DBpedia 2016-04

Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Nitrosoprodenafil> ?p ?o }

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Nitrosoprodenafil abstract "Nitrosoprodenafil is a synthetic designer drug found in \"herbal\" aphrodisiac products, which is a novel nitrosated analogue of sildenafil (Viagra). It has an innovative structure which acts as a prodrug, breaking down in the body to release both the PDE5 inhibitor aildenafil as well as free nitric oxide, which have powerfully synergistic effects. This dual mechanism of action has never been exploited by conventional pharmaceutical companies because of the risks involved; usually combining PDE5 inhibitors with nitric oxide releasers like amyl nitrite is contraindicated as it can cause a precipitous drop in blood pressure that can potentially result in death. Nitrosamines are also generally avoided in drug development as they can often be hepatotoxic, so while the combined mechanisms of action are likely to be effective, this drug also has severe risks of toxicity.Shortly after Venhuis et al. published the suggested structure for nitrosoprodenafil it was contested by Demizu et al. who suggested the structure was an azathioprine / aildenafil hybrid. This newly suggested structure was dubbed 'mutaprodenafil' because of the structural similarity with the mutagenic azathioprine. The final confirmation of the azathioprine / aildenafil hybrid was provided by Sakamoto et al. who prepared crystals for X-ray analysis. Although Sakamoto et al. support the name 'mutaprodenafil' they prefer to use 'nitroprodenafil' instead.".
Nitrosoprodenafil atcPrefix "none".
Nitrosoprodenafil casNumber "1266755-08-1".
Nitrosoprodenafil fdaUniiCode "X8TO9P16G7".
Nitrosoprodenafil iupacName "2-[(5-[5-(3,5-dimethylpiperazine-1-sulfonyl)-2-ethoxyphenyl]-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)oxy]-N-methyl-N-nitroso-1,3-thiazol-5-amine".
Nitrosoprodenafil thumbnail Nitrosoprodenafil_structure.png?width=300.
Nitrosoprodenafil wikiPageID "34062605".
Nitrosoprodenafil wikiPageLength "4919".
Nitrosoprodenafil wikiPageOutDegree "25".
Nitrosoprodenafil wikiPageRevisionID "671901882".
Nitrosoprodenafil wikiPageWikiLink Acetildenafil.
Nitrosoprodenafil wikiPageWikiLink Aildenafil.
Nitrosoprodenafil wikiPageWikiLink Amyl_nitrite.
Nitrosoprodenafil wikiPageWikiLink Aphrodisiac.
Nitrosoprodenafil wikiPageWikiLink CGMP-specific_phosphodiesterase_type_5.
Nitrosoprodenafil wikiPageWikiLink Category:Designer_drugs.
Nitrosoprodenafil wikiPageWikiLink Category:Ketones.
Nitrosoprodenafil wikiPageWikiLink Category:Nitro_compounds.
Nitrosoprodenafil wikiPageWikiLink Category:PDE5_inhibitors.
Nitrosoprodenafil wikiPageWikiLink Category:Phenol_ethers.
Nitrosoprodenafil wikiPageWikiLink Category:Piperazines.
Nitrosoprodenafil wikiPageWikiLink Category:Pyrazolopyrimidines.
Nitrosoprodenafil wikiPageWikiLink Category:Thiazoles.
Nitrosoprodenafil wikiPageWikiLink Designer_drug.
Nitrosoprodenafil wikiPageWikiLink Hepatotoxicity.
Nitrosoprodenafil wikiPageWikiLink Naproxcinod.
Nitrosoprodenafil wikiPageWikiLink Nitric_oxide.
Nitrosoprodenafil wikiPageWikiLink Nitrosamine.
Nitrosoprodenafil wikiPageWikiLink PDE5_inhibitor.
Nitrosoprodenafil wikiPageWikiLink Prodrug.
Nitrosoprodenafil wikiPageWikiLink Sildenafil.
Nitrosoprodenafil wikiPageWikiLink Structural_analog.
Nitrosoprodenafil wikiPageWikiLink Sulfoaildenafil.
Nitrosoprodenafil wikiPageWikiLink File:Nitrosoprodenafil_ambiguity.png.
Nitrosoprodenafil wikiPageWikiLinkText "Nitrosoprodenafil".
Nitrosoprodenafil wikiPageWikiLinkText "nitrosoprodenafil".
Nitrosoprodenafil atcPrefix "none".
Nitrosoprodenafil c "28".
Nitrosoprodenafil casNumber "1266755".
Nitrosoprodenafil chemspiderid "32701496".
Nitrosoprodenafil h "38".
Nitrosoprodenafil inchi "1".
Nitrosoprodenafil inchikey "DTAKXJYYAUWRND-CALCHBBNBM".
Nitrosoprodenafil iupacName "2".
Nitrosoprodenafil legalUs "OTC".
Nitrosoprodenafil molecularWeight "630.78".
Nitrosoprodenafil n "8".
Nitrosoprodenafil o "5".
Nitrosoprodenafil s "2".
Nitrosoprodenafil smiles "CCCc1c2cnC".
Nitrosoprodenafil stdinchi "1".
Nitrosoprodenafil stdinchikey "DTAKXJYYAUWRND-CALCHBBNSA-N".
Nitrosoprodenafil unii "X8TO9P16G7".
Nitrosoprodenafil width "250".
Nitrosoprodenafil wikiPageUsesTemplate Template:Clear_left.
Nitrosoprodenafil wikiPageUsesTemplate Template:Drugbankcite.
Nitrosoprodenafil wikiPageUsesTemplate Template:Drugbox.
Nitrosoprodenafil wikiPageUsesTemplate Template:Fdacite.
Nitrosoprodenafil wikiPageUsesTemplate Template:Phosphodiesterase_inhibitors.
Nitrosoprodenafil wikiPageUsesTemplate Template:Reflist.
Nitrosoprodenafil subject Category:Designer_drugs.
Nitrosoprodenafil subject Category:Ketones.
Nitrosoprodenafil subject Category:Nitro_compounds.
Nitrosoprodenafil subject Category:PDE5_inhibitors.
Nitrosoprodenafil subject Category:Phenol_ethers.
Nitrosoprodenafil subject Category:Piperazines.
Nitrosoprodenafil subject Category:Pyrazolopyrimidines.
Nitrosoprodenafil subject Category:Thiazoles.
Nitrosoprodenafil hypernym Drug.
Nitrosoprodenafil type ChemicalSubstance.
Nitrosoprodenafil type Drug.
Nitrosoprodenafil type Group.
Nitrosoprodenafil type Chemical.
Nitrosoprodenafil type Drug.
Nitrosoprodenafil type Ether.
Nitrosoprodenafil type Group.
Nitrosoprodenafil type Heterocycle.
Nitrosoprodenafil type Inhibitor.
Nitrosoprodenafil type Ketone.
Nitrosoprodenafil type Vasodilator.
Nitrosoprodenafil type ChemicalObject.
Nitrosoprodenafil type Thing.
Nitrosoprodenafil type Q8386.
Nitrosoprodenafil comment "Nitrosoprodenafil is a synthetic designer drug found in \"herbal\" aphrodisiac products, which is a novel nitrosated analogue of sildenafil (Viagra). It has an innovative structure which acts as a prodrug, breaking down in the body to release both the PDE5 inhibitor aildenafil as well as free nitric oxide, which have powerfully synergistic effects.".
Nitrosoprodenafil label "Nitrosoprodenafil".
Nitrosoprodenafil sameAs Q7041506.
Nitrosoprodenafil sameAs m.0hrg8bz.
Nitrosoprodenafil sameAs Nitrozoprodenafil.
Nitrosoprodenafil sameAs Nitrozoprodenafil.
Nitrosoprodenafil sameAs Q7041506.
Nitrosoprodenafil wasDerivedFrom Nitrosoprodenafil?oldid=671901882.
Nitrosoprodenafil depiction Nitrosoprodenafil_structure.png.
Nitrosoprodenafil isPrimaryTopicOf Nitrosoprodenafil.