Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Repressor_lexA> ?p ?o }
Showing triples 1 to 82 of
82
with 100 triples per page.
- Repressor_lexA abstract "Repressor LexA or LexA is a transcriptional repressor (EC 3.4.21.88) that represses SOS response genes coding primarily for error-prone DNA polymerases, DNA repair enzymes and cell division inhibitors. LexA forms de facto a two-component regulatory system with RecA, which senses DNA damage at stalled replication forks, forming monofilaments and acquiring an active conformation capable of binding to LexA and causing LexA to cleave itself, in a process called autoproteolysis.DNA damage can be inflicted by the action of antibiotics, bacteriophages and UV light. Of potential clinical interest is the induction of the SOS response by antibiotics, such as ciprofloxacin. Bacteria require topoisomerases such as DNA gyrase or topoisomerase IV for DNA replication. Antibiotics such as ciprofloxacin are able to prevent the action of these molecules by attaching themselves to the gyrase - DNA complex, leading to replication fork stall and the induction of the SOS response. The expression of error-prone polymerases under the SOS response increases the basal mutation rate of bacteria. While mutations are often lethal to the cell, they can also enhance survival. In the specific case of topoisomerases, some bacteria have mutated one of their amino acids so that the ciproflaxin can only create a weak bond to the topoisomerase. This is one of the methods that bacteria use to become resistant to antibiotics. Ciprofloxacin treatment can therefore potentially lead to the generation of mutations that may render bacteria resistant to ciprofloxacin. In addition, ciprofloxacin has also been shown to induce via the SOS response dissemination of virulence factors and antibiotic resistance determinants, as well as the activation of integron integrases, potentially increasing the likelihood of acquisition and dissemination of antibiotic resistance by bacteria.Impaired LexA proteolysis has been shown to interfere with ciprofloxacin resistance. This offers potential for combination therapy that combines quinolones with strategies aimed at interfering with the action of LexA, either directly or via RecA.LexA contains a DNA binding domain. The winged HTH motif of LexA is a variant form of the helix-turn-helix DNA binding motif. it is usually located at the N-terminus of the protein.".
- Repressor_lexA symbol "LexA_DNA_bind".
- Repressor_lexA thumbnail PDB_1jhh_EBI.jpg?width=300.
- Repressor_lexA wikiPageID "1910927".
- Repressor_lexA wikiPageLength "5754".
- Repressor_lexA wikiPageOutDegree "40".
- Repressor_lexA wikiPageRevisionID "701536150".
- Repressor_lexA wikiPageWikiLink Antibiotics.
- Repressor_lexA wikiPageWikiLink Antimicrobial_resistance.
- Repressor_lexA wikiPageWikiLink Bacteriophage.
- Repressor_lexA wikiPageWikiLink Category:Bacterial_proteins.
- Repressor_lexA wikiPageWikiLink Category:DNA_replication.
- Repressor_lexA wikiPageWikiLink Category:EC_3.4.21.
- Repressor_lexA wikiPageWikiLink Category:Protein_domains.
- Repressor_lexA wikiPageWikiLink Cell_division.
- Repressor_lexA wikiPageWikiLink Ciprofloxacin.
- Repressor_lexA wikiPageWikiLink Combination_therapy.
- Repressor_lexA wikiPageWikiLink DNA.
- Repressor_lexA wikiPageWikiLink DNA_gyrase.
- Repressor_lexA wikiPageWikiLink DNA_polymerase.
- Repressor_lexA wikiPageWikiLink DNA_repair.
- Repressor_lexA wikiPageWikiLink DNA_replication.
- Repressor_lexA wikiPageWikiLink Enzyme.
- Repressor_lexA wikiPageWikiLink Gene.
- Repressor_lexA wikiPageWikiLink Helix-turn-helix.
- Repressor_lexA wikiPageWikiLink Integrase.
- Repressor_lexA wikiPageWikiLink Integron.
- Repressor_lexA wikiPageWikiLink Molecular_binding.
- Repressor_lexA wikiPageWikiLink N-terminus.
- Repressor_lexA wikiPageWikiLink Protein_domain.
- Repressor_lexA wikiPageWikiLink Proteolysis.
- Repressor_lexA wikiPageWikiLink Quinolone.
- Repressor_lexA wikiPageWikiLink RecA.
- Repressor_lexA wikiPageWikiLink Repressor.
- Repressor_lexA wikiPageWikiLink SOS_response.
- Repressor_lexA wikiPageWikiLink Structural_motif.
- Repressor_lexA wikiPageWikiLink Topoisomerase.
- Repressor_lexA wikiPageWikiLink Topoisomerase_IV.
- Repressor_lexA wikiPageWikiLink Two-component_regulatory_system.
- Repressor_lexA wikiPageWikiLink Ultraviolet.
- Repressor_lexA wikiPageWikiLink Virulence_factor.
- Repressor_lexA wikiPageWikiLinkText "E. coli LexA repressor".
- Repressor_lexA wikiPageWikiLinkText "LexA".
- Repressor_lexA wikiPageWikiLinkText "Repressor lexA".
- Repressor_lexA wikiPageWikiLinkText "lexA".
- Repressor_lexA caption "lexa s119a mutant".
- Repressor_lexA interpro "IPR006199".
- Repressor_lexA name "LexA DNA binding domain".
- Repressor_lexA pfam "PF01726".
- Repressor_lexA pfamClan "CL0123".
- Repressor_lexA scop "1".
- Repressor_lexA symbol "LexA_DNA_bind".
- Repressor_lexA wikiPageUsesTemplate Template:EC_number.
- Repressor_lexA wikiPageUsesTemplate Template:Enzymes.
- Repressor_lexA wikiPageUsesTemplate Template:Infobox_protein_family.
- Repressor_lexA wikiPageUsesTemplate Template:InterPro_content.
- Repressor_lexA wikiPageUsesTemplate Template:Portal_bar.
- Repressor_lexA wikiPageUsesTemplate Template:Reflist.
- Repressor_lexA wikiPageUsesTemplate Template:Serine_endopeptidases.
- Repressor_lexA subject Category:Bacterial_proteins.
- Repressor_lexA subject Category:DNA_replication.
- Repressor_lexA subject Category:EC_3.4.21.
- Repressor_lexA subject Category:Protein_domains.
- Repressor_lexA hypernym Repressor.
- Repressor_lexA type Biomolecule.
- Repressor_lexA type Protein.
- Repressor_lexA type Chemical.
- Repressor_lexA type Domain.
- Repressor_lexA type Redirect.
- Repressor_lexA type Thing.
- Repressor_lexA type Q206229.
- Repressor_lexA type Q8054.
- Repressor_lexA comment "Repressor LexA or LexA is a transcriptional repressor (EC 3.4.21.88) that represses SOS response genes coding primarily for error-prone DNA polymerases, DNA repair enzymes and cell division inhibitors.".
- Repressor_lexA label "Repressor lexA".
- Repressor_lexA sameAs Q7314274.
- Repressor_lexA sameAs m.065k8t.
- Repressor_lexA sameAs Represor_LexA.
- Repressor_lexA sameAs Represor_LexA.
- Repressor_lexA sameAs Q7314274.
- Repressor_lexA wasDerivedFrom Repressor_lexA?oldid=701536150.
- Repressor_lexA depiction PDB_1jhh_EBI.jpg.
- Repressor_lexA isPrimaryTopicOf Repressor_lexA.