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- PPP1R12A abstract "Protein phosphatase 1 regulatory subunit 12A is an enzyme that in humans is encoded by the PPP1R12A gene.Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.".
- PPP1R12A entrezgene "4659".
- PPP1R12A wikiPageExternalLink report.cgi?report=orth_overview&gene_id=4659.
- PPP1R12A wikiPageExternalLink index.shtml.
- PPP1R12A wikiPageID "14756404".
- PPP1R12A wikiPageLength "9012".
- PPP1R12A wikiPageOutDegree "4".
- PPP1R12A wikiPageRevisionID "679004440".
- PPP1R12A wikiPageWikiLink Enzyme.
- PPP1R12A wikiPageWikiLink Gene.
- PPP1R12A wikiPageWikiLink Interleukin_16.
- PPP1R12A wikiPageWikiLink Protein–protein_interaction.
- PPP1R12A wikiPageWikiLinkText "MYPT1".
- PPP1R12A wikiPageWikiLinkText "PPP1R12A".
- PPP1R12A wikiPageWikiLinkText "myosin binding subunit".
- PPP1R12A requireManualInspection "no".
- PPP1R12A summaryText "Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate -bound, active form of RhoA specifically interacted with the myosin-binding subunit of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase , which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.".
- PPP1R12A updateCitations "yes".
- PPP1R12A updatePage "yes".
- PPP1R12A updateProteinBox "yes".
- PPP1R12A updateSummary "yes".
- PPP1R12A wikiPageUsesTemplate Template:Cite_journal.
- PPP1R12A wikiPageUsesTemplate Template:Gene-12-stub.
- PPP1R12A wikiPageUsesTemplate Template:PBB.
- PPP1R12A wikiPageUsesTemplate Template:PBB_Controls.
- PPP1R12A wikiPageUsesTemplate Template:PBB_Further_reading.
- PPP1R12A wikiPageUsesTemplate Template:PBB_Summary.
- PPP1R12A wikiPageUsesTemplate Template:PDB_Gallery.
- PPP1R12A wikiPageUsesTemplate Template:Refbegin.
- PPP1R12A wikiPageUsesTemplate Template:Refend.
- PPP1R12A wikiPageUsesTemplate Template:Reflist.
- PPP1R12A hypernym Enzyme.
- PPP1R12A type Biomolecule.
- PPP1R12A type Protein.
- PPP1R12A type Redirect.
- PPP1R12A type Thing.
- PPP1R12A type Q206229.
- PPP1R12A type Q8054.
- PPP1R12A comment "Protein phosphatase 1 regulatory subunit 12A is an enzyme that in humans is encoded by the PPP1R12A gene.Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho.".
- PPP1R12A label "PPP1R12A".
- PPP1R12A sameAs Q18029818.
- PPP1R12A sameAs m.03gwvn4.
- PPP1R12A sameAs Q18029818.
- PPP1R12A wasDerivedFrom PPP1R12A?oldid=679004440.
- PPP1R12A isPrimaryTopicOf PPP1R12A.