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- Single-chain_variable_fragment abstract "A single-chain variable fragment (scFv) is not actually a fragment of an antibody, but instead is a fusion protein of the variable regions of the heavy (VH) and light chains (VL) of immunoglobulins, connected with a short linker peptide of ten to about 25 amino acids. The linker is usually rich in glycine for flexibility, as well as serine or threonine for solubility, and can either connect the N-terminus of the VH with the C-terminus of the VL, or vice versa.This protein retains the specificity of the original immunoglobulin, despite removal of the constant regions and the introduction of the linker. The image to the right shows how this modification usually leaves the specificity unaltered.These molecules were created to facilitate phage display, where it is highly convenient to express the antigen-binding domain as a single peptide. As an alternative, scFv can be created directly from subcloned heavy and light chains derived from a hybridoma. ScFvs have many uses, e.g., flow cytometry, immunohistochemistry, and as antigen-binding domains of artificial T cell receptors.Unlike monoclonal antibodies, which are often produced in mammalian cell cultures, scFvs are more often produced in bacteria cell cultures such as E. coli.".
- Single-chain_variable_fragment thumbnail ScFv-rotation.gif?width=300.
- Single-chain_variable_fragment wikiPageID "1624274".
- Single-chain_variable_fragment wikiPageLength "9302".
- Single-chain_variable_fragment wikiPageOutDegree "38".
- Single-chain_variable_fragment wikiPageRevisionID "704778296".
- Single-chain_variable_fragment wikiPageWikiLink Amino_acid.
- Single-chain_variable_fragment wikiPageWikiLink Antibody.
- Single-chain_variable_fragment wikiPageWikiLink Bi-specific_T-cell_engager.
- Single-chain_variable_fragment wikiPageWikiLink Bispecific_monoclonal_antibody.
- Single-chain_variable_fragment wikiPageWikiLink Breast_cancer.
- Single-chain_variable_fragment wikiPageWikiLink C-terminus.
- Single-chain_variable_fragment wikiPageWikiLink Cardiac_surgery.
- Single-chain_variable_fragment wikiPageWikiLink Category:Monoclonal_antibodies.
- Single-chain_variable_fragment wikiPageWikiLink Chimeric_antigen_receptor.
- Single-chain_variable_fragment wikiPageWikiLink Complement_component_5.
- Single-chain_variable_fragment wikiPageWikiLink Complement_system.
- Single-chain_variable_fragment wikiPageWikiLink Dissociation_constant.
- Single-chain_variable_fragment wikiPageWikiLink Escherichia_coli.
- Single-chain_variable_fragment wikiPageWikiLink Flow_cytometry.
- Single-chain_variable_fragment wikiPageWikiLink Fragment_antigen-binding.
- Single-chain_variable_fragment wikiPageWikiLink Fragment_crystallizable_region.
- Single-chain_variable_fragment wikiPageWikiLink Fusion_protein.
- Single-chain_variable_fragment wikiPageWikiLink Glycine.
- Single-chain_variable_fragment wikiPageWikiLink neu.
- Single-chain_variable_fragment wikiPageWikiLink Hybridoma_technology.
- Single-chain_variable_fragment wikiPageWikiLink Immunoglobulin_heavy_chain.
- Single-chain_variable_fragment wikiPageWikiLink Immunoglobulin_light_chain.
- Single-chain_variable_fragment wikiPageWikiLink Immunohistochemistry.
- Single-chain_variable_fragment wikiPageWikiLink Ligand_(biochemistry).
- Single-chain_variable_fragment wikiPageWikiLink Monoclonal_antibody.
- Single-chain_variable_fragment wikiPageWikiLink N-terminus.
- Single-chain_variable_fragment wikiPageWikiLink Peptide.
- Single-chain_variable_fragment wikiPageWikiLink Pexelizumab.
- Single-chain_variable_fragment wikiPageWikiLink Phage_display.
- Single-chain_variable_fragment wikiPageWikiLink Protein_A.
- Single-chain_variable_fragment wikiPageWikiLink Protein_G.
- Single-chain_variable_fragment wikiPageWikiLink Protein_L.
- Single-chain_variable_fragment wikiPageWikiLink Serine.
- Single-chain_variable_fragment wikiPageWikiLink Subcloning.
- Single-chain_variable_fragment wikiPageWikiLink Threonine.
- Single-chain_variable_fragment wikiPageWikiLink File:Polyvalent_single-chain_variable_fragments.svg.
- Single-chain_variable_fragment wikiPageWikiLink File:ScFv-rotation.gif.
- Single-chain_variable_fragment wikiPageWikiLink File:Single_chain_variable_fragment.svg.
- Single-chain_variable_fragment wikiPageWikiLinkText "Single-chain variable fragment".
- Single-chain_variable_fragment wikiPageWikiLinkText "Single-chain variable fragment#Bivalent and trivalent scFvs".
- Single-chain_variable_fragment wikiPageWikiLinkText "bivalent and trivalent single-chain variable fragments".
- Single-chain_variable_fragment wikiPageWikiLinkText "scFv".
- Single-chain_variable_fragment wikiPageWikiLinkText "scFvs".
- Single-chain_variable_fragment wikiPageWikiLinkText "single-chain variable fragment".
- Single-chain_variable_fragment wikiPageUsesTemplate Template:Engineered_antibodies.
- Single-chain_variable_fragment wikiPageUsesTemplate Template:Reflist.
- Single-chain_variable_fragment subject Category:Monoclonal_antibodies.
- Single-chain_variable_fragment hypernym Protein.
- Single-chain_variable_fragment type Protein.
- Single-chain_variable_fragment type Antibody.
- Single-chain_variable_fragment type Redirect.
- Single-chain_variable_fragment comment "A single-chain variable fragment (scFv) is not actually a fragment of an antibody, but instead is a fusion protein of the variable regions of the heavy (VH) and light chains (VL) of immunoglobulins, connected with a short linker peptide of ten to about 25 amino acids.".
- Single-chain_variable_fragment label "Single-chain variable fragment".
- Single-chain_variable_fragment sameAs Q290671.
- Single-chain_variable_fragment sameAs ScFv-Fragment.
- Single-chain_variable_fragment sameAs Anticuerpo_de_cadena_sencilla.
- Single-chain_variable_fragment sameAs m.05hkgx.
- Single-chain_variable_fragment sameAs Q290671.
- Single-chain_variable_fragment wasDerivedFrom Single-chain_variable_fragment?oldid=704778296.
- Single-chain_variable_fragment depiction ScFv-rotation.gif.
- Single-chain_variable_fragment isPrimaryTopicOf Single-chain_variable_fragment.
