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- Reticulon_4 abstract "Reticulon-4, also known as Neurite outgrowth inhibitor or Nogo, is a protein that in humans is encoded by the RTN4 gene that has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. During neural development Nogo is expressed mainly by neurons and provides an inhibitory signal for the migration and sprouting of CNS endothelial (tip) cells, thereby restricting blood vessel density.This gene belongs to the family of reticulon-encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor that may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. There are three isoforms: Nogo A, B and C. Nogo-A has two known inhibitory domains including amino-Nogo, at the N-terminus and Nogo-66, which makes up the molecules extracellular loop. Both amino-Nogo and Nogo-66 are involved in inhibitory responses, where amino-Nogo is a strong inhibitor of neurite outgrowth, and Nogo-66 is involved in growth cone destruction.Research suggests that blocking Nogo-A during neuronal damage (from diseases such as Multiple Sclerosis) will help to protect or restore the damaged neurons. The investigation into the mechanisms of this protein presents a great potential for the treatment of auto-immune mediated demyelinating diseases and spinal cord injury regeneration. It has also been found to be a key player in the process whereby physical exercise enhances learning and memory processes in the brain.".
- Reticulon_4 entrezgene "57142".
- Reticulon_4 wikiPageID "14725471".
- Reticulon_4 wikiPageLength "12161".
- Reticulon_4 wikiPageOutDegree "19".
- Reticulon_4 wikiPageRevisionID "695456840".
- Reticulon_4 wikiPageWikiLink Autoimmune_disease.
- Reticulon_4 wikiPageWikiLink BCL2-like_1_(gene).
- Reticulon_4 wikiPageWikiLink Bcl-2.
- Reticulon_4 wikiPageWikiLink Category:Enzyme_inhibitors.
- Reticulon_4 wikiPageWikiLink Central_nervous_system.
- Reticulon_4 wikiPageWikiLink Demyelinating_disease.
- Reticulon_4 wikiPageWikiLink Enzyme_inhibitor.
- Reticulon_4 wikiPageWikiLink Gene.
- Reticulon_4 wikiPageWikiLink Growth_cone.
- Reticulon_4 wikiPageWikiLink Multiple_sclerosis.
- Reticulon_4 wikiPageWikiLink Neurite.
- Reticulon_4 wikiPageWikiLink Neuroregeneration.
- Reticulon_4 wikiPageWikiLink Protein.
- Reticulon_4 wikiPageWikiLink Protein_isoform.
- Reticulon_4 wikiPageWikiLink Protein–protein_interaction.
- Reticulon_4 wikiPageWikiLink Reticulon.
- Reticulon_4 wikiPageWikiLink Reticulon_4_receptor.
- Reticulon_4 wikiPageWikiLink Spinal_cord_injury.
- Reticulon_4 wikiPageWikiLink WWP1.
- Reticulon_4 wikiPageWikiLinkText "RTN4".
- Reticulon_4 wikiPageWikiLinkText "Reticulon 4".
- Reticulon_4 wikiPageWikiLinkText "reticulon 4".
- Reticulon_4 wikiPageUsesTemplate Template:Cite_journal.
- Reticulon_4 wikiPageUsesTemplate Template:PBB.
- Reticulon_4 wikiPageUsesTemplate Template:PDB_Gallery.
- Reticulon_4 wikiPageUsesTemplate Template:Refbegin.
- Reticulon_4 wikiPageUsesTemplate Template:Refend.
- Reticulon_4 wikiPageUsesTemplate Template:Reflist.
- Reticulon_4 subject Category:Enzyme_inhibitors.
- Reticulon_4 hypernym Protein.
- Reticulon_4 type Biomolecule.
- Reticulon_4 type Drug.
- Reticulon_4 type Protein.
- Reticulon_4 type Drug.
- Reticulon_4 type Inhibitor.
- Reticulon_4 type Thing.
- Reticulon_4 type Q206229.
- Reticulon_4 type Q8054.
- Reticulon_4 comment "Reticulon-4, also known as Neurite outgrowth inhibitor or Nogo, is a protein that in humans is encoded by the RTN4 gene that has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. During neural development Nogo is expressed mainly by neurons and provides an inhibitory signal for the migration and sprouting of CNS endothelial (tip) cells, thereby restricting blood vessel density.This gene belongs to the family of reticulon-encoding genes.".
- Reticulon_4 label "Reticulon 4".
- Reticulon_4 sameAs Q18042923.
- Reticulon_4 sameAs m.03gvnll.
- Reticulon_4 sameAs Ретикулон-4.
- Reticulon_4 sameAs Q18042923.
- Reticulon_4 wasDerivedFrom Reticulon_4?oldid=695456840.
- Reticulon_4 isPrimaryTopicOf Reticulon_4.