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Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Pfl_RNA_motif> ?p ?o }

• Pfl_RNA_motif abstract "The pfl RNA motif refers to a conserved RNA structure present in some bacteria and originally discovered using bioinformatics. pfl RNAs are consistently present in genomic locations that likely correspond to the 5' untranslated regions (5' UTRs) of protein-coding genes. This arrangement in bacteria is commonly associated with cis-regulatory elements. Moreover, they are in presumed 5' UTRs of multiple non-homologous genes, suggesting that they function only in these locations. Additional evidence of cis-regulatory function came from the observation that predicted rho-independent transcription terminators overlap pfl RNAs. This overlap suggests that the alternate secondary structures of pfl RNA and the transcription terminator stem-loops compete with each other, and this is a common mechanism for cis gene control in bacteria.pfl RNAs are found in a variety of phyla of bacteria, but are not found in all the species of that phylum. pfl RNAs are common among species of orders Actinomycetales and Clostridiales, the classes Alphaproteobacteria and Betaproteobacteria and the genus Deinococcus. They are also found in isolated species of Bacteroidetes, Chloroflexi and deltaproteobacteria.Several lines of evidence led to the hypothesis that pfl RNAs function as riboswitches. First, the above evidence that pfl RNAs correspond to cis-regulatory elements is consistent with most known riboswitches. Second, their relatively complex pseudoknotted secondary structure is typical of riboswitches. Finally, several nucleotide positions are highly conserved despite the large evolutionary distance between species that use pfl RNAs; this high level of conservation is often a consequence of the need to form intricate structures to specifically bind a metabolite. Experimental evidence already supported the hypothesis that pfl RNAs function as cis regulatory elements, before the ligand was confirmed to be ZTP, as well as ZMP, in 2015.The genes presumed to be regulated by pfl RNAs relate to one-carbon metabolism. Most obviously, for example, formate-tetrahydrofolate ligase synthesizes 10-formyltetrahydrofolate. The glyA and folD convert between other one-carbon adducts of tetrahydrofolate. Another gene commonly associated with pfl RNAs is purH, which catalyzes the formylation of the intermediate AICAR in de novo synthesis of purines. The formyl group is taken from formyltetrahydrofolate, and purine biosynthesis is often the dominant user of formyltetrahydrofolate. In similar fashions, if less directly, most pfl RNAs are associated with genes that are directly or indirectly involved in one-carbon metabolism. It appears that the ZTP/ZMP purine derivatives can be used to regulate one-carbon metabolism by indirectly sensing a shortage of 10-formyl-tetrahydrofolate.The atomic-resolution structure has been solved by X-ray crystallography.".
• Pfl_RNA_motif thumbnail Pfl-RNA.svg?width=300.
• Pfl_RNA_motif wikiPageID "26709882".
• Pfl_RNA_motif wikiPageLength "4996".
• Pfl_RNA_motif wikiPageOutDegree "38".
• Pfl_RNA_motif wikiPageRevisionID "696165367".
• Pfl_RNA_motif wikiPageWikiLink 10-Formyltetrahydrofolate.
• Pfl_RNA_motif wikiPageWikiLink AICA_ribonucleotide.
• Pfl_RNA_motif wikiPageWikiLink Actinomycetales.
• Pfl_RNA_motif wikiPageWikiLink Aldehyde.
• Pfl_RNA_motif wikiPageWikiLink Alphaproteobacteria.
• Pfl_RNA_motif wikiPageWikiLink Bacteria.
• Pfl_RNA_motif wikiPageWikiLink Bacteroidetes.
• Pfl_RNA_motif wikiPageWikiLink Betaproteobacteria.
• Pfl_RNA_motif wikiPageWikiLink Bioinformatics.
• Pfl_RNA_motif wikiPageWikiLink Biomolecular_structure.
• Pfl_RNA_motif wikiPageWikiLink Category:Cis-regulatory_RNA_elements.
• Pfl_RNA_motif wikiPageWikiLink Chloroflexi_(phylum).
• Pfl_RNA_motif wikiPageWikiLink Cis-Regulatory_element.
• Pfl_RNA_motif wikiPageWikiLink Class_(biology).
• Pfl_RNA_motif wikiPageWikiLink Clostridia.
• Pfl_RNA_motif wikiPageWikiLink Deinococcus.
• Pfl_RNA_motif wikiPageWikiLink Deltaproteobacteria.
• Pfl_RNA_motif wikiPageWikiLink Five_prime_untranslated_region.
• Pfl_RNA_motif wikiPageWikiLink Formate–tetrahydrofolate_ligase.
• Pfl_RNA_motif wikiPageWikiLink Gene.
• Pfl_RNA_motif wikiPageWikiLink Genome.
• Pfl_RNA_motif wikiPageWikiLink Genus.
• Pfl_RNA_motif wikiPageWikiLink Homology_(biology).
• Pfl_RNA_motif wikiPageWikiLink Intrinsic_termination.
• Pfl_RNA_motif wikiPageWikiLink Ligand.
• Pfl_RNA_motif wikiPageWikiLink Metabolite.
• Pfl_RNA_motif wikiPageWikiLink One-carbon_metabolism.
• Pfl_RNA_motif wikiPageWikiLink Order_(biology).
• Pfl_RNA_motif wikiPageWikiLink Phylum.
• Pfl_RNA_motif wikiPageWikiLink Protein.
• Pfl_RNA_motif wikiPageWikiLink Pseudoknot.
• Pfl_RNA_motif wikiPageWikiLink Purine.
• Pfl_RNA_motif wikiPageWikiLink RNA.
• Pfl_RNA_motif wikiPageWikiLink Riboswitch.
• Pfl_RNA_motif wikiPageWikiLink Species.
• Pfl_RNA_motif wikiPageWikiLink Stem-loop.
• Pfl_RNA_motif wikiPageWikiLink Tetrahydrofolic_acid.
• Pfl_RNA_motif wikiPageWikiLinkText "pfl RNA motif".
• Pfl_RNA_motif caption "Consensus secondary structure of pfl RNAs".
• Pfl_RNA_motif id "RF01750".
• Pfl_RNA_motif name "pfl RNA".
• Pfl_RNA_motif rfam "RF01750".
• Pfl_RNA_motif rnaType "Cis-regulatory element".
• Pfl_RNA_motif symbol "pfl".
• Pfl_RNA_motif taxDomain Bacteria.
• Pfl_RNA_motif wikiPageUsesTemplate Template:Infobox_rfam.
• Pfl_RNA_motif wikiPageUsesTemplate Template:Rfam.
• Pfl_RNA_motif subject Category:Cis-regulatory_RNA_elements.
• Pfl_RNA_motif type Element.
• Pfl_RNA_motif comment "The pfl RNA motif refers to a conserved RNA structure present in some bacteria and originally discovered using bioinformatics. pfl RNAs are consistently present in genomic locations that likely correspond to the 5' untranslated regions (5' UTRs) of protein-coding genes. This arrangement in bacteria is commonly associated with cis-regulatory elements. Moreover, they are in presumed 5' UTRs of multiple non-homologous genes, suggesting that they function only in these locations.".
• Pfl_RNA_motif label "Pfl RNA motif".
• Pfl_RNA_motif sameAs Q7179814.
• Pfl_RNA_motif sameAs m.0bmdj68.
• Pfl_RNA_motif sameAs Q7179814.
• Pfl_RNA_motif wasDerivedFrom Pfl_RNA_motif?oldid=696165367.
• Pfl_RNA_motif depiction Pfl-RNA.svg.
• Pfl_RNA_motif isPrimaryTopicOf Pfl_RNA_motif.