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- Senescence-associated_beta-galactosidase abstract "Senescence-associated beta-galactosidase (SA-β-gal or SABG) is a hypothetical hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides only in senescent cells.Its existence was proposed in 1995 by Dimri et al. following the observation that when beta-galactosidase assays were carried out at pH 6.0, only cells in senescence state develop staining. They proposed a cytochemical assay based on production of a blue-dyed precipitate that results from the cleavage of the chromogenic substrate X-Gal. Since then, even more specific quantitative assays were developed for its detection at pH 6.0.Today this phenomenon is explained by the overexpression and accumulation of the endogenous lysosomal beta-galactosidase specifically in senescent cells. Its expression is not required for senescence. However, it remains as the most widely used biomarker for senescent and aging cells, because it is easy to detect and reliable both in situ and in vitro.".
- Senescence-associated_beta-galactosidase arm "p".
- Senescence-associated_beta-galactosidase band "22.3".
- Senescence-associated_beta-galactosidase chromosome "3".
- Senescence-associated_beta-galactosidase ecNumber "3.2.1.23".
- Senescence-associated_beta-galactosidase entrezgene "2720".
- Senescence-associated_beta-galactosidase hgncid "4298".
- Senescence-associated_beta-galactosidase omim "611458".
- Senescence-associated_beta-galactosidase refseq "NM_000404".
- Senescence-associated_beta-galactosidase symbol "GLB1".
- Senescence-associated_beta-galactosidase symbol "SA-β-Gal".
- Senescence-associated_beta-galactosidase uniprot "P16278".
- Senescence-associated_beta-galactosidase wikiPageExternalLink 8058-2-l.jpg.
- Senescence-associated_beta-galactosidase wikiPageExternalLink 8058-2-l.jpg.
- Senescence-associated_beta-galactosidase wikiPageID "22896390".
- Senescence-associated_beta-galactosidase wikiPageLength "4534".
- Senescence-associated_beta-galactosidase wikiPageOutDegree "17".
- Senescence-associated_beta-galactosidase wikiPageRevisionID "706678145".
- Senescence-associated_beta-galactosidase wikiPageWikiLink Beta-galactosidase.
- Senescence-associated_beta-galactosidase wikiPageWikiLink Catalysis.
- Senescence-associated_beta-galactosidase wikiPageWikiLink Category:Ageing.
- Senescence-associated_beta-galactosidase wikiPageWikiLink Category:Aging-related_enzymes.
- Senescence-associated_beta-galactosidase wikiPageWikiLink Category:Gerontology.
- Senescence-associated_beta-galactosidase wikiPageWikiLink Category:Hydrolases.
- Senescence-associated_beta-galactosidase wikiPageWikiLink Enzyme.
- Senescence-associated_beta-galactosidase wikiPageWikiLink GLB1.
- Senescence-associated_beta-galactosidase wikiPageWikiLink Galactoside.
- Senescence-associated_beta-galactosidase wikiPageWikiLink Hydrolase.
- Senescence-associated_beta-galactosidase wikiPageWikiLink Hydrolysis.
- Senescence-associated_beta-galactosidase wikiPageWikiLink Lysosome.
- Senescence-associated_beta-galactosidase wikiPageWikiLink Monosaccharide.
- Senescence-associated_beta-galactosidase wikiPageWikiLink Senescence.
- Senescence-associated_beta-galactosidase wikiPageWikiLinkText "Senescence-associated beta-galactosidase".
- Senescence-associated_beta-galactosidase wikiPageWikiLinkText "senescence-associated β-galactosidase".
- Senescence-associated_beta-galactosidase altsymbols "SA-β-Gal".
- Senescence-associated_beta-galactosidase arm "p".
- Senescence-associated_beta-galactosidase band "22.3".
- Senescence-associated_beta-galactosidase chromosome "3".
- Senescence-associated_beta-galactosidase ecnumber "3.2".
- Senescence-associated_beta-galactosidase entrezgene "2720".
- Senescence-associated_beta-galactosidase hgncid "4298".
- Senescence-associated_beta-galactosidase name GLB1.
- Senescence-associated_beta-galactosidase omim "611458".
- Senescence-associated_beta-galactosidase refseq "NM_000404".
- Senescence-associated_beta-galactosidase symbol GLB1.
- Senescence-associated_beta-galactosidase uniprot "P16278".
- Senescence-associated_beta-galactosidase wikiPageUsesTemplate Template:Cite_journal.
- Senescence-associated_beta-galactosidase wikiPageUsesTemplate Template:Cite_web.
- Senescence-associated_beta-galactosidase wikiPageUsesTemplate Template:Enzyme-stub.
- Senescence-associated_beta-galactosidase wikiPageUsesTemplate Template:Protein.
- Senescence-associated_beta-galactosidase wikiPageUsesTemplate Template:Reflist.
- Senescence-associated_beta-galactosidase subject Category:Ageing.
- Senescence-associated_beta-galactosidase subject Category:Aging-related_enzymes.
- Senescence-associated_beta-galactosidase subject Category:Gerontology.
- Senescence-associated_beta-galactosidase subject Category:Hydrolases.
- Senescence-associated_beta-galactosidase hypernym Enzyme.
- Senescence-associated_beta-galactosidase type Biomolecule.
- Senescence-associated_beta-galactosidase type Protein.
- Senescence-associated_beta-galactosidase type Specialty.
- Senescence-associated_beta-galactosidase type Thing.
- Senescence-associated_beta-galactosidase type Q206229.
- Senescence-associated_beta-galactosidase type Q8054.
- Senescence-associated_beta-galactosidase comment "Senescence-associated beta-galactosidase (SA-β-gal or SABG) is a hypothetical hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides only in senescent cells.Its existence was proposed in 1995 by Dimri et al. following the observation that when beta-galactosidase assays were carried out at pH 6.0, only cells in senescence state develop staining.".
- Senescence-associated_beta-galactosidase label "Senescence-associated beta-galactosidase".
- Senescence-associated_beta-galactosidase sameAs Q15997123.
- Senescence-associated_beta-galactosidase sameAs m.0641vj3.
- Senescence-associated_beta-galactosidase sameAs Q15997123.
- Senescence-associated_beta-galactosidase wasDerivedFrom Senescence-associated_beta-galactosidase?oldid=706678145.
- Senescence-associated_beta-galactosidase isPrimaryTopicOf Senescence-associated_beta-galactosidase.
- Senescence-associated_beta-galactosidase name "galactosidase, beta 1".