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- PCSK9 abstract "Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans. PCSK9 binds to the receptor for low-density lipoprotein (LDL) cholesterol.In the liver, the LDL receptor removes LDL cholesterol from the blood. When PCSK9 binds to the LDL receptor, the receptor is broken down and can no longer remove LDL cholesterol from the blood. If PCSK9 is blocked, more LDL receptors will be present on the surface of the liver and will remove more LDL cholesterol from the blood. Therefore, blocking PCSK9 can lower blood cholesterol levels. Similar genes (orthologs) are found across many species. PCSK9 is inactive when first synthesized, because a section of peptide chains blocks their activity; proprotein convertases remove that section to activate the enzyme.PCSK9 has medical significance because it acts in cholesterol homeostasis. Drugs can block PCSK9, thus lowering low-density lipoprotein cholesterol (LDL-C). The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved by the U.S. Food and Drug Administration in 2015 for lowering cholesterol where statins and other drugs were insufficient. The manufacturers did not submit data to show that the drugs actually improved outcomes of cardiovascular disease, but they assumed that lowering cholesterol would improve cardiovascular disease.".
- PCSK9 entrezgene "255738".
- PCSK9 wikiPageID "14168046".
- PCSK9 wikiPageLength "33127".
- PCSK9 wikiPageOutDegree "64".
- PCSK9 wikiPageRevisionID "707532450".
- PCSK9 wikiPageWikiLink Alirocumab.
- PCSK9 wikiPageWikiLink Amgen.
- PCSK9 wikiPageWikiLink Annexin_A2.
- PCSK9 wikiPageWikiLink Antibody.
- PCSK9 wikiPageWikiLink Berberine.
- PCSK9 wikiPageWikiLink Biological_target.
- PCSK9 wikiPageWikiLink Bococizumab.
- PCSK9 wikiPageWikiLink Cardiovascular_disease.
- PCSK9 wikiPageWikiLink Cholesterol.
- PCSK9 wikiPageWikiLink Chromosome_1_(human).
- PCSK9 wikiPageWikiLink Coronary_artery_disease.
- PCSK9 wikiPageWikiLink Drug_discovery.
- PCSK9 wikiPageWikiLink Endoplasmic_reticulum.
- PCSK9 wikiPageWikiLink Enzyme.
- PCSK9 wikiPageWikiLink Evolocumab.
- PCSK9 wikiPageWikiLink Familial_hypercholesterolemia.
- PCSK9 wikiPageWikiLink Gene.
- PCSK9 wikiPageWikiLink Hepatocyte.
- PCSK9 wikiPageWikiLink Homeostasis.
- PCSK9 wikiPageWikiLink Homology_(biology).
- PCSK9 wikiPageWikiLink Immunoglobulin_G.
- PCSK9 wikiPageWikiLink LDL_receptor.
- PCSK9 wikiPageWikiLink Liver.
- PCSK9 wikiPageWikiLink Low-density_lipoprotein.
- PCSK9 wikiPageWikiLink Merck_&_Co..
- PCSK9 wikiPageWikiLink Messenger_RNA.
- PCSK9 wikiPageWikiLink Meta-analysis.
- PCSK9 wikiPageWikiLink Monoclonal_antibody.
- PCSK9 wikiPageWikiLink Myocardial_infarction.
- PCSK9 wikiPageWikiLink Nabil_Seidah.
- PCSK9 wikiPageWikiLink Necker-Enfants_Malades_Hospital.
- PCSK9 wikiPageWikiLink Nonsense_mutation.
- PCSK9 wikiPageWikiLink Oligonucleotide.
- PCSK9 wikiPageWikiLink PCSK9.
- PCSK9 wikiPageWikiLink Pfizer.
- PCSK9 wikiPageWikiLink Phases_of_clinical_research.
- PCSK9 wikiPageWikiLink Proprotein_convertase.
- PCSK9 wikiPageWikiLink Proteinase_K.
- PCSK9 wikiPageWikiLink Protein–protein_interaction.
- PCSK9 wikiPageWikiLink RNA_interference.
- PCSK9 wikiPageWikiLink Regeneron.
- PCSK9 wikiPageWikiLink Rockefeller_University.
- PCSK9 wikiPageWikiLink Sanofi.
- PCSK9 wikiPageWikiLink Statin.
- PCSK9 wikiPageWikiLink Subtilase.
- PCSK9 wikiPageWikiLink University_of_Texas_Southwestern_Medical_Center.
- PCSK9 wikiPageWikiLink Virus-like_particle.
- PCSK9 wikiPageWikiLink Zymogen.
- PCSK9 wikiPageWikiLink File:PDB_2p4e_EBI.png.
- PCSK9 wikiPageWikiLink File:PDB_2pmw_EBI.png.
- PCSK9 wikiPageWikiLinkText "PCSK9".
- PCSK9 wikiPageWikiLinkText "PCSK9#As_a_drug_target".
- PCSK9 wikiPageWikiLinkText "a series of discoveries".
- PCSK9 wikiPageWikiLinkText "proprotein convertase subtilisin/kexin type 9 (PCSK9)".
- PCSK9 wikiPageWikiLinkText "proprotein convertase subtilisin/kexin type 9".
- PCSK9 wikiPageUsesTemplate Template:Citation_needed.
- PCSK9 wikiPageUsesTemplate Template:Cite_journal.
- PCSK9 wikiPageUsesTemplate Template:PBB.
- PCSK9 wikiPageUsesTemplate Template:Refbegin.
- PCSK9 wikiPageUsesTemplate Template:Refend.
- PCSK9 wikiPageUsesTemplate Template:Reflist.
- PCSK9 hypernym Enzyme.
- PCSK9 type Biomolecule.
- PCSK9 type Protein.
- PCSK9 type Thing.
- PCSK9 type Q206229.
- PCSK9 type Q8054.
- PCSK9 comment "Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans. PCSK9 binds to the receptor for low-density lipoprotein (LDL) cholesterol.In the liver, the LDL receptor removes LDL cholesterol from the blood. When PCSK9 binds to the LDL receptor, the receptor is broken down and can no longer remove LDL cholesterol from the blood.".
- PCSK9 label "PCSK9".
- PCSK9 sameAs Q3359612.
- PCSK9 sameAs PCSK9.
- PCSK9 sameAs PCSK9.
- PCSK9 sameAs PCSK9.
- PCSK9 sameAs m.03cwp97.
- PCSK9 sameAs PCSK9.
- PCSK9 sameAs Q3359612.
- PCSK9 wasDerivedFrom PCSK9?oldid=707532450.
- PCSK9 isPrimaryTopicOf PCSK9.