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- Nitrotyrosine abstract "Nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide. Nitrotyrosine is identified as an indicator or marker of cell damage, inflammation as well as NO (nitric oxide) production. Nitrotyrosine is formed in the presence of the active metabolite NO. Generally in many disease states, oxidative stress increases the production of superoxide (O2−) and NO forming peroxynitrite (ONOO−) a destructive free radical oxidant The production of ONOO− is capable of oxidizing several lipoproteins and of nitrating tyrosine residues in many proteins. It is difficult to determine the production of ONOO− so, usually nitrotyrosine in proteins are the detectable marker for indirectly detecting ONOO−. It is detected in large number of pathological conditions and is considered a marker of NO-dependent, reactive nitrogen species-induced nitrative stress. Nitrotyrosine is detected in biological fluids such as plasma, lung aspirants-BALF (Broncho alveolar lining fluid and urine. Increased level of nitrotyrosine is detected in rheumatoid arthritis septic shock and coeliac disease. In all these studies nitrotyrosine was undetected in healthy subjects. Nitrotyrosine is also found in numerous other disease-affected tissues, such as the cornea in keratoconus. Peroxynitrite and/or nitrative stress may participate in the pathogenesis of diabetesResearch shows that nitrotyrosine levels can be reduced by N-acetyl cysteine, which is a precursor to glutathione, one of the body's primary endogenous antioxidants. Nitrotyrosine levels have been linked to cerebral ischemia and edema, for which NAC has also been proven as a potential treatment.Free nitrotyrosine undergoes metabolism to form 3-nitro-4-hydroxyphenylacetic acid (NHPA) which is excreted in the urine.".
- Nitrotyrosine iupacName "(2S)-2-Amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid".
- Nitrotyrosine thumbnail Nitrotyrosine.png?width=300.
- Nitrotyrosine wikiPageID "22591237".
- Nitrotyrosine wikiPageLength "7951".
- Nitrotyrosine wikiPageOutDegree "12".
- Nitrotyrosine wikiPageRevisionID "704095317".
- Nitrotyrosine wikiPageWikiLink Acetylcysteine.
- Nitrotyrosine wikiPageWikiLink Category:Amino_acids.
- Nitrotyrosine wikiPageWikiLink Category:Nitro_compounds.
- Nitrotyrosine wikiPageWikiLink Cornea.
- Nitrotyrosine wikiPageWikiLink Diabetes_mellitus.
- Nitrotyrosine wikiPageWikiLink Glutathione.
- Nitrotyrosine wikiPageWikiLink Keratoconus.
- Nitrotyrosine wikiPageWikiLink Nitration.
- Nitrotyrosine wikiPageWikiLink Nitrogen_dioxide.
- Nitrotyrosine wikiPageWikiLink Peroxynitrite.
- Nitrotyrosine wikiPageWikiLink Reactive_nitrogen_species.
- Nitrotyrosine wikiPageWikiLink Tyrosine.
- Nitrotyrosine wikiPageWikiLinkText "Nitrotyrosine".
- Nitrotyrosine imagefile "nitrotyrosine.png".
- Nitrotyrosine iupacname "-2".
- Nitrotyrosine othernames "3".
- Nitrotyrosine verifiedrevid "444028237".
- Nitrotyrosine watchedfields "changed".
- Nitrotyrosine wikiPageUsesTemplate Template:Biochem-stub.
- Nitrotyrosine wikiPageUsesTemplate Template:Cascite.
- Nitrotyrosine wikiPageUsesTemplate Template:Chembox.
- Nitrotyrosine wikiPageUsesTemplate Template:Chembox_Hazards.
- Nitrotyrosine wikiPageUsesTemplate Template:Chembox_Identifiers.
- Nitrotyrosine wikiPageUsesTemplate Template:Chembox_Properties.
- Nitrotyrosine wikiPageUsesTemplate Template:Chemspidercite.
- Nitrotyrosine wikiPageUsesTemplate Template:Drugbankcite.
- Nitrotyrosine wikiPageUsesTemplate Template:Ebicite.
- Nitrotyrosine wikiPageUsesTemplate Template:Reflist.
- Nitrotyrosine wikiPageUsesTemplate Template:Stdinchicite.
- Nitrotyrosine subject Category:Amino_acids.
- Nitrotyrosine subject Category:Nitro_compounds.
- Nitrotyrosine hypernym Product.
- Nitrotyrosine type Biomolecule.
- Nitrotyrosine type ChemicalCompound.
- Nitrotyrosine type ChemicalSubstance.
- Nitrotyrosine type Software.
- Nitrotyrosine type Biomolecule.
- Nitrotyrosine type ChemicalObject.
- Nitrotyrosine type Thing.
- Nitrotyrosine type Q11173.
- Nitrotyrosine comment "Nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide. Nitrotyrosine is identified as an indicator or marker of cell damage, inflammation as well as NO (nitric oxide) production. Nitrotyrosine is formed in the presence of the active metabolite NO.".
- Nitrotyrosine label "Nitrotyrosine".
- Nitrotyrosine sameAs Q412383.
- Nitrotyrosine sameAs Nitrotyrosin.
- Nitrotyrosine sameAs Nitrotirosina.
- Nitrotyrosine sameAs نیتروتیوزین.
- Nitrotyrosine sameAs m.05zzwm_.
- Nitrotyrosine sameAs Нитротирозин.
- Nitrotyrosine sameAs Nitrotirosin.
- Nitrotyrosine sameAs Nitrotirosin.
- Nitrotyrosine sameAs Q412383.
- Nitrotyrosine wasDerivedFrom Nitrotyrosine?oldid=704095317.
- Nitrotyrosine depiction Nitrotyrosine.png.
- Nitrotyrosine isPrimaryTopicOf Nitrotyrosine.