral_mucosal_pathology.
- Smokers_melanosis subject Category:Smoking.
- Smokers_melanosis type Redirect.
- Smokers_melanosis comment "Smoker's melanosis is seen with the naked eye as a brown to black pigmentation of the oral tissue i.e. the gums, cheeks or palate as well as in larynx. It is most often seen in the lower labial gingiva of tobacco users. Most easily it is found in Caucasians, due to their lack of a genetically caused melanin pigmentation.".
- Smokers_melanosis label "Smoker's melanosis".
- Smokers_melanosis label "Smokers melanosis".
- Smokers_melanosis sameAs Q7545936.
- Smokers_melanosis sameAs m.03cblf2.
- Smokers_melanosis sameAs Q7545936.
- Smokers_melanosis wasDerivedFrom Smokers_melanosis?oldid=346067259.
- Smokers_melanosis wasDerivedFrom Smokers_melanosis?oldid=676338577.
- Smokers_melanosis depiction Smoker´s_melanosis,_situated_in_the_attached_upper_and_lower_gum.jpg.
- Smokers_melanosis isPrimaryTopicOf Smokers_melanosis.