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- Orthogonal_ligand-protein_pair abstract "Orthogonal ligand-protein pairs (also known as re-engineered ligand-receptor interfaces or re-engineered enzyme-substrate interactions) are a protein-ligand binding pair made to be independent of the original binding pair. This is done by taking a mutant protein (naturally occurring or selectively engineered), which is activated by a different ligand (carefully synthesized or selected). The intention here is that the orthogonal ligand will not interact with the original protein. The original protein will also be designed to not interact with the orthogonal ligand in certain cases. An example of orthogonal ligand-receptor interfaces are RASSL and DREADD. They are G protein-coupled receptors that are activated by synthesized ligands that wouldn't normally exist in the cell, such as the anti-psychotic Clozapine, allowing researchers to control the interaction externally and independent of internal activation.".
- Orthogonal_ligand-protein_pair thumbnail Myowndiagram2.png?width=300.
- Orthogonal_ligand-protein_pair wikiPageExternalLink PMC3241737.
- Orthogonal_ligand-protein_pair wikiPageExternalLink revus.aspx.
- Orthogonal_ligand-protein_pair wikiPageExternalLink O49686.
- Orthogonal_ligand-protein_pair wikiPageExternalLink P49597.
- Orthogonal_ligand-protein_pair wikiPageExternalLink Q9LD83.
- Orthogonal_ligand-protein_pair wikiPageID "48121588".
- Orthogonal_ligand-protein_pair wikiPageLength "9529".
- Orthogonal_ligand-protein_pair wikiPageOutDegree "28".
- Orthogonal_ligand-protein_pair wikiPageRevisionID "694013969".
- Orthogonal_ligand-protein_pair wikiPageWikiLink Abscisic_acid.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Adenosine_triphosphate.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Allosteric_regulation.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Category:Proteins.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Clozapine.
- Orthogonal_ligand-protein_pair wikiPageWikiLink DNA-binding_domain.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Electrostatics.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Enzyme.
- Orthogonal_ligand-protein_pair wikiPageWikiLink G_protein–coupled_receptor.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Gene_expression.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Histidine.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Hormone_response_element.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Hydrogen_bond.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Kinase.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Ligand_(biochemistry).
- Orthogonal_ligand-protein_pair wikiPageWikiLink Nuclear_receptor.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Promoter_(genetics).
- Orthogonal_ligand-protein_pair wikiPageWikiLink Receptor_(biochemistry).
- Orthogonal_ligand-protein_pair wikiPageWikiLink Receptor_activated_solely_by_a_synthetic_ligand.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Signal_transduction.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Steric_effects.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Stoma.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Substrate_(chemistry).
- Orthogonal_ligand-protein_pair wikiPageWikiLink Thyroid_hormone.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Thyroid_hormone_resistance.
- Orthogonal_ligand-protein_pair wikiPageWikiLink Triiodothyronine.
- Orthogonal_ligand-protein_pair wikiPageWikiLink File:Myowndiagram2.png.
- Orthogonal_ligand-protein_pair wikiPageUsesTemplate Template:Reflist.
- Orthogonal_ligand-protein_pair subject Category:Proteins.
- Orthogonal_ligand-protein_pair hypernym Pair.
- Orthogonal_ligand-protein_pair type Place.
- Orthogonal_ligand-protein_pair comment "Orthogonal ligand-protein pairs (also known as re-engineered ligand-receptor interfaces or re-engineered enzyme-substrate interactions) are a protein-ligand binding pair made to be independent of the original binding pair. This is done by taking a mutant protein (naturally occurring or selectively engineered), which is activated by a different ligand (carefully synthesized or selected). The intention here is that the orthogonal ligand will not interact with the original protein.".
- Orthogonal_ligand-protein_pair label "Orthogonal ligand-protein pair".
- Orthogonal_ligand-protein_pair wasDerivedFrom Orthogonal_ligand-protein_pair?oldid=694013969.
- Orthogonal_ligand-protein_pair depiction Myowndiagram2.png.
- Orthogonal_ligand-protein_pair isPrimaryTopicOf Orthogonal_ligand-protein_pair.