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- Radical_SAM abstract "Radical SAM is a designation for group of enzymatic reactions sharing the property that an iron-sulfur cluster in the enzyme cleaves S-Adenosyl methionine (SAM) reductively to produce a radical, usually a 5′-deoxyadenosyl radical, as a critical intermediate. The radical intermediate allows enzymes to perform a wide variety of unusual chemical transformations. Examples of radical SAM enzymes include various enzymes of cofactor biosynthesis, enzyme activation, peptide modification, metalloprotein cluster formation, tRNA modification, lipid metabolism, etc. The vast majority of known radical SAM enzymes belong to the radical SAM superfamily, and have a cysteine-rich motif that matches or resembles CxxxCxxC.Examples of radical SAM enzymes found within the radical SAM superfamily include: AblA - lysine 2,3-aminomutase (osmolyte biosynthesis - N-epsilon-acetyl-beta-lysine) AlbA - subtilosin maturase (peptide modification) AtsB - anaerobic sulfatase activase (enzyme activation) BchE - anaerobic magnesium protoporphyrin-IX oxidative cyclase (cofactor biosynthesis - chlorophyll) BioB - biotin synthase (cofactor biosynthesis - biotin) BlsE - cytosylglucuronic acid decarboxylase - blasticidin S biosynthesis BtrN - butirosin biosynthesis pathway oxidoreductase (aminoglycoside antibiotic biosynthesis) CofG - FO synthase, CofG subunit (cofactor biosynthesis - F420) CofH - FO synthase, CofH subunit (cofactor biosynthesis - F420) CutD - trimethylamine lyase-activating enzyme DesII - D-desosamine biosynthesis deaminase (sugar modification for macrolide antibiotic biosynthesis) EpmB - elongation factor P beta-lysylation protein (protein modification) HemN - oxygen-independent coproporphyrinogen III oxidase (cofactor biosynthesis - heme) HmdB - 5,10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdB (note unusual CX5CX2C motif) HpnR - hopanoid C-3 methylase (lipid biosynthesis - 3-methylhopanoid production) HydE - [FeFe] hydrogenase H-cluster radical SAM maturase (metallocluster assembly) HydG - [FeFe] hydrogenase H-cluster radical SAM maturase (metallocluster assembly) LipA - lipoyl synthase (cofactor biosynthesis - lipoyl) MftC - mycofactocin system maturase (peptide modification/cofactor biosynthesis - predicted) MiaB - tRNA methylthiotransferase (tRNA modification) MoaA - Mo cofactor biosynthesis protein A (cofactor biosynthesis - molybdenum cofactor) MqnC - dehypoxanthine futalosine cyclase (cofactor biosynthesis - menaquinone via futalosine) MqnE - aminofutalosine synthase (cofactor biosynthesis - menaquinone via futalosine) NifB - cofactor biosynthesis protein nifB (cofactor biosynthesis - FeMo cofactor) NirJ - heme d1 biosynthesis radical SAM protein NirJ (cofactor biosynthesis - heme d1) NosL - complex rearrangement of tryptophan to 3-methyl-2-indolic acid - nosiheptide biosynthesis NrdG - anaerobic ribonucleoside-triphosphate reductase activase (enzyme activation) PflA - pyruvate formate-lyase activating enzyme (enzyme activation) PqqE - PQQ biosynthesis enzyme (peptide modification / cofactor biosynthesis - PQQ) PylB - pyrrolysine biosynthesis protein PylB (amino acid biosynthesis - pyrrolysine) QhpD (PeaB) - quinohemoprotein amine dehydrogenase maturation protein (enzyme activation) QueE - 7-carboxy-7-deazaguanine (CDG) synthase RimO - ribosomal protein S12 methylthiotransferase RlmN - 23S rRNA m2A2503 methyltransferase (rRNA modification) ScfB - SCIFF maturase (peptide modification - predicted) SkfB - sporulation killing factor maturase SplB - spore photoproduct lyase (DNA repair) ThiH - thiazole biosynthesis protein ThiH (cofactor biosynthesis - thiamine) TsrT - tryptophan 2-C-methyltransferase (amino acid modification - antibiotic biosynthesis) TYW1 - 4-demethylwyosine synthase (tRNA modification) YqeV - tRNA methylthiotransferase (tRNA modification)In addition, several non-canonical radical SAM enzymes have been described. These cannot be recognized by the Pfam hidden Markov model PF04055, but still use three Cys residues as ligands to a 4Fe4S cluster and produce a radical from S-adenosylmethionine. These include ThiC (PF01964) - thiamine biosynthesis protein ThiC (cofactor biosynthesis - thiamine) (Cys residues near extreme C-terminus) Dph2 (PF01866) - diphthamide biosynthesis enzyme Dph2 (protein modification - diphthamide in translation elongation factor 2) (note different radical production, a 3-amino-3-carboxypropyl radical) PhnJ (PF06007) - phosphonate metabolism protein PhnJ (C-P phosphonate bond cleavage)".
- Radical_SAM symbol "Radical_SAM".
- Radical_SAM wikiPageExternalLink reactions.
- Radical_SAM wikiPageID "36467539".
- Radical_SAM wikiPageLength "8471".
- Radical_SAM wikiPageOutDegree "38".
- Radical_SAM wikiPageRevisionID "704306873".
- Radical_SAM wikiPageWikiLink Aminoglycoside.
- Radical_SAM wikiPageWikiLink Biotin.
- Radical_SAM wikiPageWikiLink Blasticidin_S.
- Radical_SAM wikiPageWikiLink Category:Enzymes.
- Radical_SAM wikiPageWikiLink Chlorophyll.
- Radical_SAM wikiPageWikiLink Coenzyme_F420.
- Radical_SAM wikiPageWikiLink Cofactor_(biochemistry).
- Radical_SAM wikiPageWikiLink Cysteine.
- Radical_SAM wikiPageWikiLink DNA_repair.
- Radical_SAM wikiPageWikiLink Diphthamide.
- Radical_SAM wikiPageWikiLink Enzyme.
- Radical_SAM wikiPageWikiLink Enzyme_catalysis.
- Radical_SAM wikiPageWikiLink Heme.
- Radical_SAM wikiPageWikiLink Hidden_Markov_model.
- Radical_SAM wikiPageWikiLink Hydrogenase.
- Radical_SAM wikiPageWikiLink Lysine_2,3-aminomutase.
- Radical_SAM wikiPageWikiLink Macrolide.
- Radical_SAM wikiPageWikiLink Metalloprotein.
- Radical_SAM wikiPageWikiLink Molybdenum_cofactor.
- Radical_SAM wikiPageWikiLink Nosiheptide.
- Radical_SAM wikiPageWikiLink Osmolyte.
- Radical_SAM wikiPageWikiLink PQQ.
- Radical_SAM wikiPageWikiLink Peptide.
- Radical_SAM wikiPageWikiLink Pfam.
- Radical_SAM wikiPageWikiLink Phosphonate.
- Radical_SAM wikiPageWikiLink Pyrrolysine.
- Radical_SAM wikiPageWikiLink Radical_(chemistry).
- Radical_SAM wikiPageWikiLink Radical_SAM_superfamily.
- Radical_SAM wikiPageWikiLink Ribosomal_RNA.
- Radical_SAM wikiPageWikiLink S-Adenosyl_methionine.
- Radical_SAM wikiPageWikiLink Spore_photoproduct_lyase.
- Radical_SAM wikiPageWikiLink Thiamine.
- Radical_SAM wikiPageWikiLink Transfer_RNA.
- Radical_SAM wikiPageWikiLink Vitamin_K2.
- Radical_SAM wikiPageWikiLinkText "radical ''S''-adenosyl methionine (SAM) methyltransferases".
- Radical_SAM wikiPageWikiLinkText "radical SAM".
- Radical_SAM interpro "IPR007197".
- Radical_SAM name "Radical_SAM".
- Radical_SAM pfam "PF04055".
- Radical_SAM scop "102114".
- Radical_SAM symbol "Radical_SAM".
- Radical_SAM wikiPageUsesTemplate Template:Infobox_protein_family.
- Radical_SAM wikiPageUsesTemplate Template:Reflist.
- Radical_SAM subject Category:Enzymes.
- Radical_SAM hypernym Designation.
- Radical_SAM type Biomolecule.
- Radical_SAM type Place.
- Radical_SAM type Protein.
- Radical_SAM type Thing.
- Radical_SAM type Q206229.
- Radical_SAM type Q8054.
- Radical_SAM comment "Radical SAM is a designation for group of enzymatic reactions sharing the property that an iron-sulfur cluster in the enzyme cleaves S-Adenosyl methionine (SAM) reductively to produce a radical, usually a 5′-deoxyadenosyl radical, as a critical intermediate. The radical intermediate allows enzymes to perform a wide variety of unusual chemical transformations.".
- Radical_SAM label "Radical SAM".
- Radical_SAM sameAs Q7280456.
- Radical_SAM sameAs m.0k8yms6.
- Radical_SAM sameAs Q7280456.
- Radical_SAM wasDerivedFrom Radical_SAM?oldid=704306873.
- Radical_SAM isPrimaryTopicOf Radical_SAM.