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- Phorbol abstract "Phorbol is a natural, plant-derived organic compound. It is a member of the tigliane family of diterpenes. Phorbol was first isolated in 1934 as the hydrolysis product of croton oil, which is derived from the seeds of the purging croton, Croton tiglium. The structure of phorbol was determined in 1967. Phorbol is identified as the active constituent of the highly toxic New World tropical manchineel or 'beach apple' Hippomane mancinella. It is very soluble in most polar organic solvents, as well as in water. In the manchineel, this leads to an additional exposure risk during rain, where liquid splashing from an undamaged tree may also be injurious.Various esters of phorbol have important biological properties, the most notable of which is the capacity to act as tumor promoters through activation of protein kinase C. They mimic diacylglycerols, glycerol derivatives in which two hydroxyl groups have reacted with fatty acids to form esters. The most common phorbol ester is 12-O-tetradecanoylphorbol-13-acetate (TPA), also called phorbol-12-myristate-13-acetate (PMA), which is used as a biomedical research tool in models of carcinogenesis. TPA, together with ionomycin, can also be used to stimulate T-cell activation, proliferation, and cytokine production, and is used in protocols for intracellular staining of these cytokines.".
- Phorbol iupacName "1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one".
- Phorbol thumbnail Phorbol.svg?width=300.
- Phorbol wikiPageID "4500344".
- Phorbol wikiPageLength "6524".
- Phorbol wikiPageOutDegree "21".
- Phorbol wikiPageRevisionID "698906681".
- Phorbol wikiPageWikiLink 12-O-Tetradecanoylphorbol-13-acetate.
- Phorbol wikiPageWikiLink Carcinogenesis.
- Phorbol wikiPageWikiLink Category:Alcohols.
- Phorbol wikiPageWikiLink Category:Benzoazulenes.
- Phorbol wikiPageWikiLink Category:Diterpenes.
- Phorbol wikiPageWikiLink Category:Ketones.
- Phorbol wikiPageWikiLink Chemical_polarity.
- Phorbol wikiPageWikiLink Croton_oil.
- Phorbol wikiPageWikiLink Croton_tiglium.
- Phorbol wikiPageWikiLink Diglyceride.
- Phorbol wikiPageWikiLink Ester.
- Phorbol wikiPageWikiLink Fatty_acid.
- Phorbol wikiPageWikiLink Hydrolysis.
- Phorbol wikiPageWikiLink Ionomycin.
- Phorbol wikiPageWikiLink Manchineel.
- Phorbol wikiPageWikiLink Organic_compound.
- Phorbol wikiPageWikiLink Protein_kinase_C.
- Phorbol wikiPageWikiLink Solvent.
- Phorbol wikiPageWikiLink Terpene.
- Phorbol wikiPageWikiLink Tigliane.
- Phorbol wikiPageWikiLink Tumor_promotion.
- Phorbol wikiPageWikiLinkText "Phorbol esters".
- Phorbol wikiPageWikiLinkText "Phorbol".
- Phorbol wikiPageWikiLinkText "phorbol esters".
- Phorbol wikiPageWikiLinkText "phorbol".
- Phorbol imagefile "Phorbol.svg".
- Phorbol imagename "Phorbol".
- Phorbol iupacname "11".
- Phorbol name "Phorbol".
- Phorbol verifiedfields "changed".
- Phorbol verifiedrevid "390502294".
- Phorbol watchedfields "changed".
- Phorbol wikiPageUsesTemplate Template:Cascite.
- Phorbol wikiPageUsesTemplate Template:Chembox.
- Phorbol wikiPageUsesTemplate Template:Chembox_Identifiers.
- Phorbol wikiPageUsesTemplate Template:Chembox_Properties.
- Phorbol wikiPageUsesTemplate Template:Chemspidercite.
- Phorbol wikiPageUsesTemplate Template:Commonscat.
- Phorbol wikiPageUsesTemplate Template:MeshName.
- Phorbol wikiPageUsesTemplate Template:Reflist.
- Phorbol wikiPageUsesTemplate Template:Stdinchicite.
- Phorbol subject Category:Alcohols.
- Phorbol subject Category:Benzoazulenes.
- Phorbol subject Category:Diterpenes.
- Phorbol subject Category:Ketones.
- Phorbol hypernym Compound.
- Phorbol type ChemicalCompound.
- Phorbol type ChemicalSubstance.
- Phorbol type Group.
- Phorbol type Alcohol.
- Phorbol type Chemical.
- Phorbol type Diterpene.
- Phorbol type Group.
- Phorbol type Hydrocarbon.
- Phorbol type Ketone.
- Phorbol type Terpene.
- Phorbol type ChemicalObject.
- Phorbol type Thing.
- Phorbol type Q11173.
- Phorbol comment "Phorbol is a natural, plant-derived organic compound. It is a member of the tigliane family of diterpenes. Phorbol was first isolated in 1934 as the hydrolysis product of croton oil, which is derived from the seeds of the purging croton, Croton tiglium. The structure of phorbol was determined in 1967. Phorbol is identified as the active constituent of the highly toxic New World tropical manchineel or 'beach apple' Hippomane mancinella.".
- Phorbol label "Phorbol".
- Phorbol sameAs Q2705359.
- Phorbol sameAs Forbol.
- Phorbol sameAs فوربول.
- Phorbol sameAs Forbolo.
- Phorbol sameAs ホルボール.
- Phorbol sameAs Phorbol.
- Phorbol sameAs Forbol.
- Phorbol sameAs Forbol.
- Phorbol sameAs m.0c5r3y.
- Phorbol sameAs Forbol.
- Phorbol sameAs Forbol.
- Phorbol sameAs Q2705359.
- Phorbol sameAs 佛波酯.
- Phorbol wasDerivedFrom Phorbol?oldid=698906681.
- Phorbol depiction Phorbol.svg.
- Phorbol isPrimaryTopicOf Phorbol.
- Phorbol name "Phorbol".