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- Ocfentanil abstract "Ocfentanil (INN) (also called A-3217) is a potent synthetic opioid structurally related to fentanyl that was developed in the early 1990s as one of a series of potent naloxone-reversible opioids in an attempt to obtain an opioid that had better therapeutic indices in terms of cardiovascular effects and respiratory depression as compared to fentanyl.Study of the analgesic activity of ocfentanil using the mouse hot plate test (55 °C) gave an ED50 of 0.007 mg/kg compared to 0.018 mg/kg for fentanyl; ocfentanil being approximately 2.5 times as potent as fentanyl in this test.In human volunteers ocfentanil induces effective analgesia at 1 μg/kg, while in doses up to 3 μg/kg, analgesia and respiratory depression occurred in a dose-dependent manner. While a further study suggests that ocfentanil may be as effective as morphine in post-operative relief, Ocfentanil was also studied as a supplement to general anaesthesia, in which the researchers concluded that it appears to be similar in action to fentanyl, with 3 μg/kg of ocfentanil approximately equivalent to 5 μg/kg of fentanyl.Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.".
- Ocfentanil atcPrefix "none".
- Ocfentanil casNumber "101343-69-5".
- Ocfentanil fdaUniiCode "MX52WBC8EV".
- Ocfentanil iupacName "N-(2-fluorophenyl)-2-methoxy-N-[1-(2-phenylethyl)piperidin-4-yl]acetamide".
- Ocfentanil pubchem "60575".
- Ocfentanil thumbnail Ocfentanil.png?width=300.
- Ocfentanil wikiPageID "19405876".
- Ocfentanil wikiPageLength "5776".
- Ocfentanil wikiPageOutDegree "15".
- Ocfentanil wikiPageRevisionID "701234357".
- Ocfentanil wikiPageWikiLink Analgesic.
- Ocfentanil wikiPageWikiLink Category:Acetanilides.
- Ocfentanil wikiPageWikiLink Category:Ethers.
- Ocfentanil wikiPageWikiLink Category:Fluoroarenes.
- Ocfentanil wikiPageWikiLink Category:Mu-opioid_agonists.
- Ocfentanil wikiPageWikiLink Category:Piperidines.
- Ocfentanil wikiPageWikiLink Category:Synthetic_opioids.
- Ocfentanil wikiPageWikiLink Fentanyl.
- Ocfentanil wikiPageWikiLink Hypoventilation.
- Ocfentanil wikiPageWikiLink International_nonproprietary_name.
- Ocfentanil wikiPageWikiLink Itch.
- Ocfentanil wikiPageWikiLink Nausea.
- Ocfentanil wikiPageWikiLink Opioid.
- Ocfentanil wikiPageWikiLink File:Ocfentanil_synthesis.png.
- Ocfentanil wikiPageWikiLinkText "Ocfentanil".
- Ocfentanil wikiPageWikiLinkText "Ocfentanyl".
- Ocfentanil wikiPageWikiLinkText "ocfentanil".
- Ocfentanil atcPrefix "none".
- Ocfentanil c "22".
- Ocfentanil casNumber "101343".
- Ocfentanil chemspiderid "54604".
- Ocfentanil f "1".
- Ocfentanil h "27".
- Ocfentanil inchi "1".
- Ocfentanil inchikey "NYISTOZKVCMVEL-UHFFFAOYAX".
- Ocfentanil iupacName "N--2-methoxy-N-[1-piperidin-4-yl]acetamide".
- Ocfentanil molecularWeight "370.46".
- Ocfentanil n "2".
- Ocfentanil o "2".
- Ocfentanil pubchem "60575".
- Ocfentanil smiles "COCCNC3=CC=CC=C3F".
- Ocfentanil stdinchi "1".
- Ocfentanil stdinchikey "NYISTOZKVCMVEL-UHFFFAOYSA-N".
- Ocfentanil synonyms "Ocfentanyl, A-3217".
- Ocfentanil unii "MX52WBC8EV".
- Ocfentanil verifiedfields "changed".
- Ocfentanil verifiedrevid "444480071".
- Ocfentanil width "140".
- Ocfentanil wikiPageUsesTemplate Template:Cascite.
- Ocfentanil wikiPageUsesTemplate Template:Chemspidercite.
- Ocfentanil wikiPageUsesTemplate Template:Drugbankcite.
- Ocfentanil wikiPageUsesTemplate Template:Drugbox.
- Ocfentanil wikiPageUsesTemplate Template:Fdacite.
- Ocfentanil wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Ocfentanil wikiPageUsesTemplate Template:Opioidergics.
- Ocfentanil wikiPageUsesTemplate Template:Reflist.
- Ocfentanil wikiPageUsesTemplate Template:Stdinchicite.
- Ocfentanil wikiPageUsesTemplate Template:US_patent.
- Ocfentanil subject Category:Acetanilides.
- Ocfentanil subject Category:Ethers.
- Ocfentanil subject Category:Fluoroarenes.
- Ocfentanil subject Category:Mu-opioid_agonists.
- Ocfentanil subject Category:Piperidines.
- Ocfentanil subject Category:Synthetic_opioids.
- Ocfentanil hypernym Opioid.
- Ocfentanil type ChemicalSubstance.
- Ocfentanil type Drug.
- Ocfentanil type Group.
- Ocfentanil type Agonist.
- Ocfentanil type Chemical.
- Ocfentanil type Drug.
- Ocfentanil type Ether.
- Ocfentanil type Group.
- Ocfentanil type Heterocycle.
- Ocfentanil type Opioid.
- Ocfentanil type Organofluoride.
- Ocfentanil type Organohalide.
- Ocfentanil type Organofluoride.
- Ocfentanil type Organohalide.
- Ocfentanil type ChemicalObject.
- Ocfentanil type Thing.
- Ocfentanil type Q8386.
- Ocfentanil comment "Ocfentanil (INN) (also called A-3217) is a potent synthetic opioid structurally related to fentanyl that was developed in the early 1990s as one of a series of potent naloxone-reversible opioids in an attempt to obtain an opioid that had better therapeutic indices in terms of cardiovascular effects and respiratory depression as compared to fentanyl.Study of the analgesic activity of ocfentanil using the mouse hot plate test (55 °C) gave an ED50 of 0.007 mg/kg compared to 0.018 mg/kg for fentanyl; ocfentanil being approximately 2.5 times as potent as fentanyl in this test.In human volunteers ocfentanil induces effective analgesia at 1 μg/kg, while in doses up to 3 μg/kg, analgesia and respiratory depression occurred in a dose-dependent manner. ".
- Ocfentanil label "Ocfentanil".
- Ocfentanil sameAs Q7076285.
- Ocfentanil sameAs m.04n47kz.
- Ocfentanil sameAs Okfentanil.
- Ocfentanil sameAs Okfentanil.
- Ocfentanil sameAs Q7076285.
- Ocfentanil wasDerivedFrom Ocfentanil?oldid=701234357.
- Ocfentanil depiction Ocfentanil.png.
- Ocfentanil isPrimaryTopicOf Ocfentanil.