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- Methylselenocysteine abstract "Methylselenocysteine, also known as Se-methylselenocysteine, is an analog of S-methylcysteine in which the sulfur atom is replaced with a selenium atom. It is an inhibitor of DMBA-induced mammary tumorsand a \"chemopreventive agent that blocks cell cycle progression and proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture.\"Apoptosis has been proposed as the most plausible mechanism for the chemopreventive activities of selenocompounds. Se-Methylselenocysteine was more efficient at inducing apoptosis than selenite, but was less toxic.\"The \"selenite-induced cell death could be derived from necrosis rather than apoptosis, since selenite did not significantly induce several apoptotic phenomena, including the activation of caspase-3.\"In the Nutritional Prevention of Cancer Trial, selenized yeast resulted in \"a reduction in the incidence of prostate cancer and in total cancer incidence\"; subsequent anti-cancer studies using selenomethionine did not show any benefit against cancer; but, selenized yeast contains both selenomethionine and methylselenocysteine.Methylselenocysteine is found in selenized yeast, and many vegetables: \"As much as 80% of the total selenium\" found in Alliums (onion, leek, garlic, ramps) Brassicas (broccoli, radish, Brussels sprouts, cabbage), and milk vetch (Astragalus spp, Fabaceae) \"is present as Se-methylselenocysteine.\" The bioavailability of selenium from Se methylselenocysteine, \"is likely to be similar to that from other organic selenium compounds.\" Specifically, \"It is converted via the action of β-lyase, to methylselenol and then to hydrogen selenide, which is also the key metabolite derived from\" all other common forms of selenium. But EFSA concluded that \"given the absence of human studies on Se-methylselenocysteine, the relatively sparse database on the bioavailability of selenium from this source and the limited data on the safety of this source compared with other selenium compounds, the Upper Limit for selenium defined by the Scientific Committee on Food cannot be used for judging its safety.\"".
- Methylselenocysteine thumbnail Methylselenocysteine.svg?width=300.
- Methylselenocysteine wikiPageID "46592333".
- Methylselenocysteine wikiPageLength "5088".
- Methylselenocysteine wikiPageOutDegree "21".
- Methylselenocysteine wikiPageRevisionID "704264785".
- Methylselenocysteine wikiPageWikiLink 7,12-Dimethylbenz(a)anthracene.
- Methylselenocysteine wikiPageWikiLink Allium.
- Methylselenocysteine wikiPageWikiLink Apoptosis.
- Methylselenocysteine wikiPageWikiLink Astragalus.
- Methylselenocysteine wikiPageWikiLink Bioavailability.
- Methylselenocysteine wikiPageWikiLink Brassica.
- Methylselenocysteine wikiPageWikiLink Caspase_3.
- Methylselenocysteine wikiPageWikiLink Category:Amino_acid_derivatives.
- Methylselenocysteine wikiPageWikiLink Category:Organoselenium_compounds.
- Methylselenocysteine wikiPageWikiLink Cell_cycle.
- Methylselenocysteine wikiPageWikiLink Chemoprophylaxis.
- Methylselenocysteine wikiPageWikiLink Fabaceae.
- Methylselenocysteine wikiPageWikiLink Hydrogen_selenide.
- Methylselenocysteine wikiPageWikiLink Methylcysteine.
- Methylselenocysteine wikiPageWikiLink Necrosis.
- Methylselenocysteine wikiPageWikiLink Scientific_Committee_on_Food.
- Methylselenocysteine wikiPageWikiLink Selenium_yeast.
- Methylselenocysteine wikiPageWikiLink Selenol.
- Methylselenocysteine wikiPageWikiLink Sodium_selenite.
- Methylselenocysteine wikiPageWikiLink Structural_analog.
- Methylselenocysteine wikiPageWikiLinkText "L-selenium-methylselenocysteine".
- Methylselenocysteine wikiPageWikiLinkText "Methylselenocysteine".
- Methylselenocysteine wikiPageWikiLinkText "methylselenocysteine".
- Methylselenocysteine imagefile "Methylselenocysteine.svg".
- Methylselenocysteine othernames "Se-methylseleno-(L)-cysteine; (L)-Methylselenocysteine; Se-Methylselenocysteine".
- Methylselenocysteine systematicname "3".
- Methylselenocysteine wikiPageUsesTemplate Template:Chembox.
- Methylselenocysteine wikiPageUsesTemplate Template:Chembox_Hazards.
- Methylselenocysteine wikiPageUsesTemplate Template:Chembox_Identifiers.
- Methylselenocysteine wikiPageUsesTemplate Template:Chembox_Properties.
- Methylselenocysteine wikiPageUsesTemplate Template:Reflist.
- Methylselenocysteine subject Category:Amino_acid_derivatives.
- Methylselenocysteine subject Category:Organoselenium_compounds.
- Methylselenocysteine hypernym Analog.
- Methylselenocysteine type ChemicalCompound.
- Methylselenocysteine type ChemicalSubstance.
- Methylselenocysteine type Drug.
- Methylselenocysteine type ChemicalObject.
- Methylselenocysteine type Thing.
- Methylselenocysteine type Q11173.
- Methylselenocysteine comment "Methylselenocysteine, also known as Se-methylselenocysteine, is an analog of S-methylcysteine in which the sulfur atom is replaced with a selenium atom. It is an inhibitor of DMBA-induced mammary tumorsand a \"chemopreventive agent that blocks cell cycle progression and proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture.\"Apoptosis has been proposed as the most plausible mechanism for the chemopreventive activities of selenocompounds.".
- Methylselenocysteine label "Methylselenocysteine".
- Methylselenocysteine sameAs Q21099600.
- Methylselenocysteine sameAs m.0135w6t2.
- Methylselenocysteine sameAs Q21099600.
- Methylselenocysteine wasDerivedFrom Methylselenocysteine?oldid=704264785.
- Methylselenocysteine depiction Methylselenocysteine.svg.
- Methylselenocysteine isPrimaryTopicOf Methylselenocysteine.