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- Sea_anemone_cytotoxic_protein abstract "In molecular biology, the sea anemone cytotoxic proteins are lethal pore-forming peptides and proteins, known collectively as cytolysins or actinoporins. There are several different groups of cytolysins based on their structure and function. This entry represents the most numerous group, the 20kDa highly basic peptides. These cytolysins form cation-selective pores in sphingomyelin-containing membranes. Examples include equinatoxins (from Actinia equina), sticholysins (from Stichodactyla helianthus), magnificalysins (from Heteractis magnifica), and tenebrosins (from Actinia tenebrosa), which exhibit pore-forming, haemolytic, cytotoxic, and heart stimulatory activities.Cytolysins adopt a stable soluble structure, which undergoes a conformational change when brought in contact with a membrane, leading to an active, membrane-bound form that inserts spontaneously into the membrane. They often oligomerise on the membrane surface, before puncturing the lipid bilayers, causing the cell to lyse. The 20kDa sea anemone cytolysins require a phosphocholine lipid headgroup for binding, however sphingomyelin is required for the toxin to promote membrane permeability. The crystal structures of equinatoxin II and sticholysin II both revealed a compact beta-sandwich consisting of ten strands in two sheets flanked on each side by two short alpha-helices, which is a similar topology to osmotin. It is believed that the beta sandwich structure attaches to the membrane, while a three-turn alpha helix lying on the surface of the beta sheet may be involved in membrane pore formation, possibly by the penetration of the membrane by the helix.".
- Sea_anemone_cytotoxic_protein symbol "Anemone_cytotox".
- Sea_anemone_cytotoxic_protein thumbnail PDB_1o72_EBI.jpg?width=300.
- Sea_anemone_cytotoxic_protein wikiPageID "32113060".
- Sea_anemone_cytotoxic_protein wikiPageLength "3810".
- Sea_anemone_cytotoxic_protein wikiPageOutDegree "22".
- Sea_anemone_cytotoxic_protein wikiPageRevisionID "671041665".
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Alpha_helix.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Beta_sheet.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Biological_membrane.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Biomolecular_structure.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Category:Protein_families.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Cell_(biology).
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Cell_membrane.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Conformational_change.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Crystal_structure.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Heart.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Helix.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Lipid.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Lysis.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Peptide.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Solubility.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Sphingomyelin.
- Sea_anemone_cytotoxic_protein wikiPageWikiLink Toxin.
- Sea_anemone_cytotoxic_protein wikiPageWikiLinkText "Sea anemone cytotoxic protein".
- Sea_anemone_cytotoxic_protein caption "crystal structure of the water-soluble state of the pore-forming cytolysin sticholysin ii complexed with phosphorylcholine".
- Sea_anemone_cytotoxic_protein interpro "IPR009104".
- Sea_anemone_cytotoxic_protein name "Anemone_cytotox".
- Sea_anemone_cytotoxic_protein opmFamily "103".
- Sea_anemone_cytotoxic_protein opmProtein "1".
- Sea_anemone_cytotoxic_protein pfam "PF06369".
- Sea_anemone_cytotoxic_protein scop "1".
- Sea_anemone_cytotoxic_protein symbol "Anemone_cytotox".
- Sea_anemone_cytotoxic_protein tcdb "1".
- Sea_anemone_cytotoxic_protein wikiPageUsesTemplate Template:Infobox_protein_family.
- Sea_anemone_cytotoxic_protein wikiPageUsesTemplate Template:InterPro_content.
- Sea_anemone_cytotoxic_protein wikiPageUsesTemplate Template:Reflist.
- Sea_anemone_cytotoxic_protein subject Category:Protein_families.
- Sea_anemone_cytotoxic_protein hypernym Peptides.
- Sea_anemone_cytotoxic_protein type Biomolecule.
- Sea_anemone_cytotoxic_protein type Protein.
- Sea_anemone_cytotoxic_protein type Chemical.
- Sea_anemone_cytotoxic_protein type Thing.
- Sea_anemone_cytotoxic_protein type Q206229.
- Sea_anemone_cytotoxic_protein type Q8054.
- Sea_anemone_cytotoxic_protein comment "In molecular biology, the sea anemone cytotoxic proteins are lethal pore-forming peptides and proteins, known collectively as cytolysins or actinoporins. There are several different groups of cytolysins based on their structure and function. This entry represents the most numerous group, the 20kDa highly basic peptides. These cytolysins form cation-selective pores in sphingomyelin-containing membranes.".
- Sea_anemone_cytotoxic_protein label "Sea anemone cytotoxic protein".
- Sea_anemone_cytotoxic_protein sameAs Q7440050.
- Sea_anemone_cytotoxic_protein sameAs m.0gwyxhd.
- Sea_anemone_cytotoxic_protein sameAs Q7440050.
- Sea_anemone_cytotoxic_protein wasDerivedFrom Sea_anemone_cytotoxic_protein?oldid=671041665.
- Sea_anemone_cytotoxic_protein depiction PDB_1o72_EBI.jpg.
- Sea_anemone_cytotoxic_protein isPrimaryTopicOf Sea_anemone_cytotoxic_protein.