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- Rolipram abstract "Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It served as a prototype molecule for several companies' drug discovery and development efforts. Rolipram was discontinued after clinical trials showed that its therapeutic window was too narrow; it could not be dosed at high enough levels to be effective without causing significant gastrointestinal side effects.Rolipram has several activities that make it a continuing focus for research. The etiology of many neurodegenerative diseases involves misfolded and clumped proteins which accumulate in the brain. Cells have a mechanism to dispose of such proteins called the proteasome. However, in Alzheimer's disease and some other conditions the activity of these proteasomes is impaired leading to a buildup of toxic aggregates. Research in mice suggests that rolipram has the ability to ramp up the activity of proteasomes and reduce the burden of these aggregates. Preliminary evidence suggests that this can improve spatial memory in mice engineered to have aggregate build-up. It continues to be used in research as a well-characterized PDE4 inhibitor. It has been used in studies to understand whether PDE4 inhibition could be useful in autoimmune diseases, Alzheimer's disease, cognitive enhancement, spinal cord injury, and respiratory diseases like asthma and COPD.".
- Rolipram atcPrefix "none".
- Rolipram bioavailability "75.0".
- Rolipram casNumber "61413-54-5".
- Rolipram chEBI "104872".
- Rolipram drugbank "DB04149".
- Rolipram fdaUniiCode "K676NL63N7".
- Rolipram iupacName "(RS)-4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-one".
- Rolipram pubchem "5092".
- Rolipram thumbnail Rolipram2DACS.svg?width=300.
- Rolipram wikiPageID "7418805".
- Rolipram wikiPageLength "6043".
- Rolipram wikiPageOutDegree "15".
- Rolipram wikiPageRevisionID "704429465".
- Rolipram wikiPageWikiLink Antidepressant.
- Rolipram wikiPageWikiLink Autoimmune_disease.
- Rolipram wikiPageWikiLink CYP2C19.
- Rolipram wikiPageWikiLink CYP2C8.
- Rolipram wikiPageWikiLink CYP2C9.
- Rolipram wikiPageWikiLink CYP2D6.
- Rolipram wikiPageWikiLink Category:PDE4_inhibitors.
- Rolipram wikiPageWikiLink Category:Phenol_ethers.
- Rolipram wikiPageWikiLink Category:Pyrrolidones.
- Rolipram wikiPageWikiLink Chronic_obstructive_pulmonary_disease.
- Rolipram wikiPageWikiLink Drug_discovery.
- Rolipram wikiPageWikiLink Liver.
- Rolipram wikiPageWikiLink Phosphodiesterase-4_inhibitor.
- Rolipram wikiPageWikiLink Schering_AG.
- Rolipram wikiPageWikiLink Therapeutic_index.
- Rolipram wikiPageWikiLinkText "Rolipram".
- Rolipram wikiPageWikiLinkText "rolipram".
- Rolipram atcPrefix "none".
- Rolipram bioavailability "75.0".
- Rolipram c "16".
- Rolipram casNumber "61413".
- Rolipram chebi "104872".
- Rolipram chembl "63".
- Rolipram chemspiderid "4913".
- Rolipram drugbank "DB04149".
- Rolipram eliminationHalfLife "10800.0".
- Rolipram excretion "Urine".
- Rolipram h "21".
- Rolipram image "Rolipram3Dan2.gif".
- Rolipram iupacName "-4".
- Rolipram iupharLigand "5260".
- Rolipram legalStatus "Investigational".
- Rolipram metabolism "Hepatic via CYP2C8, CYP2C9, CYP2C19 and CYP2D6".
- Rolipram molecularWeight "275.347".
- Rolipram n "1".
- Rolipram o "3".
- Rolipram pubchem "5092".
- Rolipram smiles "COc1cccC1CNCC1".
- Rolipram stdinchi "1".
- Rolipram stdinchikey "HJORMJIFDVBMOB-UHFFFAOYSA-N".
- Rolipram unii "K676NL63N7".
- Rolipram verifiedfields "changed".
- Rolipram verifiedrevid "464383368".
- Rolipram width "150".
- Rolipram width "200".
- Rolipram wikiPageUsesTemplate Template:Cascite.
- Rolipram wikiPageUsesTemplate Template:Chemspidercite.
- Rolipram wikiPageUsesTemplate Template:Drugbankcite.
- Rolipram wikiPageUsesTemplate Template:Drugbox.
- Rolipram wikiPageUsesTemplate Template:Ebicite.
- Rolipram wikiPageUsesTemplate Template:Fdacite.
- Rolipram wikiPageUsesTemplate Template:Phosphodiesterase_inhibitors.
- Rolipram wikiPageUsesTemplate Template:Reflist.
- Rolipram wikiPageUsesTemplate Template:Rp.
- Rolipram wikiPageUsesTemplate Template:Stdinchicite.
- Rolipram subject Category:PDE4_inhibitors.
- Rolipram subject Category:Phenol_ethers.
- Rolipram subject Category:Pyrrolidones.
- Rolipram hypernym Inhibitor.
- Rolipram type ChemicalSubstance.
- Rolipram type Drug.
- Rolipram type Chemical.
- Rolipram type Drug.
- Rolipram type Ether.
- Rolipram type Inhibitor.
- Rolipram type Lactam.
- Rolipram type ChemicalObject.
- Rolipram type Thing.
- Rolipram type Q8386.
- Rolipram comment "Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It served as a prototype molecule for several companies' drug discovery and development efforts.".
- Rolipram label "Rolipram".
- Rolipram sameAs Q410285.
- Rolipram sameAs Rolipram.
- Rolipram sameAs ロリプラム.
- Rolipram sameAs m.01xm8nm.
- Rolipram sameAs Rolipram.
- Rolipram sameAs Rolipram.
- Rolipram sameAs Роліпрам.
- Rolipram sameAs Q410285.
- Rolipram wasDerivedFrom Rolipram?oldid=704429465.
- Rolipram depiction Rolipram2DACS.svg.
- Rolipram isPrimaryTopicOf Rolipram.