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- SC-5233 abstract "SC-5233 is a steroidal antimineralocorticoid of the spirolactone group that was developed by G. D. Searle & Company in the 1950s but was never marketed. It was the first antagonist of the mineralocorticoid receptor to have been identified and tested in humans. The drug was found to have poor oral bioavailability and potency, but it nonetheless produced a mild diuretic effect in patients with congestive heart failure. SC-8109, the 19-nor (19-demethyl) analogue, was developed and found to have improved oral bioavailability and potency, but still had relatively low potency. Spironolactone (SC-9420; Aldactone) followed and had both good oral bioavailability and potency, and was the first antimineralocorticoid to be marketed.SC-5233 is the propanoic acid lactone of 17β-hydroxyandrosterone. It is the unsubstituted parent or prototype compound of the spirolactone family of steroidal antimineralocorticoids.".
- SC-5233 atcPrefix "None".
- SC-5233 casNumber "976-70-5".
- SC-5233 iupacName "(8R,9S,10R,13S,14S,17R)-10,13-Dimethylspiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione".
- SC-5233 pubchem "101931".
- SC-5233 wikiPageID "48972042".
- SC-5233 wikiPageLength "4811".
- SC-5233 wikiPageOutDegree "25".
- SC-5233 wikiPageRevisionID "700182076".
- SC-5233 wikiPageWikiLink 17β-hydroxyandrosterone.
- SC-5233 wikiPageWikiLink Antimineralocorticoid.
- SC-5233 wikiPageWikiLink Bioavailability.
- SC-5233 wikiPageWikiLink Canrenone.
- SC-5233 wikiPageWikiLink Category:Abandoned_drugs.
- SC-5233 wikiPageWikiLink Category:Aldosterone_antagonists.
- SC-5233 wikiPageWikiLink Category:Lactones.
- SC-5233 wikiPageWikiLink Category:Spiro_compounds.
- SC-5233 wikiPageWikiLink Category:Steroids.
- SC-5233 wikiPageWikiLink Diuretic.
- SC-5233 wikiPageWikiLink G.D._Searle,_LLC.
- SC-5233 wikiPageWikiLink Heart_failure.
- SC-5233 wikiPageWikiLink Lactone.
- SC-5233 wikiPageWikiLink Mineralocorticoid_receptor.
- SC-5233 wikiPageWikiLink Oral_administration.
- SC-5233 wikiPageWikiLink Parent.
- SC-5233 wikiPageWikiLink Parent_structure.
- SC-5233 wikiPageWikiLink Potency_(pharmacology).
- SC-5233 wikiPageWikiLink Propionic_acid.
- SC-5233 wikiPageWikiLink Receptor_antagonist.
- SC-5233 wikiPageWikiLink SC-8109.
- SC-5233 wikiPageWikiLink Spirolactone.
- SC-5233 wikiPageWikiLink Spironolactone.
- SC-5233 wikiPageWikiLink Steroid.
- SC-5233 wikiPageWikiLink Structural_analog.
- SC-5233 wikiPageWikiLinkText "SC-5233".
- SC-5233 atcPrefix "None".
- SC-5233 c "22".
- SC-5233 casNumber "976".
- SC-5233 chemspiderid "92091".
- SC-5233 h "30".
- SC-5233 inchi "InChI=1S/C22H30O3/c1-20-9-5-1513-143-4-16-176-10-21187-11-2212-8-1925-22/h13,16-18H,3-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1".
- SC-5233 inchikey "UWBICEKKOYXZRG-WNHSNXHDSA-N".
- SC-5233 iupacName "-120.0".
- SC-5233 molecularWeight "342.4718".
- SC-5233 o "3".
- SC-5233 pubchem "101931".
- SC-5233 routesOfAdministration Oral_administration.
- SC-5233 smiles "CC12CCCC=C1CCC3C2CCC4C".
- SC-5233 synonyms "20".
- SC-5233 wikiPageUsesTemplate Template:Antimineralocorticoids.
- SC-5233 wikiPageUsesTemplate Template:Diuretics.
- SC-5233 wikiPageUsesTemplate Template:Drug-stub.
- SC-5233 wikiPageUsesTemplate Template:Drugbox.
- SC-5233 wikiPageUsesTemplate Template:Mineralocorticoidics.
- SC-5233 wikiPageUsesTemplate Template:Reflist.
- SC-5233 subject Category:Abandoned_drugs.
- SC-5233 subject Category:Aldosterone_antagonists.
- SC-5233 subject Category:Lactones.
- SC-5233 subject Category:Spiro_compounds.
- SC-5233 subject Category:Steroids.
- SC-5233 hypernym Antimineralocorticoid.
- SC-5233 type ChemicalSubstance.
- SC-5233 type Drug.
- SC-5233 type ChemicalObject.
- SC-5233 type Thing.
- SC-5233 type Q8386.
- SC-5233 comment "SC-5233 is a steroidal antimineralocorticoid of the spirolactone group that was developed by G. D. Searle & Company in the 1950s but was never marketed. It was the first antagonist of the mineralocorticoid receptor to have been identified and tested in humans. The drug was found to have poor oral bioavailability and potency, but it nonetheless produced a mild diuretic effect in patients with congestive heart failure.".
- SC-5233 label "SC-5233".
- SC-5233 wasDerivedFrom SC-5233?oldid=700182076.
- SC-5233 isPrimaryTopicOf SC-5233.