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- Non-peptidic_antigen abstract "Non-peptidic antigens are low-molecular-weight compounds that stimulate human Vγ9/Vδ2 T cells. The most potent activator for Vγ9/Vδ2 T cells is (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), a natural intermediate of the non-mevalonate pathway of isopentenyl pyrophosphate (IPP) biosynthesis. HMB-PP is an essential metabolite in most pathogenic bacteria including Mycobacterium tuberculosis as well as in malaria parasites, but is absent from the human host. IPP itself is structurally closely related to HMB-PP and ubiquitously present in all living cells (i.e., also in human cells), yet its potency in vitro is 10,000-fold reduced; whether IPP represents a physiological 'danger' signal of stressed or transformed cells is still unclear. Of pharmacological interest and with bioactivities comparable to that of IPP are synthetic aminobisphosphonates such as zoledronate (Zometa) that are widely used to treat osteoporosis and bone metastases, and act as Vγ9/Vδ2 T cell receptor agonists. Certain alkylated amines have been described to activate Vγ9/Vδ2 T cells in vitro, however only at millimolar concentrations, i.e., with potencies 106-fold to 108-fold lower than those of HMB-PP, thereby questioning their physiological relevance.".
- Non-peptidic_antigen wikiPageID "8439438".
- Non-peptidic_antigen wikiPageLength "2134".
- Non-peptidic_antigen wikiPageOutDegree "16".
- Non-peptidic_antigen wikiPageRevisionID "632450910".
- Non-peptidic_antigen wikiPageWikiLink (E)-4-Hydroxy-3-methyl-but-2-enyl_pyrophosphate.
- Non-peptidic_antigen wikiPageWikiLink Amine.
- Non-peptidic_antigen wikiPageWikiLink Bisphosphonate.
- Non-peptidic_antigen wikiPageWikiLink Category:Immune_system.
- Non-peptidic_antigen wikiPageWikiLink Category:T_cells.
- Non-peptidic_antigen wikiPageWikiLink Gamma_delta_T_cell.
- Non-peptidic_antigen wikiPageWikiLink Isopentenyl_pyrophosphate.
- Non-peptidic_antigen wikiPageWikiLink Malaria.
- Non-peptidic_antigen wikiPageWikiLink Metastasis.
- Non-peptidic_antigen wikiPageWikiLink Mycobacterium_tuberculosis.
- Non-peptidic_antigen wikiPageWikiLink Non-mevalonate_pathway.
- Non-peptidic_antigen wikiPageWikiLink Osteoporosis.
- Non-peptidic_antigen wikiPageWikiLink Zoledronic_acid.
- Non-peptidic_antigen wikiPageWikiLinkText "IPP or alkyl amines".
- Non-peptidic_antigen wikiPageWikiLinkText "Non-peptidic antigen".
- Non-peptidic_antigen wikiPageWikiLinkText "common molecules".
- Non-peptidic_antigen wikiPageWikiLinkText "non-peptidic antigen".
- Non-peptidic_antigen wikiPageUsesTemplate Template:DOI.
- Non-peptidic_antigen subject Category:Immune_system.
- Non-peptidic_antigen subject Category:T_cells.
- Non-peptidic_antigen hypernym Compounds.
- Non-peptidic_antigen type ChemicalCompound.
- Non-peptidic_antigen type Cell.
- Non-peptidic_antigen comment "Non-peptidic antigens are low-molecular-weight compounds that stimulate human Vγ9/Vδ2 T cells. The most potent activator for Vγ9/Vδ2 T cells is (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), a natural intermediate of the non-mevalonate pathway of isopentenyl pyrophosphate (IPP) biosynthesis. HMB-PP is an essential metabolite in most pathogenic bacteria including Mycobacterium tuberculosis as well as in malaria parasites, but is absent from the human host.".
- Non-peptidic_antigen label "Non-peptidic antigen".
- Non-peptidic_antigen sameAs Q7048974.
- Non-peptidic_antigen sameAs m.0273gt3.
- Non-peptidic_antigen sameAs Q7048974.
- Non-peptidic_antigen wasDerivedFrom Non-peptidic_antigen?oldid=632450910.
- Non-peptidic_antigen isPrimaryTopicOf Non-peptidic_antigen.