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- MEG3 abstract "MEG3 (maternally expressed 3) is a maternally expressed, imprinted long non-coding RNA gene. At least 12 different isoforms of MEG3 are generated by alternative splicing. Expression of MEG3 is lost in cancer cells. It acts as a growth suppressor in tumour cells, and activates p53. A pituitary transcript variant has been associated with inhibited cell proliferation. Studies in mouse and sheep suggest that an upstream intergenic differentially methylated region (IG-DMR) regulates imprinting of the region. The expression profile in mouse of the co-regulated Meg3 and Dlk1 genes suggests a causative role in the pathologies found in uniparental disomy animals, characterized by defects in skeletal muscle maturation, bone formation, placenta size and organization and prenatal lethality. The sheep homolog is associated with the callipyge mutation which in heterozygous individuals affects a muscle-specific long-range control element located in the DLK1-GTL2 intergenic region and results in the callipyge muscular hypertrophy. The non-Mendelian inheritance pattern, known as polar overdominance, likely results from the combination of the cis-effect on the expression levels of genes in the DLK1-GTL2 imprinted domain, and trans interaction between the products of reciprocally imprinted genes.".
- MEG3 entrezgene "55384".
- MEG3 wikiPageID "16853098".
- MEG3 wikiPageLength "5428".
- MEG3 wikiPageOutDegree "29".
- MEG3 wikiPageRevisionID "678954057".
- MEG3 wikiPageWikiLink Alternative_splicing.
- MEG3 wikiPageWikiLink Bone.
- MEG3 wikiPageWikiLink Category:Non-coding_RNA.
- MEG3 wikiPageWikiLink Cell_growth.
- MEG3 wikiPageWikiLink Cis-Regulatory_element.
- MEG3 wikiPageWikiLink DLK1.
- MEG3 wikiPageWikiLink Gene.
- MEG3 wikiPageWikiLink Genomic_imprinting.
- MEG3 wikiPageWikiLink Glossary_of_sheep_husbandry.
- MEG3 wikiPageWikiLink Homology_(biology).
- MEG3 wikiPageWikiLink Hypertrophy.
- MEG3 wikiPageWikiLink IG-DMR.
- MEG3 wikiPageWikiLink Intergenic_region.
- MEG3 wikiPageWikiLink Long_non-coding_RNA.
- MEG3 wikiPageWikiLink Mendelian_inheritance.
- MEG3 wikiPageWikiLink Methylation.
- MEG3 wikiPageWikiLink Mouse.
- MEG3 wikiPageWikiLink Neoplasm.
- MEG3 wikiPageWikiLink P53.
- MEG3 wikiPageWikiLink Pituitary_gland.
- MEG3 wikiPageWikiLink Placenta.
- MEG3 wikiPageWikiLink Polar_overdominance.
- MEG3 wikiPageWikiLink Prenatal_development.
- MEG3 wikiPageWikiLink Sheep.
- MEG3 wikiPageWikiLink Skeletal_muscle.
- MEG3 wikiPageWikiLink Trans-acting.
- MEG3 wikiPageWikiLink Uniparental_disomy.
- MEG3 wikiPageWikiLink Zygosity.
- MEG3 wikiPageWikiLinkText "Callipyge".
- MEG3 wikiPageWikiLinkText "MEG3".
- MEG3 wikiPageWikiLinkText "callipyge".
- MEG3 requireManualInspection "no".
- MEG3 updateCitations "yes".
- MEG3 updatePage "yes".
- MEG3 updateProteinBox "yes".
- MEG3 updateSummary "yes".
- MEG3 wikiPageUsesTemplate Template:Cite_journal.
- MEG3 wikiPageUsesTemplate Template:Molecular-cell-biology-stub.
- MEG3 wikiPageUsesTemplate Template:PBB.
- MEG3 wikiPageUsesTemplate Template:PBB_Controls.
- MEG3 wikiPageUsesTemplate Template:PBB_Further_reading.
- MEG3 wikiPageUsesTemplate Template:Refbegin.
- MEG3 wikiPageUsesTemplate Template:Refend.
- MEG3 wikiPageUsesTemplate Template:Reflist.
- MEG3 subject Category:Non-coding_RNA.
- MEG3 type Biomolecule.
- MEG3 type Protein.
- MEG3 type Thing.
- MEG3 type Q206229.
- MEG3 type Q8054.
- MEG3 comment "MEG3 (maternally expressed 3) is a maternally expressed, imprinted long non-coding RNA gene. At least 12 different isoforms of MEG3 are generated by alternative splicing. Expression of MEG3 is lost in cancer cells. It acts as a growth suppressor in tumour cells, and activates p53. A pituitary transcript variant has been associated with inhibited cell proliferation.".
- MEG3 label "MEG3".
- MEG3 sameAs Q18041809.
- MEG3 sameAs m.0408fdp.
- MEG3 sameAs Q18041809.
- MEG3 wasDerivedFrom MEG3?oldid=678954057.
- MEG3 isPrimaryTopicOf MEG3.