Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Naloxegol> ?p ?o }
- Naloxegol abstract "Naloxegol (INN; PEGylated naloxol; trade names Movantik and Moventig) is a peripherally-selective opioid antagonist developed by AstraZeneca, licensed from Nektar, for the treatment of opioid-induced constipation. It was approved in 2014 in adult patients with chronic, non-cancer pain. Doses of 25 mg were found safe and well tolerated for 52 weeks. When given concomitantly with opioid analgesics, naloxegol reduced constipation-related side effects, while maintaining comparable levels of analgesia.Chemically, naloxegol is a pegylated (polyethylene glycol-modified) derivative of α-naloxol. Specifically, the 5-α-hydroxyl group of α-naloxol is connected via an ether linkage to the free hydroxyl group of a monomethoxy-terminated n=7 oligomer of PEG, shown extending at the lower left of the molecule image at right. The \"n=7\" defines the number of two-carbon ethylenes, and so the chain length, of the attached PEG chain, and the \"monomethoxy\" indicates that the terminal hydroxyl group of the PEG is \"capped\" with a methyl group. The pegylation of the 5-α-hydroxyl side chain of naloxol prevents the drug from crossing the blood-brain barrier (BBB). As such, it can be considered the antithesis of the peripherally-acting opiate loperamide which is utilized as an opiate-targeting anti-diarrheal agent that does not cause traditional opiate side-effects due to its inability to accumulate in the central nervous system in normal subjects. Naloxegol was previously a Schedule II drug in the United States because of its chemical similarity to opium alkaloids, but was recently reclassified as a prescription drug after the FDA concluded that the impermeability of the blood-brain barrier to this compound made it non-habit-forming, and so without the potential for abuse -- specifically, naloxegol was officially decontrolled on 23. January 2015. As an opiate antagonist, it is not expected to be capable of inducing the euphoria and anxiolytic effects which are generally cited as the desirable effects of commonly abused opiates (all of which are opiate agonists) if it were to cross the BBB; it would in fact reverse the effects of opiate drugs of abuse if it entered the central nervous system.".
- Naloxegol atcPrefix "A06".
- Naloxegol atcSuffix "AH03".
- Naloxegol casNumber "854601-70-0".
- Naloxegol chEBI "82975".
- Naloxegol iupacName "(5α,6α)-4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)morphinan-3,14-diol".
- Naloxegol pubchem "56959087".
- Naloxegol thumbnail Naloxegol.svg?width=300.
- Naloxegol wikiPageID "35824434".
- Naloxegol wikiPageLength "7492".
- Naloxegol wikiPageOutDegree "37".
- Naloxegol wikiPageRevisionID "707175006".
- Naloxegol wikiPageWikiLink Alvimopan.
- Naloxegol wikiPageWikiLink Anxiolytic.
- Naloxegol wikiPageWikiLink AstraZeneca.
- Naloxegol wikiPageWikiLink Binding_selectivity.
- Naloxegol wikiPageWikiLink Blood–brain_barrier.
- Naloxegol wikiPageWikiLink CYP3A.
- Naloxegol wikiPageWikiLink Category:Alkenes.
- Naloxegol wikiPageWikiLink Category:Diols.
- Naloxegol wikiPageWikiLink Category:Morphinans.
- Naloxegol wikiPageWikiLink Category:Opioid_antagonists.
- Naloxegol wikiPageWikiLink Category:Peripherally_selective_drugs.
- Naloxegol wikiPageWikiLink Category:Synthetic_opioids.
- Naloxegol wikiPageWikiLink Constipation.
- Naloxegol wikiPageWikiLink Controlled_Substances_Act.
- Naloxegol wikiPageWikiLink Derivative_(chemistry).
- Naloxegol wikiPageWikiLink Ether.
- Naloxegol wikiPageWikiLink Euphoria.
- Naloxegol wikiPageWikiLink Hydroxyl.
- Naloxegol wikiPageWikiLink International_nonproprietary_name.
- Naloxegol wikiPageWikiLink Loperamide.
- Naloxegol wikiPageWikiLink Methyl_group.
- Naloxegol wikiPageWikiLink Naldemedine.
- Naloxegol wikiPageWikiLink Naloxol.
- Naloxegol wikiPageWikiLink Oligomer.
- Naloxegol wikiPageWikiLink Opioid.
- Naloxegol wikiPageWikiLink Opioid_antagonist.
- Naloxegol wikiPageWikiLink Oral_administration.
- Naloxegol wikiPageWikiLink PEGylation.
- Naloxegol wikiPageWikiLink Peripheral_nervous_system.
- Naloxegol wikiPageWikiLink Polyethylene_glycol.
- Naloxegol wikiPageWikiLink Prescription_drug.
- Naloxegol wikiPageWikiLink Semipermeable_membrane.
- Naloxegol wikiPageWikiLink Substance_abuse.
- Naloxegol wikiPageWikiLinkText "Naloxegol".
- Naloxegol wikiPageWikiLinkText "naloxegol".
- Naloxegol atcPrefix "A06".
- Naloxegol atcSuffix "AH03".
- Naloxegol c "34".
- Naloxegol casNumber "854601".
- Naloxegol chebi "82975".
- Naloxegol chemspiderid "28651656".
- Naloxegol eliminationHalfLife "-39600.0".
- Naloxegol excretion "Feces , urine".
- Naloxegol h "53".
- Naloxegol inchi "1".
- Naloxegol inchikey "XNKCCCKFOQNXKV-ZRSCBOBOBQ".
- Naloxegol iupacName "-45".
- Naloxegol legalUs "Unscheduled".
- Naloxegol licenceUs "Movantik".
- Naloxegol metabolism "Hepatic".
- Naloxegol molecularWeight "651.785".
- Naloxegol n "1".
- Naloxegol o "11".
- Naloxegol pregnancyUs "C".
- Naloxegol proteinBound "~4.2%".
- Naloxegol pubchem "56959087".
- Naloxegol routesOfAdministration Oral_administration.
- Naloxegol smiles "COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@]2O".
- Naloxegol stdinchi "1".
- Naloxegol stdinchikey "XNKCCCKFOQNXKV-ZRSCBOBOSA-N".
- Naloxegol synonyms "NKTR-118".
- Naloxegol tradename "Movantik, Moventig".
- Naloxegol wikiPageUsesTemplate Template:Drugbox.
- Naloxegol wikiPageUsesTemplate Template:Drugs.com.
- Naloxegol wikiPageUsesTemplate Template:Laxatives.
- Naloxegol wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Naloxegol wikiPageUsesTemplate Template:Opioidergics.
- Naloxegol wikiPageUsesTemplate Template:Reflist.
- Naloxegol subject Category:Alkenes.
- Naloxegol subject Category:Diols.
- Naloxegol subject Category:Morphinans.
- Naloxegol subject Category:Opioid_antagonists.
- Naloxegol subject Category:Peripherally_selective_drugs.
- Naloxegol subject Category:Synthetic_opioids.
- Naloxegol hypernym Antagonist.
- Naloxegol type ChemicalSubstance.
- Naloxegol type Drug.
- Naloxegol type Alcohol.
- Naloxegol type Alkene.
- Naloxegol type Antagonist.
- Naloxegol type Chemical.
- Naloxegol type Drug.
- Naloxegol type Heterocycle.
- Naloxegol type Hydrocarbon.
- Naloxegol type Opioid.
- Naloxegol type Polyol.
- Naloxegol type ChemicalObject.
- Naloxegol type Thing.