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- Retroviral_aspartyl_protease abstract "Retroviral aspartyl proteases are single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger pol or gag polyprotein. Retroviral proteases are homologous to a single domain of the two-domain eukaryotic aspartyl proteases such as pepsins, cathepsins, and renins (Pfam PF00026). Aspartic endopeptidases EC 3.4.23. of vertebrate, fungal and retroviral origin have been characterised. More recently, aspartic endopeptidases associated with the processing of bacterial type 4 prepilin and archaean preflagellin have been described.Structurally, aspartic endopeptidases are bilobal enzymes, each lobe contributing a catalytic Asp residue, with an extended active site cleft localized between the two lobes of the molecule. One lobe has probably evolved from the other through a gene duplication event in the distant past. In modern-day enzymes, although the three-dimensional structures are very similar, the amino acid sequences are more divergent, except for the catalytic site motif, which is very conserved. The presence and position of disulphide bridges are other conserved features of aspartic peptidases. All or most aspartate peptidases are endopeptidases. These enzymes have been assigned into clans (proteins which are evolutionary related), and further sub-divided into families, largely on the basis of their tertiary structure.Retroviral aspartyl protease is synthesised as part of the POL polyprotein that contains; an aspartyl protease, a reverse transcriptase, RNase H and integrase. POL polyprotein undergoes specific enzymatic cleavage to yield the mature proteins.".
- Retroviral_aspartyl_protease symbol "RVP".
- Retroviral_aspartyl_protease wikiPageID "28987451".
- Retroviral_aspartyl_protease wikiPageLength "3521".
- Retroviral_aspartyl_protease wikiPageOutDegree "22".
- Retroviral_aspartyl_protease wikiPageRevisionID "701723796".
- Retroviral_aspartyl_protease wikiPageWikiLink Aspartic_protease.
- Retroviral_aspartyl_protease wikiPageWikiLink Badnaviruse.
- Retroviral_aspartyl_protease wikiPageWikiLink Category:EC_3.4.23.
- Retroviral_aspartyl_protease wikiPageWikiLink Category:Peptidase.
- Retroviral_aspartyl_protease wikiPageWikiLink Category:Protein_domains.
- Retroviral_aspartyl_protease wikiPageWikiLink Cathepsin.
- Retroviral_aspartyl_protease wikiPageWikiLink DDI1.
- Retroviral_aspartyl_protease wikiPageWikiLink DDI2.
- Retroviral_aspartyl_protease wikiPageWikiLink DNA.
- Retroviral_aspartyl_protease wikiPageWikiLink ERVK6.
- Retroviral_aspartyl_protease wikiPageWikiLink Endopeptidase.
- Retroviral_aspartyl_protease wikiPageWikiLink Integrase.
- Retroviral_aspartyl_protease wikiPageWikiLink POL_polyprotein.
- Retroviral_aspartyl_protease wikiPageWikiLink Pepsin.
- Retroviral_aspartyl_protease wikiPageWikiLink Proteolysis.
- Retroviral_aspartyl_protease wikiPageWikiLink Renin.
- Retroviral_aspartyl_protease wikiPageWikiLink Retrotransposon.
- Retroviral_aspartyl_protease wikiPageWikiLink Retrovirus.
- Retroviral_aspartyl_protease wikiPageWikiLink Reverse_transcriptase.
- Retroviral_aspartyl_protease wikiPageWikiLink Ribonuclease_H.
- Retroviral_aspartyl_protease wikiPageWikiLinkText "Retroviral aspartyl protease".
- Retroviral_aspartyl_protease wikiPageWikiLinkText "retroviral aspartyl protease".
- Retroviral_aspartyl_protease interpro "IPR001995".
- Retroviral_aspartyl_protease name "Retroviral aspartyl protease".
- Retroviral_aspartyl_protease opmFamily "108".
- Retroviral_aspartyl_protease opmProtein "2".
- Retroviral_aspartyl_protease pfam "PF00077".
- Retroviral_aspartyl_protease prosite "PDOC00128".
- Retroviral_aspartyl_protease scop "1".
- Retroviral_aspartyl_protease symbol "RVP".
- Retroviral_aspartyl_protease wikiPageUsesTemplate Template:Aspartic_acid_proteases.
- Retroviral_aspartyl_protease wikiPageUsesTemplate Template:EC_number.
- Retroviral_aspartyl_protease wikiPageUsesTemplate Template:Enzymes.
- Retroviral_aspartyl_protease wikiPageUsesTemplate Template:InterPro_content.
- Retroviral_aspartyl_protease wikiPageUsesTemplate Template:Pfam.
- Retroviral_aspartyl_protease wikiPageUsesTemplate Template:Pfam_box.
- Retroviral_aspartyl_protease wikiPageUsesTemplate Template:Portal_bar.
- Retroviral_aspartyl_protease wikiPageUsesTemplate Template:Reflist.
- Retroviral_aspartyl_protease subject Category:EC_3.4.23.
- Retroviral_aspartyl_protease subject Category:Peptidase.
- Retroviral_aspartyl_protease subject Category:Protein_domains.
- Retroviral_aspartyl_protease hypernym Proteases.
- Retroviral_aspartyl_protease type Biomolecule.
- Retroviral_aspartyl_protease type Protein.
- Retroviral_aspartyl_protease type Domain.
- Retroviral_aspartyl_protease type Thing.
- Retroviral_aspartyl_protease type Q206229.
- Retroviral_aspartyl_protease type Q8054.
- Retroviral_aspartyl_protease comment "Retroviral aspartyl proteases are single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger pol or gag polyprotein. Retroviral proteases are homologous to a single domain of the two-domain eukaryotic aspartyl proteases such as pepsins, cathepsins, and renins (Pfam PF00026). Aspartic endopeptidases EC 3.4.23. of vertebrate, fungal and retroviral origin have been characterised.".
- Retroviral_aspartyl_protease label "Retroviral aspartyl protease".
- Retroviral_aspartyl_protease sameAs Q7317091.
- Retroviral_aspartyl_protease sameAs m.0dgqsb1.
- Retroviral_aspartyl_protease sameAs Q7317091.
- Retroviral_aspartyl_protease wasDerivedFrom Retroviral_aspartyl_protease?oldid=701723796.
- Retroviral_aspartyl_protease isPrimaryTopicOf Retroviral_aspartyl_protease.