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- NuA4_histone_acetyltransferase_complex abstract "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).Post-translational acetylation of histone H4 N-terminaltail in chromatin has been associated with severalnuclear processes including transcription. We reportthe purification and characterization of a native multi-subunit complex (NuA4) from yeast that acetylatesnucleosomal histone H4. NuA4 has an apparent molecu-lar mass of 1.3 MDa. All four conserved lysines ofhistone H4 can be acetylated by NuA4. We haveidentified the catalytic subunit of the complex as theproduct ofESA1, an essential gene required for cellcycle progression in yeast. Antibodies against Esa1pspecifically immunoprecipitate NuA4 activity whereasthe complex purified from a temperature-sensitiveesa1mutant loses its acetyltransferase activity at therestrictive temperature. Additionally, we have identi-fied another subunit of the complex as the product ofTRA1, an ATM-related essential gene homologous tohuman TRRAP, an essential cofactor for c-Myc- andE2F-mediated oncogenic transformation. Finally, theability of NuA4 to stimulate GAL4–VP16-driven tran-scription from chromatin templatesin vitrois also lostin the temperature-sensitiveesa1mutant. The functionof the essential Esa1 protein as the HAT subunit ofNuA4 and the presence of Tra1p, a putative [[transcrip-tion]] activator-interacting subunit, supports an essentiallink between nuclear H4 acetylation, transcriptionalregulation and cell cycle control.".
- NuA4_histone_acetyltransferase_complex symbol "NuA4".
- NuA4_histone_acetyltransferase_complex wikiPageID "43774161".
- NuA4_histone_acetyltransferase_complex wikiPageLength "2440".
- NuA4_histone_acetyltransferase_complex wikiPageOutDegree "21".
- NuA4_histone_acetyltransferase_complex wikiPageRevisionID "670626103".
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink ATPase.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink Acetylation.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink BUVBL2.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink Category:Protein_complexes.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink Chromatin.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink DNA.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink Helicase.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink Histone.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink Human.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink Lysines.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink Protein.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink RuvB-like_1.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink Structure.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink Transcrip-.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink Transcription_(genetics).
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink transcription_domain-associated_protein.
- NuA4_histone_acetyltransferase_complex wikiPageWikiLink Yeast.
- NuA4_histone_acetyltransferase_complex interpro "IPR015418".
- NuA4_histone_acetyltransferase_complex pfam "PF09340".
- NuA4_histone_acetyltransferase_complex symbol "NuA4".
- NuA4_histone_acetyltransferase_complex wikiPageUsesTemplate Template:Context.
- NuA4_histone_acetyltransferase_complex wikiPageUsesTemplate Template:Multiple_issues.
- NuA4_histone_acetyltransferase_complex wikiPageUsesTemplate Template:Orphan.
- NuA4_histone_acetyltransferase_complex wikiPageUsesTemplate Template:PDB3.
- NuA4_histone_acetyltransferase_complex wikiPageUsesTemplate Template:Pfam_box.
- NuA4_histone_acetyltransferase_complex wikiPageUsesTemplate Template:Reflist.
- NuA4_histone_acetyltransferase_complex subject Category:Protein_complexes.
- NuA4_histone_acetyltransferase_complex type Biomolecule.
- NuA4_histone_acetyltransferase_complex type Protein.
- NuA4_histone_acetyltransferase_complex type Thing.
- NuA4_histone_acetyltransferase_complex type Q206229.
- NuA4_histone_acetyltransferase_complex type Q8054.
- NuA4_histone_acetyltransferase_complex comment "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A.".
- NuA4_histone_acetyltransferase_complex label "NuA4 histone acetyltransferase complex".
- NuA4_histone_acetyltransferase_complex sameAs Q18355286.
- NuA4_histone_acetyltransferase_complex sameAs m.011sq9jd.
- NuA4_histone_acetyltransferase_complex sameAs Q18355286.
- NuA4_histone_acetyltransferase_complex wasDerivedFrom NuA4_histone_acetyltransferase_complex?oldid=670626103.
- NuA4_histone_acetyltransferase_complex isPrimaryTopicOf NuA4_histone_acetyltransferase_complex.