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- MSH3 abstract "DNA mismatch repair protein, MutS Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. MSH3 typically forms the heterodimer MutSβ with MSH2 in order to correct long insertion/deletion loops and base-base mispairs in microsatellites during DNA synthesis. Deficient capacity for MMR is found in approximately 15% of colorectal cancers, and somatic mutations in the MSH3 gene can be found in nearly 50% of MMR-deficient colorectal cancers.".
- MSH3 entrezgene "4437".
- MSH3 wikiPageExternalLink mb1180711009.jpg.
- MSH3 wikiPageExternalLink nihms331260f3.jpg.
- MSH3 wikiPageID "14762085".
- MSH3 wikiPageLength "17731".
- MSH3 wikiPageOutDegree "21".
- MSH3 wikiPageRevisionID "678955872".
- MSH3 wikiPageWikiLink Acute_lymphoblastic_leukemia.
- MSH3 wikiPageWikiLink Adenine.
- MSH3 wikiPageWikiLink BRCA1.
- MSH3 wikiPageWikiLink C-terminus.
- MSH3 wikiPageWikiLink Carcinogen.
- MSH3 wikiPageWikiLink Colorectal_cancer.
- MSH3 wikiPageWikiLink DNA_mismatch_repair.
- MSH3 wikiPageWikiLink Dihydrofolate_reductase.
- MSH3 wikiPageWikiLink Gene_knockdown.
- MSH3 wikiPageWikiLink HL60.
- MSH3 wikiPageWikiLink HeLa.
- MSH3 wikiPageWikiLink K562_cells.
- MSH3 wikiPageWikiLink MSH2.
- MSH3 wikiPageWikiLink MSH6.
- MSH3 wikiPageWikiLink Methotrexate.
- MSH3 wikiPageWikiLink Microsatellite.
- MSH3 wikiPageWikiLink MutS-1.
- MSH3 wikiPageWikiLink Proliferating_cell_nuclear_antigen.
- MSH3 wikiPageWikiLink Protein_dimer.
- MSH3 wikiPageWikiLink Tumor_suppressor_gene.
- MSH3 wikiPageWikiLinkText "MSH3".
- MSH3 float "left".
- MSH3 image "IDL recognition by MutSβ. A close-up comparison of MSH3—IDL interaction and Taq MutS with a single unpaired base . DNA-binding domains and DNA in Loop4. Domains I and IV of MSH2 are shown in green and yellow, and MBD and clamp domains of MSH3 in blue and orange. Diagram of the protein-DNA interactions using the same color scheme as in . Space-filling model of four IDLs and their interaction with domain I of MSH2 and MBD of MSH3 . The base pairs surrounding the IDL are shown in light and dark pink. For Loop2 and Loop4, a back view looking into the minor groove is also shown.".
- MSH3 image "MutSβ Binding sites for MSH3 and MSH2 Model of the hMSH2 consensus interaction with hMSH3 or hMSH6. The interaction regions of hMSH2 with hMSH3 and of hMSH2 with hMSH6 are shown in gray and they are connected with lines that illustrate the specificity of each region to their pairing partner. The nucleotide binding regions are shown as black boxes. The location of the HNPCC mutations tested in these studies are illustrated as black diamonds. The N-terminal region of MSH3 contact the N-terminal region of MSH2 aa 378-625. The C-terminal regions connect at aa 1050-1128 of MSH3 and aa 875-934 of MSH2. Interestingly enough, the binding regions on MSH2 are identical when binding to either MSH3 or MSH6.".
- MSH3 requireManualInspection "no".
- MSH3 updateCitations "yes".
- MSH3 updatePage "yes".
- MSH3 updateProteinBox "yes".
- MSH3 updateSummary "yes".
- MSH3 width "258".
- MSH3 width "300".
- MSH3 wikiPageUsesTemplate Template:Cite_journal.
- MSH3 wikiPageUsesTemplate Template:External_media.
- MSH3 wikiPageUsesTemplate Template:PBB.
- MSH3 wikiPageUsesTemplate Template:PBB_Controls.
- MSH3 wikiPageUsesTemplate Template:PBB_Further_reading.
- MSH3 wikiPageUsesTemplate Template:Refbegin.
- MSH3 wikiPageUsesTemplate Template:Refend.
- MSH3 wikiPageUsesTemplate Template:Reflist.
- MSH3 hypernym Homologue.
- MSH3 type Biomolecule.
- MSH3 type Drug.
- MSH3 type Protein.
- MSH3 type Thing.
- MSH3 type Q206229.
- MSH3 type Q8054.
- MSH3 comment "DNA mismatch repair protein, MutS Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. MSH3 typically forms the heterodimer MutSβ with MSH2 in order to correct long insertion/deletion loops and base-base mispairs in microsatellites during DNA synthesis.".
- MSH3 label "MSH3".
- MSH3 sameAs Q18029418.
- MSH3 sameAs m.03gx2yb.
- MSH3 sameAs Q18029418.
- MSH3 wasDerivedFrom MSH3?oldid=678955872.
- MSH3 isPrimaryTopicOf MSH3.
