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- Mothers_curse abstract "In biology, mother's curse is an evolutionary effect that males inherit deleterious mitochondrial genome (mtDNA) mutations from their mother, while those mutations are beneficial, neutral or less deleterious to females.As mtDNA is usually maternally inherited, mtDNA mutations deleterious to males but beneficial, neutral or less deleterious to females are not subjected to be selected against, which results in a sex-biased selective sieve. Therefore, male-specific deleterious mtDNA mutations could be maintained and reach a high frequency in populations, decreasing males' fitness and population viability. In addition, the effect of mtDNA mutations on fitness has a threshold effect, i.e. only when the number of mutation reaches the threshold, mtDNA mutations will decrease individual fitness.Males are more susceptible to mtDNA defects, not only because of lack of selection for mtDNA on males but also due to sperm’s higher energy requirements for motility. There are evidence showing mtDNA mutations are more likely to affect males. In humans, Leber's hereditary optic neuropathy (LHON) is caused by one or several point mutations on mtDNA and LHON affects more males than females. In mice, a deletion on mtDNA causes oligospermia and asthenozoospermia, resulting in infertility. Taken together, mtDNA mutations pose a greater threat on males than on females.".
- Mothers_curse thumbnail Mother_curse.png?width=300.
- Mothers_curse wikiPageID "48786616".
- Mothers_curse wikiPageLength "7363".
- Mothers_curse wikiPageOutDegree "15".
- Mothers_curse wikiPageRevisionID "696052366".
- Mothers_curse wikiPageWikiLink Assortative_mating.
- Mothers_curse wikiPageWikiLink Category:Evolutionary_biology.
- Mothers_curse wikiPageWikiLink Category:Mitochondria.
- Mothers_curse wikiPageWikiLink Coevolution.
- Mothers_curse wikiPageWikiLink Cytoplasmic_male_sterility.
- Mothers_curse wikiPageWikiLink Fitness_(biology).
- Mothers_curse wikiPageWikiLink Genetic_load.
- Mothers_curse wikiPageWikiLink Kin_selection.
- Mothers_curse wikiPageWikiLink Lebers_hereditary_optic_neuropathy.
- Mothers_curse wikiPageWikiLink Mitochondrion.
- Mothers_curse wikiPageWikiLink Mutation.
- Mothers_curse wikiPageWikiLink Paternal_mtDNA_transmission.
- Mothers_curse wikiPageWikiLink Population.
- Mothers_curse wikiPageWikiLink Sexual_conflict.
- Mothers_curse wikiPageWikiLink File:Mother_curse.png.
- Mothers_curse wikiPageWikiLinkText "Mother's curse".
- Mothers_curse wikiPageUsesTemplate Template:Reflist.
- Mothers_curse subject Category:Evolutionary_biology.
- Mothers_curse subject Category:Mitochondria.
- Mothers_curse hypernym Effect.
- Mothers_curse type Disease.
- Mothers_curse comment "In biology, mother's curse is an evolutionary effect that males inherit deleterious mitochondrial genome (mtDNA) mutations from their mother, while those mutations are beneficial, neutral or less deleterious to females.As mtDNA is usually maternally inherited, mtDNA mutations deleterious to males but beneficial, neutral or less deleterious to females are not subjected to be selected against, which results in a sex-biased selective sieve.".
- Mothers_curse label "Mother's curse".
- Mothers_curse wasDerivedFrom Mothers_curse?oldid=696052366.
- Mothers_curse depiction Mother_curse.png.
- Mothers_curse isPrimaryTopicOf Mothers_curse.