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- Pacemaker_potential abstract "In the pacemaking cells of the heart (e.g., the sinoatrial node), the pacemaker potential (also called the pacemaker current) is the slow, positive increase in voltage across the cell's membrane (the membrane potential) that occurs between the end of one action potential and the beginning of the next action potential. This increase in membrane potential is what causes the cell membrane, which typically maintains a resting membrane potential of -70 mV, to reach the threshold potential and consequently fire the next action potential; thus, the pacemaker potential is what drives the self-generated rhythmic firing (automaticity) of pacemaker cells, and the rate of change (i.e., the slope) of the pacemaker potential is what determines the timing of the next action potential and thus the intrinsic firing rate of the cell. In a healthy sinoatrial node (SAN, a complex tissue within the right atrium containing pacemaker cells that normally determine the intrinsic firing rate for the entire heart), the pacemaker potential is the main determinant of the heart rate. Because the pacemaker potential represents the non-contracting time between heart beats (diastole), it is also called the diastolic depolarization.The amount of net inward current required to move the cell membrane potential during the pacemaker phase is extremely small, in the order of few pAs, but this net flux arises from time to time changing contribution of several currents that flow with different voltage and time dependence. Evidence in support of the active presence of K+, Ca2+, Na+ channels and Na+/K+ exchanger during the pacemaker phase have been variously reported in the literature, but several indications point to the “funny”(If) current as one of the most important.(see funny current). There is now substantial evidence that also sarcoplasmic reticulum (SR) Ca2+-transients participate to the generation of the diastolic depolarization via a process involving the Na–Ca exchanger.".
- Pacemaker_potential thumbnail Pacemaker_potential.svg?width=300.
- Pacemaker_potential wikiPageID "598577".
- Pacemaker_potential wikiPageLength "7006".
- Pacemaker_potential wikiPageOutDegree "18".
- Pacemaker_potential wikiPageRevisionID "654688951".
- Pacemaker_potential wikiPageWikiLink Action_potential.
- Pacemaker_potential wikiPageWikiLink Artificial_cardiac_pacemaker.
- Pacemaker_potential wikiPageWikiLink Cardiac_action_potential.
- Pacemaker_potential wikiPageWikiLink Cardiac_muscle_cell.
- Pacemaker_potential wikiPageWikiLink Cardiac_pacemaker.
- Pacemaker_potential wikiPageWikiLink Category:Cardiac_electrophysiology.
- Pacemaker_potential wikiPageWikiLink Cell_membrane.
- Pacemaker_potential wikiPageWikiLink Depolarization.
- Pacemaker_potential wikiPageWikiLink Diastole.
- Pacemaker_potential wikiPageWikiLink Diastolic_depolarization.
- Pacemaker_potential wikiPageWikiLink Funny_current.
- Pacemaker_potential wikiPageWikiLink Heart.
- Pacemaker_potential wikiPageWikiLink Membrane_potential.
- Pacemaker_potential wikiPageWikiLink Myocyte.
- Pacemaker_potential wikiPageWikiLink Sinoatrial_node.
- Pacemaker_potential wikiPageWikiLink Threshold_potential.
- Pacemaker_potential wikiPageWikiLink File:Pacemaker_potential.svg.
- Pacemaker_potential wikiPageWikiLinkText "Pacemaker potential".
- Pacemaker_potential wikiPageWikiLinkText "pacemaker potential".
- Pacemaker_potential wikiPageUsesTemplate Template:Cardiovascular_physiology.
- Pacemaker_potential wikiPageUsesTemplate Template:Reflist.
- Pacemaker_potential subject Category:Cardiac_electrophysiology.
- Pacemaker_potential hypernym Increase.
- Pacemaker_potential type Disease.
- Pacemaker_potential comment "In the pacemaking cells of the heart (e.g., the sinoatrial node), the pacemaker potential (also called the pacemaker current) is the slow, positive increase in voltage across the cell's membrane (the membrane potential) that occurs between the end of one action potential and the beginning of the next action potential.".
- Pacemaker_potential label "Pacemaker potential".
- Pacemaker_potential sameAs Q3909524.
- Pacemaker_potential sameAs Potenziale_delle_cellule_segnapassi.
- Pacemaker_potential sameAs m.02v06g.
- Pacemaker_potential sameAs Q3909524.
- Pacemaker_potential wasDerivedFrom Pacemaker_potential?oldid=654688951.
- Pacemaker_potential depiction Pacemaker_potential.svg.
- Pacemaker_potential isPrimaryTopicOf Pacemaker_potential.