Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Microsome> ?p ?o }
Showing triples 1 to 56 of
56
with 100 triples per page.
- Microsome abstract "In cell biology, microsomes are vesicle-like artifacts re-formed from pieces of the endoplasmic reticulum (ER) when eukaryotic cells are broken-up in the laboratory; microsomes are not present in healthy, living cells.Microsomes can be concentrated and separated from other cellular debris by differential centrifugation. Unbroken cells, nuclei, and mitochondria sediment out at 10,000g, whereas soluble enzymes and fragmented ER, which contains cytochrome P450 (CYP), remain in solution (g is the Earth's gravitational acceleration). At 100,000g, achieved by faster centrifuge rotation, ER sediments out of solution as a pellet but the soluble enzymes remain in the supernatant. In this way, cytochrome P450 in microsomes is concentrated and isolated. Microsomes have a reddish brown color, due to the presence of the heme. Because of the need for a multi-part protein-system, microsomes are necessary to analyze the metabolic activity of CYPs. They are highly abundant in livers of rats, mice and humans, but present in all other organs and organisms as well. To get microsomes containing a specific CYP or for high amounts of active enzyme, microsomes are prepared from E.coli or Sf9 insect cells via heterologous expression. Therefore, microsomes are a valuable tool for investigating the metabolism of compounds (enzyme inhibition, clearance and metabolite identification) and for examining drug-drug interactions by in vitro-research. Researchers often select microsome lots based on the enzyme activity level of specific CYPs. Some lots are available to study specific populations (example: lung microsomes from smokers or non-smokers) or divided into classifications to meet target CYP activity levels for inhibition and metabolism studies. Researchers use microsomes to mimic the activity of the endoplasmic reticulum in a test tube and conduct experiments that require protein synthesis on a membrane; they provide a way for scientists to figure out how proteins are being made on the ER in a cell by reconstituting the process in a test tube.".
- Microsome wikiPageExternalLink microsomal-stability.
- Microsome wikiPageExternalLink 233425223_Studies_on_liver_microsomal_fraction?ev=prf_pub.
- Microsome wikiPageID "912128".
- Microsome wikiPageLength "3367".
- Microsome wikiPageOutDegree "19".
- Microsome wikiPageRevisionID "692366460".
- Microsome wikiPageWikiLink Anti-thyroid_autoantibodies.
- Microsome wikiPageWikiLink Category:Membrane_biology.
- Microsome wikiPageWikiLink Cell_biology.
- Microsome wikiPageWikiLink Cell_nucleus.
- Microsome wikiPageWikiLink Cytochrome_P450.
- Microsome wikiPageWikiLink Differential_centrifugation.
- Microsome wikiPageWikiLink Endoplasmic_reticulum.
- Microsome wikiPageWikiLink Escherichia_coli.
- Microsome wikiPageWikiLink Eukaryote.
- Microsome wikiPageWikiLink Heme.
- Microsome wikiPageWikiLink In_vitro.
- Microsome wikiPageWikiLink Metabolite.
- Microsome wikiPageWikiLink Mitochondrion.
- Microsome wikiPageWikiLink Precipitation_(chemistry).
- Microsome wikiPageWikiLink S9_fraction.
- Microsome wikiPageWikiLink Sf9.
- Microsome wikiPageWikiLink Vesicle_(biology_and_chemistry).
- Microsome wikiPageWikiLinkText "Microsome".
- Microsome wikiPageWikiLinkText "microsomal enzyme system".
- Microsome wikiPageWikiLinkText "microsomal".
- Microsome wikiPageWikiLinkText "microsome".
- Microsome wikiPageUsesTemplate Template:Biochemistry-stub.
- Microsome wikiPageUsesTemplate Template:Cell-biology-stub.
- Microsome wikiPageUsesTemplate Template:MeshNumber.
- Microsome wikiPageUsesTemplate Template:Organelles.
- Microsome wikiPageUsesTemplate Template:Reflist.
- Microsome subject Category:Membrane_biology.
- Microsome hypernym Artifacts.
- Microsome type Biophysic.
- Microsome comment "In cell biology, microsomes are vesicle-like artifacts re-formed from pieces of the endoplasmic reticulum (ER) when eukaryotic cells are broken-up in the laboratory; microsomes are not present in healthy, living cells.Microsomes can be concentrated and separated from other cellular debris by differential centrifugation.".
- Microsome label "Microsome".
- Microsome sameAs Q547502.
- Microsome sameAs Mikrosom.
- Microsome sameAs Microsoma.
- Microsome sameAs Microsome.
- Microsome sameAs Microsoma.
- Microsome sameAs Mikrosom.
- Microsome sameAs Միկրոսոմներ.
- Microsome sameAs Mikrosomo.
- Microsome sameAs Microsoma.
- Microsome sameAs Mikrosom.
- Microsome sameAs m.03p6mh.
- Microsome sameAs Mikrozom.
- Microsome sameAs Mikrozom.
- Microsome sameAs Mikrozom.
- Microsome sameAs Q547502.
- Microsome sameAs 微粒體.
- Microsome wasDerivedFrom Microsome?oldid=692366460.
- Microsome isPrimaryTopicOf Microsome.