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- Ro4-1539 abstract "Ro4-1539 (Furethylnorlevorphanol) is an opioid analgesic drug from the morphinan series that was developed by the pharmaceutical company Hoffmann–La Roche in the 1950s. It acts as a potent μ-opioid agonist, and was found to be around 30-60x more potent than the related drug levorphanol in animal experiments. While it is notable for its high potency and therapeutic index (1100 in animal studies), being among the more potent μ-agonist found in the morphinan series of drugs (though not on the scale of acetorphine and other morphinans in the extremity of their level of potency), Ro4-1539 had no particular clinical advantages over other available opioid drugs, and was never commercially marketed.Ro4-1539 has never formally undergone clinical trials in humans, but based on its effects in animals it would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching, tachyphylaxis and respiratory depression, which could be harmful or fatal.".
- Ro4-1539 casNumber "27767-85-7".
- Ro4-1539 iupacName "17-(2-(furan-2-yl)ethyl)-3-hydroxymorphinan".
- Ro4-1539 pubchem "20834001".
- Ro4-1539 thumbnail Furethylnorlevorphanol.svg?width=300.
- Ro4-1539 wikiPageID "21277751".
- Ro4-1539 wikiPageLength "2951".
- Ro4-1539 wikiPageOutDegree "27".
- Ro4-1539 wikiPageRevisionID "698506734".
- Ro4-1539 wikiPageWikiLink 14-Cinnamoyloxycodeinone.
- Ro4-1539 wikiPageWikiLink 14-Phenylpropoxymetopon.
- Ro4-1539 wikiPageWikiLink 7-PET.
- Ro4-1539 wikiPageWikiLink Acetorphine.
- Ro4-1539 wikiPageWikiLink Analgesic.
- Ro4-1539 wikiPageWikiLink Category:Furans.
- Ro4-1539 wikiPageWikiLink Category:Hoffmann-La_Roche.
- Ro4-1539 wikiPageWikiLink Category:Morphinans.
- Ro4-1539 wikiPageWikiLink Category:Mu-opioid_agonists.
- Ro4-1539 wikiPageWikiLink Category:Opioids.
- Ro4-1539 wikiPageWikiLink Category:Phenols.
- Ro4-1539 wikiPageWikiLink Constipation.
- Ro4-1539 wikiPageWikiLink Euphoria.
- Ro4-1539 wikiPageWikiLink Hoffmann-La_Roche.
- Ro4-1539 wikiPageWikiLink Hypoventilation.
- Ro4-1539 wikiPageWikiLink Itch.
- Ro4-1539 wikiPageWikiLink Levorphanol.
- Ro4-1539 wikiPageWikiLink Morphinan.
- Ro4-1539 wikiPageWikiLink N-Phenethyl-14-ethoxymetopon.
- Ro4-1539 wikiPageWikiLink N-Phenethylnormorphine.
- Ro4-1539 wikiPageWikiLink Opioid.
- Ro4-1539 wikiPageWikiLink Phenomorphan.
- Ro4-1539 wikiPageWikiLink RAM-378.
- Ro4-1539 wikiPageWikiLink Sedation.
- Ro4-1539 wikiPageWikiLink Tachyphylaxis.
- Ro4-1539 wikiPageWikiLink Μ-opioid_receptor.
- Ro4-1539 wikiPageWikiLinkText "Ro4-1539".
- Ro4-1539 c "22".
- Ro4-1539 casNumber "27767".
- Ro4-1539 h "27".
- Ro4-1539 iupacName "17".
- Ro4-1539 molecularWeight "337.454".
- Ro4-1539 n "1".
- Ro4-1539 o "2".
- Ro4-1539 pubchem "20834001".
- Ro4-1539 smiles "C3CCCC1C35c2ccccc2CC1NCCc4ccco4".
- Ro4-1539 verifiedrevid "450105432".
- Ro4-1539 width "240".
- Ro4-1539 wikiPageUsesTemplate Template:Analgesic-stub.
- Ro4-1539 wikiPageUsesTemplate Template:Cascite.
- Ro4-1539 wikiPageUsesTemplate Template:Drugbox.
- Ro4-1539 wikiPageUsesTemplate Template:Opioidergics.
- Ro4-1539 wikiPageUsesTemplate Template:Reflist.
- Ro4-1539 subject Category:Furans.
- Ro4-1539 subject Category:Hoffmann-La_Roche.
- Ro4-1539 subject Category:Morphinans.
- Ro4-1539 subject Category:Mu-opioid_agonists.
- Ro4-1539 subject Category:Opioids.
- Ro4-1539 subject Category:Phenols.
- Ro4-1539 hypernym Drug.
- Ro4-1539 type ChemicalSubstance.
- Ro4-1539 type Company.
- Ro4-1539 type Drug.
- Ro4-1539 type Agonist.
- Ro4-1539 type Alcohol.
- Ro4-1539 type Alkaloid.
- Ro4-1539 type Analgesic.
- Ro4-1539 type Chemical.
- Ro4-1539 type Company.
- Ro4-1539 type Drug.
- Ro4-1539 type Heterocycle.
- Ro4-1539 type Opioid.
- Ro4-1539 type ChemicalObject.
- Ro4-1539 type Thing.
- Ro4-1539 type Q8386.
- Ro4-1539 comment "Ro4-1539 (Furethylnorlevorphanol) is an opioid analgesic drug from the morphinan series that was developed by the pharmaceutical company Hoffmann–La Roche in the 1950s. It acts as a potent μ-opioid agonist, and was found to be around 30-60x more potent than the related drug levorphanol in animal experiments.".
- Ro4-1539 label "Ro4-1539".
- Ro4-1539 sameAs Q7339200.
- Ro4-1539 sameAs m.05f5gqb.
- Ro4-1539 sameAs Ro4-1539.
- Ro4-1539 sameAs Ro4-1539.
- Ro4-1539 sameAs Q7339200.
- Ro4-1539 wasDerivedFrom Ro4-1539?oldid=698506734.
- Ro4-1539 depiction Furethylnorlevorphanol.svg.
- Ro4-1539 isPrimaryTopicOf Ro4-1539.