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- Proerythroblast abstract "A proerythroblast (or rubriblast, or pronormoblast) is the earliest of four stages in development of the normoblast.In histology, it is very difficult to distinguish it from the other \"-blast\" cells (lymphoblast, myeloblast, monoblast, and megakaryoblast). The cytoplasm is blue in an H&E stain, indicating that it is basophilic.Proerythroblasts arise from the CFU-e (colony-forming unit erythroid) cells, and give rise to basophilic erythroblasts. In the mouse, proerythroblasts are large committed progenitors that express high levels of transferrin receptor (iron acquisition receptor), the erythropoietin receptor (EpoR), some c-Kit (stem cell factor receptor), and are Ter119 (cell surface molecule)-positive. Their proliferative capacity is more limited compared to the preceding stage, the CFU-e.In vivo, starting with the proerythroblast stage, erythroid cells undergo several more cell divisions while at the same time upregulating survival genes such as Bcl-xL, acquiring and storing large amounts of iron, ramping up the synthesis of hemoglobin and other erythroid genes (in large part a GATA-1 dependent process that is augmented by the EpoR signaling) and decreasing in cell size, eventually removing their nuclei and being released into the bloodstream as a reticulocyte.".
- Proerythroblast thumbnail Proerythroblast.png?width=300.
- Proerythroblast wikiPageExternalLink tsld020.htm.
- Proerythroblast wikiPageExternalLink Medula%20osea%20hemopoiesis24.htm.
- Proerythroblast wikiPageExternalLink nrbc14.html.
- Proerythroblast wikiPageExternalLink sld015.htm.
- Proerythroblast wikiPageID "2966983".
- Proerythroblast wikiPageLength "3289".
- Proerythroblast wikiPageOutDegree "30".
- Proerythroblast wikiPageRevisionID "664546295".
- Proerythroblast wikiPageWikiLink Basophilic.
- Proerythroblast wikiPageWikiLink Bcl-xL.
- Proerythroblast wikiPageWikiLink CFU-E.
- Proerythroblast wikiPageWikiLink Category:Blood_cells.
- Proerythroblast wikiPageWikiLink Cell_adhesion_molecule.
- Proerythroblast wikiPageWikiLink Cell_division.
- Proerythroblast wikiPageWikiLink Cell_nucleus.
- Proerythroblast wikiPageWikiLink Cellular_differentiation.
- Proerythroblast wikiPageWikiLink Cytoplasm.
- Proerythroblast wikiPageWikiLink Erythropoietin_receptor.
- Proerythroblast wikiPageWikiLink GATA1.
- Proerythroblast wikiPageWikiLink H&E_stain.
- Proerythroblast wikiPageWikiLink Hemoglobin.
- Proerythroblast wikiPageWikiLink Histology.
- Proerythroblast wikiPageWikiLink In_vivo.
- Proerythroblast wikiPageWikiLink Iron.
- Proerythroblast wikiPageWikiLink Lymphoblast.
- Proerythroblast wikiPageWikiLink Megakaryoblast.
- Proerythroblast wikiPageWikiLink Monoblast.
- Proerythroblast wikiPageWikiLink Mouse.
- Proerythroblast wikiPageWikiLink Myeloblast.
- Proerythroblast wikiPageWikiLink Normoblast.
- Proerythroblast wikiPageWikiLink Pernicious_anemia.
- Proerythroblast wikiPageWikiLink Progenitor_cell.
- Proerythroblast wikiPageWikiLink Red_blood_cell.
- Proerythroblast wikiPageWikiLink Reticulocyte.
- Proerythroblast wikiPageWikiLink Stem_cell_factor.
- Proerythroblast wikiPageWikiLink Synonym.
- Proerythroblast wikiPageWikiLink Transferrin_receptor.
- Proerythroblast wikiPageWikiLinkText "Proerythroblast".
- Proerythroblast wikiPageWikiLinkText "proerythroblast".
- Proerythroblast caption "A comprehensive diagram of human hematopoiesis".
- Proerythroblast caption "Proerythroblast".
- Proerythroblast image "Hematopoiesis diagram.png".
- Proerythroblast name "Proerythroblast".
- Proerythroblast wikiPageUsesTemplate Template:BUHistology.
- Proerythroblast wikiPageUsesTemplate Template:Blood_physiology.
- Proerythroblast wikiPageUsesTemplate Template:Fact.
- Proerythroblast wikiPageUsesTemplate Template:Infobox_anatomy.
- Proerythroblast wikiPageUsesTemplate Template:KansasHistology.
- Proerythroblast wikiPageUsesTemplate Template:OklahomaHistology.
- Proerythroblast wikiPageUsesTemplate Template:TerminologiaHistologica.
- Proerythroblast subject Category:Blood_cells.
- Proerythroblast type AnatomicalStructure.
- Proerythroblast type Cell.
- Proerythroblast type Thing.
- Proerythroblast type Q4936952.
- Proerythroblast comment "A proerythroblast (or rubriblast, or pronormoblast) is the earliest of four stages in development of the normoblast.In histology, it is very difficult to distinguish it from the other \"-blast\" cells (lymphoblast, myeloblast, monoblast, and megakaryoblast). The cytoplasm is blue in an H&E stain, indicating that it is basophilic.Proerythroblasts arise from the CFU-e (colony-forming unit erythroid) cells, and give rise to basophilic erythroblasts.".
- Proerythroblast label "Proerythroblast".
- Proerythroblast sameAs Q2284254.
- Proerythroblast sameAs Proerytroblast.
- Proerythroblast sameAs Rubriblas.
- Proerythroblast sameAs Pro-erytroblast.
- Proerythroblast sameAs Proerytroblast.
- Proerythroblast sameAs m.025sjr8.
- Proerythroblast sameAs Проэритробласт.
- Proerythroblast sameAs Proerytroblast.
- Proerythroblast sameAs Q2284254.
- Proerythroblast wasDerivedFrom Proerythroblast?oldid=664546295.
- Proerythroblast depiction Proerythroblast.png.
- Proerythroblast isPrimaryTopicOf Proerythroblast.
- Proerythroblast name "Proerythroblast".