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- Piquindone abstract "Piquindone (Ro 22-1319) is an atypical antipsychotic with a tricyclic structure that was developed in the 1980s but was never marketed. It acts as a selective D2 receptor antagonist, though based on its effects profile its selectivity may be considered controversial. Unlike most other D2 receptor ligands, piquindone displays Na2+-dependent binding, a property it shares with tropapride, zetidoline, and metoclopramide.In clinical trials piquindone was found to possess moderate efficacy in treating positive symptoms of schizophrenia, and notably, was also modestly effective for negative symptoms, though this was just under statistical significance. Additionally, relative to haloperidol, it was found to possesses significantly fewer extrapyramidal symptoms and had a much lower propensity for inducing tardive dyskinesia, indicating its atypical nature. In addition to psychosis, piquindone has also been found to be effective in the treatment of Tourette's syndrome in numerous clinical studies.".
- Piquindone atcPrefix "none".
- Piquindone casNumber "78541-97-6".
- Piquindone casSupplemental "83784-19-4 (hydrochloride)".
- Piquindone fdaUniiCode "O1C9WXY65C".
- Piquindone iupacName "(4aS,8aS)-3-ethyl-2,6-dimethyl-1,4a,5,6,7,8,8a,9-octahydro-4H-pyrrolo[2,3-g]isoquinolin-4-one".
- Piquindone pubchem "121903".
- Piquindone thumbnail Piquindone.png?width=300.
- Piquindone wikiPageID "26907451".
- Piquindone wikiPageLength "6727".
- Piquindone wikiPageOutDegree "24".
- Piquindone wikiPageRevisionID "679014045".
- Piquindone wikiPageWikiLink Atypical_antipsychotic.
- Piquindone wikiPageWikiLink Binding_selectivity.
- Piquindone wikiPageWikiLink Category:Atypical_antipsychotics.
- Piquindone wikiPageWikiLink Category:Pyrroloisoquinolines.
- Piquindone wikiPageWikiLink Chemical_structure.
- Piquindone wikiPageWikiLink Clinical_trial.
- Piquindone wikiPageWikiLink Dopamine_receptor_D2.
- Piquindone wikiPageWikiLink Extrapyramidal_symptoms.
- Piquindone wikiPageWikiLink Haloperidol.
- Piquindone wikiPageWikiLink Hydrochloride.
- Piquindone wikiPageWikiLink Losindole.
- Piquindone wikiPageWikiLink Metoclopramide.
- Piquindone wikiPageWikiLink Molecular_binding.
- Piquindone wikiPageWikiLink Molindone.
- Piquindone wikiPageWikiLink Psychosis.
- Piquindone wikiPageWikiLink Receptor_antagonist.
- Piquindone wikiPageWikiLink Schizophrenia.
- Piquindone wikiPageWikiLink Sodium.
- Piquindone wikiPageWikiLink Tardive_dyskinesia.
- Piquindone wikiPageWikiLink Tourette_syndrome.
- Piquindone wikiPageWikiLink Tricyclic.
- Piquindone wikiPageWikiLink Tropapride.
- Piquindone wikiPageWikiLink Zetidoline.
- Piquindone wikiPageWikiLinkText "Piquindone".
- Piquindone wikiPageWikiLinkText "piquindone".
- Piquindone atcPrefix "none".
- Piquindone c "15".
- Piquindone casNumber "78541".
- Piquindone casSupplemental "83784".
- Piquindone chembl "1192678".
- Piquindone chemspiderid "108751".
- Piquindone h "22".
- Piquindone iupacName "-3".
- Piquindone legalStatus "Uncontrolled".
- Piquindone molecularWeight "246.35".
- Piquindone n "2".
- Piquindone o "1".
- Piquindone pubchem "121903".
- Piquindone routesOfAdministration "Oral".
- Piquindone smiles "O=C2c1cC[C@H]3[C@H]2CNC".
- Piquindone unii "O1C9WXY65C".
- Piquindone wikiPageUsesTemplate Template:Antipsychotics.
- Piquindone wikiPageUsesTemplate Template:Dopaminergics.
- Piquindone wikiPageUsesTemplate Template:Drugbox.
- Piquindone wikiPageUsesTemplate Template:Fdacite.
- Piquindone wikiPageUsesTemplate Template:Reflist.
- Piquindone wikiPageUsesTemplate Template:Tricyclics.
- Piquindone subject Category:Atypical_antipsychotics.
- Piquindone subject Category:Pyrroloisoquinolines.
- Piquindone type ChemicalSubstance.
- Piquindone type Drug.
- Piquindone type Antagonist.
- Piquindone type Drug.
- Piquindone type Heterocycle.
- Piquindone type ChemicalObject.
- Piquindone type Thing.
- Piquindone type Q8386.
- Piquindone comment "Piquindone (Ro 22-1319) is an atypical antipsychotic with a tricyclic structure that was developed in the 1980s but was never marketed. It acts as a selective D2 receptor antagonist, though based on its effects profile its selectivity may be considered controversial.".
- Piquindone label "Piquindone".
- Piquindone sameAs Q7197544.
- Piquindone sameAs ピキンドン.
- Piquindone sameAs m.0bmgntz.
- Piquindone sameAs Pihindon.
- Piquindone sameAs Pihindon.
- Piquindone sameAs Q7197544.
- Piquindone wasDerivedFrom Piquindone?oldid=679014045.
- Piquindone depiction Piquindone.png.
- Piquindone isPrimaryTopicOf Piquindone.