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- Medarex abstract "Medarex (former NASDAQ symbol: MEDX ) was an American biopharmaceutical company based in Princeton, New Jersey, with manufacturing facilities in Bloomsbury and Annandale, New Jersey, and research facilities in Milpitas and Sunnyvale, California. In 2009, Medarex was purchased by Bristol Myers Squibb.Medarex developed monoclonal antibodies to CTLA-4 and PD-1, which are proteins on the surface of T cells. T cells attack cancer cells, but CTLA-4 and PD-1 act as \"brakes\" on the T cell's anti-cancer activities. The monoclonal antibodies bind to these proteins and block them, releasing the T cell to attack cancer cells.Several monoclonal antibodies developed by Medarex have been approved for disease therapy. In 2009, the U.S. Food and Drug Administration approved Simponi, a human monoclonal antibody to tumor necrosis factor alpha co-developed with Johnson & Johnson's Janssen Biotech, for treatment of arthritis. In 2011, the U.S. FDA approved ipilimumab, a monoclonal antibody to CTLA-4, for treatment of metastatic melanoma.In 2014, the U.S. FDA approved nivolumab, a monoclonal antibody to PD-1, for treatment of advanced melanoma. Its use was expanded to the treatment of squamous non-small-cell lung carcinoma in 2015.".
- Medarex wikiPageExternalLink www.medarex.com.
- Medarex wikiPageID "10806484".
- Medarex wikiPageLength "4173".
- Medarex wikiPageOutDegree "32".
- Medarex wikiPageRevisionID "692774984".
- Medarex wikiPageWikiLink Annandale,_New_Jersey.
- Medarex wikiPageWikiLink Biopharmaceutical.
- Medarex wikiPageWikiLink Bloomsbury,_New_Jersey.
- Medarex wikiPageWikiLink Bristol-Myers_Squibb.
- Medarex wikiPageWikiLink CTLA-4.
- Medarex wikiPageWikiLink California.
- Medarex wikiPageWikiLink Category:Biotechnology_companies.
- Medarex wikiPageWikiLink Category:Bristol-Myers_Squibb.
- Medarex wikiPageWikiLink Category:Companies_based_in_Princeton,_New_Jersey.
- Medarex wikiPageWikiLink Category:Companies_formerly_listed_on_NASDAQ.
- Medarex wikiPageWikiLink Category:Pharmaceutical_companies_based_in_New_Jersey.
- Medarex wikiPageWikiLink Dartmouth_College.
- Medarex wikiPageWikiLink Donald_L._Drakeman.
- Medarex wikiPageWikiLink Food_and_Drug_Administration.
- Medarex wikiPageWikiLink Geisel_School_of_Medicine.
- Medarex wikiPageWikiLink Genmab.
- Medarex wikiPageWikiLink Golimumab.
- Medarex wikiPageWikiLink Ipilimumab.
- Medarex wikiPageWikiLink Janssen_Biotech.
- Medarex wikiPageWikiLink Johnson_&_Johnson.
- Medarex wikiPageWikiLink Milpitas,_California.
- Medarex wikiPageWikiLink Monoclonal_antibody.
- Medarex wikiPageWikiLink New_Jersey.
- Medarex wikiPageWikiLink Nivolumab.
- Medarex wikiPageWikiLink Non-small-cell_lung_carcinoma.
- Medarex wikiPageWikiLink Princeton,_New_Jersey.
- Medarex wikiPageWikiLink Programmed_cell_death_protein_1.
- Medarex wikiPageWikiLink Squamous-cell_carcinoma.
- Medarex wikiPageWikiLink Sunnyvale,_California.
- Medarex wikiPageWikiLink T_cell.
- Medarex wikiPageWikiLink Tumor_necrosis_factor_alpha.
- Medarex wikiPageWikiLink United_States.
- Medarex wikiPageWikiLinkText "Medarex Inc.".
- Medarex wikiPageWikiLinkText "Medarex".
- Medarex wikiPageUsesTemplate Template:Biotech-stub.
- Medarex wikiPageUsesTemplate Template:Med-company-stub.
- Medarex wikiPageUsesTemplate Template:Reflist.
- Medarex subject Category:Biotechnology_companies.
- Medarex subject Category:Bristol-Myers_Squibb.
- Medarex subject Category:Companies_based_in_Princeton,_New_Jersey.
- Medarex subject Category:Companies_formerly_listed_on_NASDAQ.
- Medarex subject Category:Pharmaceutical_companies_based_in_New_Jersey.
- Medarex hypernym Company.
- Medarex type Company.
- Medarex type Company.
- Medarex type Organization.
- Medarex type Organization.
- Medarex comment "Medarex (former NASDAQ symbol: MEDX ) was an American biopharmaceutical company based in Princeton, New Jersey, with manufacturing facilities in Bloomsbury and Annandale, New Jersey, and research facilities in Milpitas and Sunnyvale, California. In 2009, Medarex was purchased by Bristol Myers Squibb.Medarex developed monoclonal antibodies to CTLA-4 and PD-1, which are proteins on the surface of T cells.".
- Medarex label "Medarex".
- Medarex sameAs Q6805152.
- Medarex sameAs m.02qqlc_.
- Medarex sameAs Q6805152.
- Medarex wasDerivedFrom Medarex?oldid=692774984.
- Medarex isPrimaryTopicOf Medarex.