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- SN-38 abstract "SN-38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor); it is 1000 times more active than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold.SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1.The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excreted from the body in its SN-38 glucuronide form.SN-38 and its glucuronide are lost into the bile and feces. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan.".
- SN-38 thumbnail SN-38.svg?width=300.
- SN-38 wikiPageID "13981137".
- SN-38 wikiPageLength "2880".
- SN-38 wikiPageOutDegree "13".
- SN-38 wikiPageRevisionID "704266929".
- SN-38 wikiPageWikiLink Bone_marrow_suppression.
- SN-38 wikiPageWikiLink Camptothecin.
- SN-38 wikiPageWikiLink Carboxylesterase.
- SN-38 wikiPageWikiLink Category:Topoisomerase_inhibitors.
- SN-38 wikiPageWikiLink Diarrhea.
- SN-38 wikiPageWikiLink Glucuronidation.
- SN-38 wikiPageWikiLink Irinotecan.
- SN-38 wikiPageWikiLink Metabolite.
- SN-38 wikiPageWikiLink NK012.
- SN-38 wikiPageWikiLink Toxicity.
- SN-38 wikiPageWikiLink Type_I_topoisomerase.
- SN-38 wikiPageWikiLink UDP_glucuronosyltransferase_1_family,_polypeptide_A1.
- SN-38 wikiPageWikiLinkText "SN-38".
- SN-38 imagefile "SN-38.svg".
- SN-38 othernames "7".
- SN-38 verifiedfields "changed".
- SN-38 verifiedrevid "464385520".
- SN-38 wikiPageUsesTemplate Template:Cascite.
- SN-38 wikiPageUsesTemplate Template:Chembox.
- SN-38 wikiPageUsesTemplate Template:Chembox_Hazards.
- SN-38 wikiPageUsesTemplate Template:Chembox_Identifiers.
- SN-38 wikiPageUsesTemplate Template:Chembox_Properties.
- SN-38 wikiPageUsesTemplate Template:Chemspidercite.
- SN-38 wikiPageUsesTemplate Template:Ebicite.
- SN-38 wikiPageUsesTemplate Template:Fdacite.
- SN-38 wikiPageUsesTemplate Template:IrinotecanPathway_WP229.
- SN-38 wikiPageUsesTemplate Template:Oncology-stub.
- SN-38 wikiPageUsesTemplate Template:Reflist.
- SN-38 wikiPageUsesTemplate Template:Stdinchicite.
- SN-38 subject Category:Topoisomerase_inhibitors.
- SN-38 hypernym Metabolite.
- SN-38 type ChemicalCompound.
- SN-38 type ChemicalSubstance.
- SN-38 type Chemical.
- SN-38 type Inhibitor.
- SN-38 type Redirect.
- SN-38 type ChemicalObject.
- SN-38 type Thing.
- SN-38 type Q11173.
- SN-38 comment "SN-38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor); it is 1000 times more active than irinotecan itself.".
- SN-38 label "SN-38".
- SN-38 sameAs Q1750127.
- SN-38 sameAs اسان-۳۸.
- SN-38 sameAs SN-38.
- SN-38 sameAs m.03cq1n9.
- SN-38 sameAs SN-38.
- SN-38 sameAs SN-38.
- SN-38 sameAs Q1750127.
- SN-38 wasDerivedFrom SN-38?oldid=704266929.
- SN-38 depiction SN-38.svg.
- SN-38 isPrimaryTopicOf SN-38.