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- Mark_Purdey abstract "John Mark Purdey (25 December 1953 – 12 November 2006) was an English organic farmer who came to public attention in the 1980s, when he began to circulate his own theories regarding the causes of bovine spongiform encephalopathy (BSE or \"mad cow disease\").Purdey's interest in the disease was triggered when four cows he purchased for his farm developed the disease, though no animal raised on his farm ever contracted it. He also became aware of a fact also considerd by the Philips Inquiry: \"1145. The practice in the UK of recycling animal protein as an ingredient of animal feed dates back to at least 1926. In the 1970s attention was directed within MAFF to the danger that this practice would result in the spread of infectious diseases. The diseases considered were those caused by conventional viral and bacterial organisms. No consideration appears to have been given to the risk that scrapie might be recycled in sheep, or even transmitted to other farm animals. This may seem surprising. The answer probably lies in the fact that half a century had elapsed without any indication that animal feed containing ovine protein was infecting sheep or any other animal.\" Purdey published a number of papers in which he set down his belief that BSE was a transmissible disease that had an environmental cause. He suggested this cause might be Phosmet, a systemic organophosphate insecticide that was being spread along the spines of intensively farmed cows to eradicate warble fly. Purdey believed that the chemicals, derived from military nerve gases, disturbed the balance of metals in the animals' brains, namely reducing copper and increasing manganese, giving rise to the misfolded proteins called prions that are regarded as the cause of BSE. Through the High Court, he successfully challenged the British government's compulsory warble fly eradication program, which would have compelled him to treat his own cattle with the insecticide.The Phillips Inquiry rejected the original organophosphate hypothesis because the BSE epidemic continued even after phosmet use had become minimal yet most importantly because the original theory did not comport with the differences in BSE incidence between Guernsey and Jersey (opposite from what the original theory predicted).In his later papers on BSE, Purdey suggested in his modified hypothesis that a combination of high manganese and low copper in the soil, together with high environmental oxidising agents, might \"initiate a self-perpetuating free radical mediated neurodegenerative disease process (e.g., a TSE) in susceptible genotypes.\" He later speculated that Parkinson's and Alzheimer's may have similar biochemical triggers and pathways as transmissible spongiform encephalopathies (TSEs or prion diseases). His work was published in a number of minor peer-reviewed journals. He delivered lectures around the world to farmers and academics, and was invited to present his research to the British government's Phillips Inquiry into BSE. Purdey called himself an \"underground scientist\" and \"eco detective.\" He received a number of awards from New Age and organic farming organisations.Nonetheless, Purdey's views have not been accepted by mainstream scientists, mainly because official UK response to the epidemic conflates transmissibility with susceptibility. Yet the Phillips Inquiry has been reported as concluding that \"[t]he theory that BSE is caused by the application to cattle of organophosphorus pesticides is not viable, although there is a possibility that these can increase the susceptibility of cattle to BSE.\" Australian and CDC reports differed in material aspects from the Phillips Inquiry by differentiating causation and susceptibility. An noncritiqued unpublished report stated broadly that Purday's modified hypothesis did not fit the spatial distribution of reported incidences, but did not have the precision to decisively confirm or deny the modified hypothesis. Purday's scientific inquiries were based on his field work at outbreak hot spots worldwide and analysis of documentary evidence, thus his papers are mainly theoretical and contain no original biochemical clinical research. His modified theory awaits the results of future scientific inquiry.One aspect of ongoing research has been an examination of the flawed official scientific reasoning during the UK BSE crisis. There is also bias in comprehending, interpreting and reporting the conclusions of Purday, other scientists, and even the Phillips Inquiry (which actually stated: \"1123. The theory that BSE was caused by a reaction to the use of organophosphorus compounds (OPs) poured on cattle as systemic pesticides cannot be reconciled with the epidemiology and is not supported by research. One experiment has, however, given some limited support to the possibility that the OP phosmet might modify the susceptibility of cells to the prion disease agent.\").".
- Mark_Purdey birthDate "1953-12-25".
- Mark_Purdey birthYear "1953".
- Mark_Purdey deathDate "2006-11-12".
- Mark_Purdey deathYear "2006".
- Mark_Purdey wikiPageExternalLink 72866.stm.
- Mark_Purdey wikiPageExternalLink article1990371.ece.
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- Mark_Purdey wikiPageWikiLink Alzheimers_disease.
- Mark_Purdey wikiPageWikiLink Bovine_spongiform_encephalopathy.
- Mark_Purdey wikiPageWikiLink Category:1953_births.
- Mark_Purdey wikiPageWikiLink Category:2006_deaths.
- Mark_Purdey wikiPageWikiLink Category:British_activists.
- Mark_Purdey wikiPageWikiLink Category:British_farmers.
- Mark_Purdey wikiPageWikiLink Category:Cancer_deaths_in_England.
- Mark_Purdey wikiPageWikiLink Category:Deaths_from_brain_tumor.
- Mark_Purdey wikiPageWikiLink Category:People_educated_at_Haileybury_and_Imperial_Service_College.
- Mark_Purdey wikiPageWikiLink Category:People_from_Much_Hadham.
- Mark_Purdey wikiPageWikiLink Category:People_from_West_Somerset_(district).
- Mark_Purdey wikiPageWikiLink Creutzfeldt–Jakob_disease.
- Mark_Purdey wikiPageWikiLink Haileybury_and_Imperial_Service_College.
- Mark_Purdey wikiPageWikiLink Herbert_Kitchener.
- Mark_Purdey wikiPageWikiLink Intensive_animal_farming.
- Mark_Purdey wikiPageWikiLink Manganese.
- Mark_Purdey wikiPageWikiLink Much_Hadham.
- Mark_Purdey wikiPageWikiLink Organophosphate.
- Mark_Purdey wikiPageWikiLink Parkinsons_disease.
- Mark_Purdey wikiPageWikiLink Phosmet.
- Mark_Purdey wikiPageWikiLink Prince_of_Wales.
- Mark_Purdey wikiPageWikiLink Prion.
- Mark_Purdey wikiPageWikiLink Shell_shock.
- Mark_Purdey wikiPageWikiLink Ted_Hughes.
- Mark_Purdey wikiPageWikiLink Teresa_Gorman.
- Mark_Purdey wikiPageWikiLink The_Ecologist.
- Mark_Purdey wikiPageWikiLink Tom_King,_Baron_King_of_Bridgwater.
- Mark_Purdey wikiPageWikiLink Transmissible_spongiform_encephalopathy.
- Mark_Purdey wikiPageWikiLink Warble_fly.
- Mark_Purdey wikiPageWikiLink West_Somerset.
- Mark_Purdey wikiPageWikiLinkText "Mark Purdey".
- Mark_Purdey dateOfBirth "1953-12-25".
- Mark_Purdey dateOfDeath "2006-11-12".
- Mark_Purdey name "Purdey, Mark".
- Mark_Purdey shortDescription "BRitish activist".
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- Mark_Purdey description "BRitish activist".
- Mark_Purdey description "BRitish activist".
- Mark_Purdey subject Category:1953_births.
- Mark_Purdey subject Category:2006_deaths.
- Mark_Purdey subject Category:British_activists.
- Mark_Purdey subject Category:British_farmers.
- Mark_Purdey subject Category:Cancer_deaths_in_England.
- Mark_Purdey subject Category:Deaths_from_brain_tumor.
- Mark_Purdey subject Category:People_educated_at_Haileybury_and_Imperial_Service_College.
- Mark_Purdey subject Category:People_from_Much_Hadham.
- Mark_Purdey subject Category:People_from_West_Somerset_(district).
- Mark_Purdey hypernym Farmer.
- Mark_Purdey type Agent.
- Mark_Purdey type Person.
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- Mark_Purdey type Activist.
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- Mark_Purdey comment "John Mark Purdey (25 December 1953 – 12 November 2006) was an English organic farmer who came to public attention in the 1980s, when he began to circulate his own theories regarding the causes of bovine spongiform encephalopathy (BSE or \"mad cow disease\").Purdey's interest in the disease was triggered when four cows he purchased for his farm developed the disease, though no animal raised on his farm ever contracted it. He also became aware of a fact also considerd by the Philips Inquiry: \"1145.".
- Mark_Purdey label "Mark Purdey".
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- Mark_Purdey givenName "Mark".
- Mark_Purdey isPrimaryTopicOf Mark_Purdey.
- Mark_Purdey name "Mark Purdey".
- Mark_Purdey name "Purdey, Mark".
- Mark_Purdey surname "Purdey".