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- Macro_domain abstract "In molecular biology, the Macro domain or A1pp domain is a module of about 180 amino acids which can bind ADP-ribose, an NAD metabolite, or related ligands. Binding to ADP-ribose can be either covalent or non-covalent: in certain cases it is believed to bind non-covalently, while in other cases (such as Aprataxin) it appears to bind both non-covalently through a zinc finger motif, and covalently through a separate region of the protein.The domain was described originally in association with the ADP-ribose 1-phosphate (Appr-1-P)-processing activity (A1pp) of the yeast YBR022W protein and called A1pp. However, the domain has been renamed Macro as it is the C-terminal domain of mammalian core histone macro-H2A. Macro domain proteins can be found in eukaryotes, in (mostly pathogenic) bacteria, in archaea and in ssRNA viruses, such as coronaviruses, Rubella and Hepatitis E viruses. In vertebrates the domain occurs in e.g. histone macroH2A, predicted poly-ADP-ribose polymerases (PARPs) and B aggressive lymphoma (BAL) protein.ADP-ribosylation of proteins is an important post-translational modification that occurs in a variety of biological processes, including DNA repair, regulation of transcription, chromatin biology, maintenance of genomic stability, telomere dynamics, cell differentiation and proliferation, necrosis and apoptosis, and long-term memory formation. The Macro domain recognises the ADP-ribose nucleotide and in some cases poly-ADP-ribose, and is thus a high-affinity ADP-ribose-binding module found in a number of otherwise unrelated proteins. The Macro domain from human, macroH2A1.1, binds an NAD metabolite O-acetyl-ADP-ribose.The 3D structure of the Macro domain describes a mixed alpha/beta fold of a mixed beta sheet sandwiched between four helices with the ligand-binding pocket lies within the fold. Several Macro domain-only domains are shorter than the structure of AF1521 and lack either the first strand or the C-terminal helix 5. Well conserved residues form a hydrophobic cleft and cluster around the AF1521-ADP-ribose binding site.".
- Macro_domain symbol "Macro".
- Macro_domain thumbnail PDB_1zr3_EBI.jpg?width=300.
- Macro_domain wikiPageID "32114911".
- Macro_domain wikiPageLength "8100".
- Macro_domain wikiPageOutDegree "49".
- Macro_domain wikiPageRevisionID "619650892".
- Macro_domain wikiPageWikiLink ADP-ribosylation.
- Macro_domain wikiPageWikiLink Adenosine_diphosphate_ribose.
- Macro_domain wikiPageWikiLink Alpha_helix.
- Macro_domain wikiPageWikiLink Amino_acid.
- Macro_domain wikiPageWikiLink Apoptosis.
- Macro_domain wikiPageWikiLink Aprataxin.
- Macro_domain wikiPageWikiLink Archaea.
- Macro_domain wikiPageWikiLink B-cell_lymphoma.
- Macro_domain wikiPageWikiLink Beta_sheet.
- Macro_domain wikiPageWikiLink Binding_site.
- Macro_domain wikiPageWikiLink Biomolecular_structure.
- Macro_domain wikiPageWikiLink Category:Protein_domains.
- Macro_domain wikiPageWikiLink Cellular_differentiation.
- Macro_domain wikiPageWikiLink Chromatin.
- Macro_domain wikiPageWikiLink Cis-Regulatory_element.
- Macro_domain wikiPageWikiLink Conserved_sequence.
- Macro_domain wikiPageWikiLink Coronavirus.
- Macro_domain wikiPageWikiLink Covalent_bond.
- Macro_domain wikiPageWikiLink DNA_repair.
- Macro_domain wikiPageWikiLink Eukaryote.
- Macro_domain wikiPageWikiLink Genome.
- Macro_domain wikiPageWikiLink H2AFY.
- Macro_domain wikiPageWikiLink Helix.
- Macro_domain wikiPageWikiLink Hepatitis_E_virus.
- Macro_domain wikiPageWikiLink Homo_sapiens.
- Macro_domain wikiPageWikiLink Hydrophobe.
- Macro_domain wikiPageWikiLink Ligand.
- Macro_domain wikiPageWikiLink Mammal.
- Macro_domain wikiPageWikiLink Metabolite.
- Macro_domain wikiPageWikiLink Molecular_binding.
- Macro_domain wikiPageWikiLink Necrosis.
- Macro_domain wikiPageWikiLink Nicotinamide_adenine_dinucleotide.
- Macro_domain wikiPageWikiLink Non-covalent_interactions.
- Macro_domain wikiPageWikiLink Pathogenic_bacteria.
- Macro_domain wikiPageWikiLink Poly_ADP_ribose_polymerase.
- Macro_domain wikiPageWikiLink Post-translational_modification.
- Macro_domain wikiPageWikiLink Protein.
- Macro_domain wikiPageWikiLink Protein_domain.
- Macro_domain wikiPageWikiLink Protein_folding.
- Macro_domain wikiPageWikiLink RNA.
- Macro_domain wikiPageWikiLink Residue_(chemistry).
- Macro_domain wikiPageWikiLink Rubella_virus.
- Macro_domain wikiPageWikiLink Saccharomyces_cerevisiae.
- Macro_domain wikiPageWikiLink Telomere.
- Macro_domain wikiPageWikiLink Transcriptional_regulation.
- Macro_domain wikiPageWikiLink Vertebrate.
- Macro_domain wikiPageWikiLink Zinc_finger.
- Macro_domain caption "Crystal structure of the macro-domain of human core histone variant macroh2a1.1".
- Macro_domain cdd "cd02749".
- Macro_domain interpro "IPR002589".
- Macro_domain name "Macro".
- Macro_domain pfam "PF01661".
- Macro_domain pfamClan "CL0223".
- Macro_domain scop "1".
- Macro_domain symbol "Macro".
- Macro_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- Macro_domain wikiPageUsesTemplate Template:InterPro_content.
- Macro_domain wikiPageUsesTemplate Template:Orphan.
- Macro_domain wikiPageUsesTemplate Template:Reflist.
- Macro_domain subject Category:Protein_domains.
- Macro_domain hypernym Module.
- Macro_domain type Biomolecule.
- Macro_domain type Protein.
- Macro_domain type Software.
- Macro_domain type Chemical.
- Macro_domain type Domain.
- Macro_domain type Thing.
- Macro_domain type Q206229.
- Macro_domain type Q8054.
- Macro_domain comment "In molecular biology, the Macro domain or A1pp domain is a module of about 180 amino acids which can bind ADP-ribose, an NAD metabolite, or related ligands.".
- Macro_domain label "Macro domain".
- Macro_domain sameAs Q6725141.
- Macro_domain sameAs m.0gx2qsr.
- Macro_domain sameAs Q6725141.
- Macro_domain wasDerivedFrom Macro_domain?oldid=619650892.
- Macro_domain depiction PDB_1zr3_EBI.jpg.
- Macro_domain isPrimaryTopicOf Macro_domain.